Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial간질 세포 투여에 의한 급성 호흡 곤란 증후군의 회복(REALIST): 공개 라벨 용량 증량 1상 시험에 이어 무작위, 삼중 맹검, 할당 은폐, 위약 대조 2상 시험을 위한 구조화된 연구 프로토콜Article Published on 2022-05-132022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress acute respiratory distress syndrome administration allocation ARDS benefit blind causes Cell cells clinical clinical trial Cohort cohort of patient cohorts of patients concealed CONSORT COVID-19 distress dose dose-escalation early stage early stages Efficacy EudraCT Good immunomodulatory incidence include Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells moderate to severe MSC MSCs multicentre NHS number Open-label outcome outlined oxygenation index patients patients with moderate Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled placebo-controlled trial Practice produced protocol randomised rationale receive recruited recruitment repair reported Reporting respiratory distress Respiratory distress syndrome Serious Adverse Events severe ARDS Standard stromal cell stromal cells Study protocol syndrome therapy Trial triple-blind umbilical Umbilical cord [DOI] 10.1186/s13063-022-06220-0 PMC 바로가기 [Article Type] Article
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease Research Published on 2022-05-112022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Affect age alteration Alzheimer’s disease animal model baseline Biomarker Brain buffer change characterized comparable comparison detect determine develop dimension disease dysfunction early stage Effect facilitated Factor Fractal Genotype histopathological increase in indicated injected injection Interaction lack linear longitudinal majority mice neurodegenerative outcomes pathological change Pathologies pathology performed plaque quantified reduction returned statistically the disease wild-type [DOI] 10.1038/s41598-022-11582-1 [Article Type] Research
New Psychoactive Substances and receding COVID-19 pandemic: really going back to “normal”?새로운 정신 활성 물질과 코로나19 대유행 퇴조: 정말 "정상"으로 돌아가는가?Article Published on 2022-05-112022-09-11 Journal: Acta bio-medica : Atenei Parmensis [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Abuse agency analogue Analysis appear approach arising available data benzimidazole can not Case report case reports Characteristics check circumvent clonitazene club compounds COVID-19 COVID-19 pandemic criminal criminality Dark Web death deaths derivative detectable detection system disorders diversion dosages drug Drug Abuse early stage early stages ecosystem Effect effective Effects effort Endemic etonitazene European Exacerbation fatality fentanyl FIVE form Health Service Health services healthcare implicated implication increasingly information Interaction involved isotonitazene less magnitude mechanism media metonitazene mistake Mortality New nine NMR NPs opioid opioids Opioids abuse overdose pandemic Probing public health public health emergency Public health responses receptor reduction Reduction potential replicate Research resource rising risk Scientific community seeking selected significantly more social media Still Stress substance substance abuse supply supply and demand Surveillance the SARS-CoV-2 traffickers turn urgency user experience variants web-based platform X-ray diffraction [DOI] 10.23750/abm.v93i2.13008 PMC 바로가기 [Article Type] Article
COVID-19 Literature Published in Emergency Medicine Journals in 2020Observational Study Published on 2022-05-052022-10-05 Journal: Western Journal of Emergency Medicine [Category] 임상, [키워드] Abstract adopted Analysis article average category citation contributed Coronavirus disease 2019 COVID-19 COVID-19 research database early stage Emergency indicated Infectious disease journal knowledge literature Medicine National Non-COVID-19 outcome pandemic proportion Research researcher response retrieved retrospective Transmission [DOI] 10.5811/westjem.2022.1.55029 PMC 바로가기 [Article Type] Observational Study
A novel epidemiological scoring system for the prediction of mortality in COVID-19 patientsCOVID-19 환자의 사망률 예측을 위한 새로운 역학 채점 시스템Article Published on 2022-05-022022-09-11 Journal: Transactions of the Royal Society of Tropical Medi [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Admission age AUROC breathlessness characteristic clinical symptom Clinical symptoms co-morbidities Cohort Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 patient COVID-19 patients COVID-19 scoring system CSS develop diabete diabetes diagnostic Diagnostic accuracy early prediction of mortality early stage epidemiological group higher risk hospital independent risk factor indicate inflammatory markers Mann Whitney U Test medium morbidities Mortality MOST patient age positive positive relationship predicted proportion receiver operating characteristic receiver operating characteristic curve reported risk Risk factors Scoring Scoring and validation cohort scoring system Sensitivity and specificity severe COVID-19 patients Treatment Triage validation cohort were used [DOI] 10.1093/trstmh/trab108 PMC 바로가기 [Article Type] Article
Can Serum Endocan Levels be Used as an Early Prognostic Marker for Endothelial Dysfunction in COVID-19?혈청 엔도칸 수치를 COVID-19의 내피 기능 장애에 대한 조기 예후 마커로 사용할 수 있습니까?Article Published on 2022-05-012022-09-11 Journal: Angiology [Category] MERS, 바이오마커, [키워드] age blood gas Can Correlation analysis COVID-19 COVID-19 prognosis diagnosis of COVID-19 early stage endocan Endothelial dysfunction female Follow-up group Hospitalized indicated Lactate Level male mortality rate onset of symptom Patient patients Pneumonia positive correlation Prognosis Prognostic marker SARS-CoV-2 serum severe pneumonia the disease Vascular damage venous blood venous blood gas was determined were measured [DOI] 10.1177/00033197211050446 PMC 바로가기 [Article Type] Article
Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations숙주 내 SARS-CoV-2 단일 뉴클레오타이드 변이체가 COVID-19 전염병의 초기 단계에서 출현하여 인구 고정 돌연변이가 예측됨Article Published on 2022-05-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), SARS, 변종, [키워드] Abstract COVID-19 COVID-19 pandemic early stage Fixed mutation Intra-host single-nucleotide variants Mutation SARS-CoV-2 single-nucleotide variant [DOI] 10.1016/j.jinf.2022.01.016 PMC 바로가기 [Article Type] Article
Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry JapanObservational Study Published on 2022-05-012022-10-04 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval Admission Clinical outcome COVID-19 COVID-19 cases early stage Effectiveness evaluate evaluated Evidence extracorporeal membrane oxygenation had no hazard ratio Hospitalization Hospitalized hospitalized patient in-hospital mortality inclusion criteria Invasive mechanical ventilation inverse Inverse probability treatment weighting Japan lower risk not significantly different outcome Oxygen requirement Patient patients with COVID-19 Placebo positive Primary outcome Probability Randomized controlled trial reduce reduction in regimen registry Remdesivir risk secondary supplementary oxygen therapy Treatment Weighting with COVID-19 [DOI] 10.1016/j.ijid.2022.02.039 PMC 바로가기 [Article Type] Observational Study
The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repressionNSP1 매개 억제의 바이러스 탈출에 필요한 SARS-CoV-2 리더 및 NSP1의 주요 기능Article Published on 2022-05-012022-09-11 Journal: RNA (New York, N.Y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis Antiviral ASO binding blockade carried cellular mechanisms cellular mRNA cellular mRNAs component components cytosine Defense down-regulate early stage ENhance expresse expression feature functional global pandemic help Host host gene host genes Infection inhibit interfere mechanism mRNA mRNAs nonstructural protein 1 nsp1 overcome Pathways Replication required residue responsible ribosome SARS-CoV-2 Spread targets the SARS-CoV-2 translation translational repression translational repression. viral escape viral mRNAs Viral RNA virus viruses [DOI] 10.1261/rna.079086.121 PMC 바로가기 [Article Type] Article
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemicResearch article Published on 2022-05-012022-10-05 Journal: Heart Rhythm [Category] 신약개발, [키워드] 24 hour African African American APD arrhythmia baseline cells condition conditions coronavirus disease COVID-19 COVID-19 pandemic death Drug-induced long QT syndrome early stage Effect had no HCQ Hydroxychloroquine increase in individual Induced pluripotent stem cell–derived cardiomyocyte Long QT syndrome male no difference objective p.Ser1103Tyr-SCN5A pandemic physiological polymorphism Result risk SCD SCN5A significant increase significantly significantly higher Stress Treatment variant was used [DOI] 10.1016/j.hrthm.2021.12.029 [Article Type] Research article