Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial신속한 모집 및 보급이 Covid-19 사망률에 미치는 영향: RECOVERY 시험Opinion Article Published on 2020-12-232022-09-11 Journal: F1000Research [Category] MERS, 임상, [키워드] adaptive Analysis COVID-19 decreased mortality demonstrated Dexamethasone dissemination Effect eligible patient Eligible patients hospitalised patient Hospitalised patients Hydroxychloroquine Mortality oxygen pandemic Patient randomised controlled trial RECOVERY trial recruited recruitment reduce reducing mortality significantly speed supplemental oxygen Treatment Trial ventilator [DOI] 10.12688/f1000research.25842.2 PMC 바로가기 [Article Type] Opinion Article
Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trialCOVID-19에 대한 Arbidol(Umifenovir)의 효과: 무작위 대조 시험Randomized Controlled Trial Published on 2020-12-142022-08-13 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료제, [키워드] (Lopinavir/ritonavir adjusted Admission age Analysis antiviral drugs ARB Arbidol ARMS assigned Chest CT Clinical improvement contribute Corona virus cough COVID-19 COVID-19 disease criteria determine diagnosis of COVID-19 duration of hospitalization Dyspnea Effect effective Efficacy eligible patient ESR examined Fever Final final analysis followed by group groups Health Organization hospital Hospitalization Hydroxychloroquine ICU admissions IHD Improvements independent Kaletra Laboratory less Lopinavir Lopinavir/ritonavir male multicenter design Multiple linear regression multiple linear regression analysis Na level Open-label open-label randomized controlled trial oxygen oxygen saturation Patient patients with COVID-19 peripheral peripheral oxygen saturation Peripheral oxygen saturation rate Primary outcome Randomized controlled trial Randomly recruited relief Result Ritonavir Sample size significance level significantly supportive care Symptom the disease therapy time treatments for COVID-19 Trial registration two group two groups variable WBC WHO World Health Organization [DOI] 10.1186/s12879-020-05698-w PMC 바로가기 [Article Type] Randomized Controlled Trial
CovEMERALD: Assessing the feasibility and preliminary effectiveness of remotely delivered Eye Movement Desensitisation and Reprocessing following Covid-19 related critical illness: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-172022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 24 hours activity monitor addition adverse event age ALEA anticipated Anxiety Appetite Assessing assigned blinded Care case report form clinical Cognitive impairment Cohort control arm Council COVID-19 Critical Data analysis Depression description determine Diagnosis discharge discharge home dissemination Effectiveness eight element eligible patient Emdr episode excluded expected exploratory expressed eye Eye-movement desensitisation and reprocessing feasibility Final Follow-up group Group allocation hospital hospital discharge IMPROVE incidence intensive care intensive care unit Intervention intervention arm intervention group measure mechanical ventilation Mortality movement number nutrition objective outcome participant Patient patient reported outcome physical physical activity polymerase chain positive Primary outcome protocol Psychological Psychology PTSD Quality of life randomised randomised controlled randomised controlled trial Randomly receive recent recruited recruitment Registered reported Sample size scale secondary service Standard standard care status Study protocol survivor Survivors Template tested Trial trial protocol United Kingdom university usual care Version website [DOI] 10.1186/s13063-020-04805-1 PMC 바로가기 [Article Type] Letter
A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-10-062022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 active cancer addition administration age ambient analysed anti-SARS-CoV-2 Antibody titer antibody titres anticipated ARMS assessment baseline Blinding Block randomisation breathing ambient air case report form changes in Chemotherapy clearance clinical clinical condition Clinical outcome collected Confirmed Contact convalescence convalescent plasma COVID-19 criteria cross cytokine profile D-dimer death defined described diagnostic discharge discharged patient dissemination Donor Duration early application eCRF Effect element eligibility eligible eligible patient Enrollment EudraCT exclusion criteria expected experimental arm exploratory feature Follow-up follow-up period group Hematological malignancy high risk high-risk patient high-risk patients with severe disease hospital Hospital admission Hospital stay Hospitalized Immunosuppression inclusion criteria Infection infusion investigator laboratory data Last less mechanical ventilation multicenter non-parametric test number objective Open-label outcome overall survival participant Patient performed plasma positive protocol quarter Radiotherapy randomisation randomised randomised controlled trial randomization system Randomized receive recruitment Registered report reported required Requirement risk routine care Sample size SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 viral schedule secondary Secondary objective Seven seven-point ordinal scale Standard Standard of care status Stratification Study protocol subject survival survival rate survival rates Swab table the patient therapy time Total treated Treatment Trial underlying disease Viral load website worsening [DOI] 10.1186/s13063-020-04735-y PMC 바로가기 [Article Type] Letter
A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial미분화 결합 조직 질환이 있는 여성의 반복적인 임신 상실을 치료하기 위한 하이드록시클로로퀸 및 저용량 프레드니손의 3군, 다기관, 공개 라벨 무작위 대조 시험: LIFE(LIFE) 시험을 위한 면역억제 요법에 대한 프로토콜Study Protocol Published on 2020-09-092022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] abortion Activation addition Anticoagulant anticoagulation Arm assigned connective tissue connective tissue disease Controlled trial defined disease Efficacy eligible patient evaluate Evidence HCQ Hydroxychloroquine immune Immunosuppressant include induce Inflammation live births low-dose morbidities multicenter Open-label open-label randomized controlled trial outcome Patient patients placental Prednisone Pregnancy Prevent Primary outcome Prognosis progression protocol Randomized controlled trial Randomly Recurrent pregnancy loss Recurrent spontaneous abortion regimen secondary Secondary outcomes spontaneous abortion treat Trial Trial registration Undifferentiated Undifferentiated connective tissue disease Vascular damage women [DOI] 10.1186/s13063-020-04716-1 PMC 바로가기 [Article Type] Study Protocol
Potential Role of Acacia Senegal (Gum Arabic) as Immunomodulatory Agent among newly diagnosed COVID 19 Patients: A structured summary of a protocol for a randomised, controlled, clinical trialLetter Published on 2020-09-052022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 Acacia addition agent Anti-inflammatory Arabic assigned assistant baseline baseline value blind change Clinical guidelines clinical trial computer-generated conducted Control COVID COVID 19 COVID 19 patient COVID-19 COVID-19 patients CRP Cytokines Date death diagnosed dissemination Efficacy element eligible patient Factor Gender group groups Gum Gum Arabic Hospital admission IL10 IL6 IL8 immunomodulation immunomodulatory independent Intervention Local mortality rate number objective outcome parallel-group participant Patient patients PCR Pectin phase Placebo placebo-controlled clinical trial Potential Prospective protocol provided random randomised randomised controlled trial randomization Randomized Randomly Real-time PCR receive Research response role Sample size secondary sequence seropositive Soba standard care state status TNFα Treatment Trial Tumor Two-arm university Version Viral load website [DOI] 10.1186/s13063-020-04707-2 PMC 바로가기 [Article Type] Letter
Multi-centre, three arm, randomized controlled trial on the use of methylprednisolone and unfractionated heparin in critically ill ventilated patients with pneumonia from SARS-CoV-2 infection: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-08-172022-10-29 Journal: Trials [Category] Coronavirus, MERS, [키워드] 24 hour absolute reduction Administered administration AIFA airway allocation sequence Alpha Anticoagulant anticoagulant therapy Anticoagulant treatment approval Arm Aspergillus assigned assumption average bleeding bleeding event blinded Block randomisation block size BMI Brain Breastfeeding Candida checked childbearing age chronic clinical clinical condition clinically combined use conjunctival contributed corpus Corticosteroid COVID-19 criteria Critical Critically ill cytomegalovirus D-dimer level death defined Delay detect diagnostic discharge dissemination dosage drug dysfunction effective element eligible patient enoxaparin enrolled EudraCT exclusion criteria expected hematemesis hematoma heparin-induced thrombocytopenia Herpe high risk High-dose history hospital hospital discharge Hypothesis ICU ICU free day ICU Patients impairing Inclusion inclusion criteria indicated Infection initial Inpatient intensive care unit interval Intervention Intra-articular intramuscular intravenously invasive Invasive mechanical ventilation investigator Italian limit LMWH low molecular weight low-molecular weight heparin macroscopic major bleeding mechanical ventilation medical intervention Methylprednisolone Mortality mortality rate Myocardial Non-invasive non-invasive ventilation number objective occur ophthalmic organ dysfunction PaO parallel group participant Patient performed Pharyngeal swab Pneumonia positive positive pressure pregnancy test Presence Prophylactic prophylactic dose Prophylaxis protocol random randomisation randomised randomised controlled trial randomization Randomized Randomized controlled trial Randomly Ratio receive recent recruited recruitment Rectal Bleeding red blood cell reduce reducing Registered required risk of death Safety Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia secondary secure severe disease sick significantly sodium status steroid stratified stroke study drug Study protocol subcutaneously surgical syndrome therapeutic therapeutic doses therapy Treatment treatment group unfractionated heparin Venous Thromboembolism ventilated patient Ventilation website Weighting Withdrawal women [DOI] 10.1186/s13063-020-04645-z PMC 바로가기 [Article Type] Letter
Nigella sativa supplementation to treat symptomatic mild COVID-19: A structured summary of a protocol for a randomised, controlled, clinical trialLetter Published on 2020-08-082022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 absence Admission Alanine transaminase assigned Black seed Blinding block Breast feeding Chronic kidney disease chronic liver disease clinical trial clinically comparator computer-generated randomization conducted control group control groups COVID-19 COVID19 Date defined dialysis disease dissemination Efficacy element eligible patient exploratory glomerular filtration rate hospital Infection intensive care Jeddah King limit medication Mild Nigella Sativa no symptoms number objective Open-label outcome parallel-group participant Patient phytotherapy Pneumonia polymerase chain reaction Prospective protocol radiological randomisation randomised randomised controlled trial Randomly recruited renal respiratory Sample size SARS-CoV-2 Saudi Arabia Standard of care status Symptom symptomatic mild the patient throat swab transfer treat Treatment Trial Two-arm university upper respiratory tract website written Informed Consent [DOI] 10.1186/s13063-020-04647-x PMC 바로가기 [Article Type] Letter
Impact of vitamins A, B, C, D, and E supplementation on improvement and mortality rate in ICU patients with coronavirus-19: a structured summary of a study protocol for a randomized controlled trialStudy Protocol Published on 2020-07-062022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 Abnormalities absence Ascorbate assigned baseline Biotin block BMI body temperature Chemotherapy clinical clinical trial clinical trials Complete condition control group COVID-19 CRP CT scan definitive diagnosis dissemination Duration element eligible patient ESR evaluate exclusion criteria expected female patient Folic acid Gender HIV Hospitalization Hypothesis ICU ICU patient IL6 Imam Impact IMPROVE include inclusion criteria intensive care unit Intervention invasive Iran kidneys liver lung male mortality rate New nicotinamide Non-invasive number objective organ outcome oxygen saturation pantothenate parallel group participant participated Patient patients patients with COVID-19 PCR per day percentage phosphate Placebo polymerase chain protocol pulmonary involvement randomization Randomized Randomized controlled trial Randomly receive registry renal researcher respiratory Riboflavin Sample size severity significantly sodium SpO2 Study protocol Supplementation Support table Tehran the patient thiamine nitrate TNF-α Treatment Two-arm viral disease Vitamin vitamin A Vitamin B Vitamin C Vitamin D Vitamin E WBC website weight with COVID-19 [DOI] 10.1186/s13063-020-04547-0 PMC 바로가기 [Article Type] Study Protocol