Dynamics of neutralizing antibody responses to SARS-CoV-2 in patients with COVID-19: an observational studyCOVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 반응의 역학: 관찰 연구Clinical Trial Published on 2021-05-182022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 진단, 치료기술, [키워드] age albumin antibody-based therapy caution China Cohort correlated COVID-19 COVID-19 patient decay declined Dilution disease severity Dynamics enrolled feasibility FRNT half-time infected individual Infection Infectious diseases median time Mild NAb NAbs neutralization neutralization test Neutralizing activity neutralizing antibody Neutralizing antibody response observation onset of symptoms Patient peaked positive positively correlated protective immunity reached remained SARS-CoV-2 Seroconversion serum albumin severity of COVID-19 surrogate virus neutralization test sVNT Vaccine validation study virus neutralization test [DOI] 10.1038/s41392-021-00611-6 PMC 바로가기 [Article Type] Clinical Trial
Multi-modality detection of SARS-CoV-2 in faecal donor samples for transplantation and in asymptomatic emergency surgical admissions이식 및 무증상 응급 수술 입원을 위한 대변 기증자 샘플에서 SARS-CoV-2의 다중 양식 검출Brief Report Published on 2021-05-112022-09-11 Journal: F1000Research [Category] MERS, SARS, 치료기술, [키워드] Admission Asymptomatic asymptomatic patient asymptomatic patients average carried clearance Clostridioide Clostridioides Critical care demonstrated detectable detection digital PCR Dilution dilution series dilution sery Donor donor sample extracted RNA Faecal microbiota transplant infected with SARS-CoV-2 Inpatient LAMP less linear lowest microbiota Pathways qPCR Quantitative respiratory RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral shown Stool surgical symptomatic symptomatic patient Symptomatic patients tested Treatment upper respiratory tract Viral virus [DOI] 10.12688/f1000research.52178.1 PMC 바로가기 [Article Type] Brief Report
The Stability of Model Human Coronaviruses on Textiles in the Environment and during Health Care Laundering환경 및 의료 세탁 중 직물에 대한 모델 인간 코로나바이러스의 안정성Research Article Published on 2021-04-282022-09-10 Journal: mSphere [Category] MERS, SARS, 치료기술, [키워드] (artificial saliva) able to transfer acting acute respiratory syndrome acute respiratory syndrome coronavirus Agitation artificial saliva Care conditions coronavirus coronavirus disease Coronavirus disease 2019 cotton COVID-19 Culture decontamination demonstrated detectable detergent determine Dilution Efficacy Environment Evidence fiber handling HCoV HCoV-229E HCoV-OC43 Health Health care Human human coronavirus human coronavirus OC43 human coronaviruses Incubation infection control Infective dose Infectivity laundering laundry log Low temperatures Model OC43 persist persistence plastic polyester provide reduction required Research respiratory risk Saliva SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread stability stainless steel synthetic TCID TCID50 temperature textile textiles tissue tissue culture transfer transferred Transmission United Kingdom United States virus [DOI] 10.1128/mSphere.00316-21 PMC 바로가기 [Article Type] Research Article
Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR testsReport Published on 2021-04-142022-10-29 Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Analysis applied approach collected coronavirus Dilution distribution Efficacy Efficiency eliminated exceeded False positives in vitro Infection infection rate lesson nasopharyngeal sample Patient polymerase chain pooling positive sample Prevalence question reaction reduce cost reduced reduction in resources reverse transcription RNA extraction RT-PCR RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR test SARS-CoV-2 testing sensitivity specificity sputum samples Support Surveillance Swab swab sample tested Viral load [DOI] 10.1126/scitranslmed.abf2823 PMC 바로가기 [Article Type] Report
Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 via Multi-Parameter Detection새로운 ELISA 프로토콜은 기존 SARS-CoV-2 반응성 항체를 풍토성 코로나바이러스 면역 및 연령과 연결하고 다중 매개변수 감지를 통해 급성 COVID-19의 향상된 혈청학적 식별을 나타냅니다.Immunology Published on 2021-04-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Abbott Abbott test acute COVID-19 added age antibodies antibody Antibody detection antibody levels approved assays binding domain buffer circulating coated coronavirus COVID-19 COVID-19 pandemic detection Dilution disease disease status Economy ELISA ELISA protocol Endemic EUA HIV Hospitalized identification IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgM Immunity immunoassay impacted implication Improved infected individuals information life magnitude measurement Microparticle novel nuance nuances nucleocapsid (N) nucleocapsid protein optical densities optical density platform pre-existing immunity RBD reactive reagents receptor binding domain (RBD) reported SARS-CoV-2 SARS-CoV-2 IgM SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitive serologic serology serology test significantly lower SLE specific IgM standard curve Strains subject subjects Symptoms utility Viral protein Viral proteins virus transmission [DOI] 10.3389/fimmu.2021.614676 PMC 바로가기 [Article Type] Immunology
Which factors influence the extent of indoor transmission of SARS-CoV-2? A rapid evidence reviewResearch Theme 6: UNCOVER - Usher Institute Network of COVID-19 Evidence Reviews Published on 2021-04-032022-10-31 Journal: Journal of Global Health [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval activities activity Analysis appraisal article articles conducted Contact coughing COVID-19 database decrease Dilution dispersal droplet droplet transmission epidemiological Epidemiological study Epidemiology evaluate Evidence example Factor Fluid mechanics household transmission identify Inconclusive Joanna Briggs Institute mechanism Meta-analysis pandemic physical potential risk provide reduce rejection Result retained risk risk factor Schools screened secondary attack rate skill synthesised Transmission transmission of SARS-CoV-2 unique Ventilation Viral RNA virus virus transmission WHO Workplace [DOI] 10.7189/jogh.11.10002 PMC 바로가기 [Article Type] Research Theme 6: UNCOVER - Usher Institute Network of COVID-19 Evidence Reviews
SARS-CoV-2 and indoor/outdoor air samples: a methodological approach to have consistent and comparable resultsSARS-CoV-2 및 실내/실외 공기 샘플: 일관되고 비교 가능한 결과를 얻기 위한 방법론적 접근Article Published on 2021-04-012022-09-11 Journal: Environmental research [Category] SARS, 치료기술, [키워드] aerosol Air quality filters Airborne transmission alteration approach bioaerosol comparable Complete Concentration Consistency coronavirus disease Coronavirus disease 2019 COVID-19 Degradation diffusion Dilution Effect Environmental virology Evidence evidence of freezing information inhibitors lack limits magnitude manipulation matter methodological overcome pandemic Quality assurance quantification robustness sampling SARS-CoV-2 single sampling Standardization the disease transmission of SARS-CoV-2 virus wastewater [DOI] 10.1016/j.envres.2021.110847 PMC 바로가기 [Article Type] Article
Adjusting the Cut-Off and Maximum Pool Size in RT-qPCR Pool Testing for SARS-CoV-2SARS-CoV-2에 대한 RT-qPCR 풀 테스트에서 컷오프 및 최대 풀 크기 조정Article Published on 2021-03-262022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] Adjusting Brazil Care caused Chain Reaction Consistency COVID-19 cut-off cut-off value cycle threshold dependent on detect detectability detectable Dilution edge Emergency Care ENhance evaluated flu-like symptoms Large-scale testing maximum methodology MONITOR occurrence of COVID-19 polymerase chain polymerase chain reaction pool pool testing pooling positive presenting Quantitative RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sensitivity Testing the edge trade-off Transcription [DOI] 10.3390/v13040557 PMC 바로가기 [Article Type] Article
Recovering coronavirus from large volumes of water대량의 물에서 코로나바이러스 복구Article Published on 2021-03-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] both virus both viruses centrifugation Concentration Contamination coronavirus coronavirus disease COVID-19 dead demonstrated diarrhea Dilution enveloped virus epidemic diarrhea fiber filtration inhibitor limitation mengovirus methodology Occurrence overcome pandemic PCR PEDV Quantitative question resource RNA RT-qPCR SARS-CoV-2 Seawater sensitivity significant difference statistical surface Surface water tap tap water Tap water. viral particle Viral particles virus Volume water water cycle Water resources [DOI] 10.1016/j.scitotenv.2020.143101 PMC 바로가기 [Article Type] Article
Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum인간 혈청에서 2차원 동위원소 희석 LC-MS/MS 방법을 통한 7가지 용도 변경 COVID-19 약물 렘데시비르(대사산물 GS-441524 포함), 클로로퀸, 히드록시클로로퀸, 로피나비르, 리토나비르, 파비피라비르 및 아지트로마이신의 동시 정량화Article Published on 2021-03-202022-09-11 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 신약개발, 치료제, [키워드] analogue analytical column antiviral therapy Azithromycin Bioanalytical Method Validation Chloroquine Concentration controls COVID-19 COVID-19 pandemic COVID-19 patient develop Dilution drug drug candidate drugs Efficacy and safety European Medicines Agency Favipiravir GS-441524 human serum Hydroxychloroquine inaccuracy injection Isotope Isotope dilution liquid chromatography tandem mass spectrometry (ID-LC–MS/MS) Liquid chromatography Lopinavir LOPINAVIR AND RITONAVIR mass spectrometry metabolite protein precipitation protocol provided quantification quantitative assay Remdesivir Ritonavir robust sensitivity separated serum Seven Simultaneous solid phase Tandem mass spectrometry therapeutic drug Therapeutic Drug Monitoring Treatment two-dimensional Volume were used [DOI] 10.1016/j.jpba.2021.113935 PMC 바로가기 [Article Type] Article