Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ FailurePharmacology Published on 2020-11-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute lung injury acute respiratory distress adverse event AEs Affect Alpha Anti-inflammatory anti-inflammatory agents ARDS Cancer clinical Clinical course Clinical practice clinical study Compliance complications coronavirus disease COVID-19 COVID-19 patient Cytokine release syndrome dose-dependent dose-escalation double-blind evaluate examined exhibited failure GRADE growth factor healthy histopathological examination Human ICH include Inflammatory cytokine ingredient interleukin-6 intravenous Liver damage Model mortality rate mouse multi-organ dysfunction multi-organ failure Necrosis New niacinamide Patient patients phosphate placebo-controlled platform Pneumonia potent Preclinical Prevent profile Protective Pulmonary edema Randomized reduce respiratory response Riboflavin SAEs Safety safety profile Sepsis Serious Adverse Event Shock show Standard statistical analysis subject subjects survival syndrome Tolerability Treatment was performed [DOI] 10.3389/fphar.2020.594321 PMC 바로가기 [Article Type] Pharmacology
A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: Is there a “lockdown” effect?Observational Study Published on 2020-11-012022-10-05 Journal: International journal of surgery (London, England) [Category] 임상, [키워드] 30-Day mortality Acute kidney injury Admission Admissions appear Cancer changes in Characteristics clinical outcomes Cohort collected Complication COVID-19 COVID-19 pandemic disease Emergency Emergency surgery evaluate gastrointestinal symptoms GRADE groups impacted increase in Inflammatory inpatient admission lockdown Lockdown effect median NHS no significant difference Observational cohort study Older operative outcomes pandemic Patient patients per day reduced reduction in severity Severity of disease significantly significantly higher significantly more surgical UK Government Volume [DOI] 10.1016/j.ijsu.2020.09.011 PMC 바로가기 [Article Type] Observational Study
Association between Physical Activity and Mood States of Children and Adolescents in Social Isolation during the COVID-19 EpidemicArticle Published on 2020-10-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] activity addition Adolescent Affect affected changes in children China Chinese correlation COVID-19 COVID-19 epidemic dropped Factor form GRADE Grade 5 group Healthcare professional help Impact investigated mental health moderate mood mood disturbance online questionnaires per day physical activity positive previous study profile School significant difference significantly significantly lower social isolation state suggested the epidemic the mean were measured [DOI] 10.3390/ijerph17207666 PMC 바로가기 [Article Type] Article
An adaptive randomised placebo controlled phase II trial of antivirals for COVID-19 infection (VIRCO): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-10-132022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 7-point ordinal scale adaptive Alfred Hospital allergy Antiviral Antiviral treatment Arm biomarkers of inflammation blinded to treatment childbearing potential clinical clinical benefit clinical symptom clinical trial Community Confirmed Contraception COVID-19 COVID-19 infection Day defined determine dialysis dissemination dose effective Efficacy element eligible enrolled enrolment Favipiravir female fertile GRADE hospitalisation hospitalised immune activation ineligible investigator male medication negative pregnancy test nucleic acid number objective outcome parallel-group participant Participants Patient performed Pharmacy Placebo protocol randomisation randomised randomised controlled trial recruit recruited recruitment renal impairment Sample size SARS-CoV-2 Screening secondary severe hepatic dysfunction Standard of care status stratified Study protocol study visit Swab Symptom the WHO time Treatment Trial triple-blind Victoria virological cure website [DOI] 10.1186/s13063-020-04766-5 PMC 바로가기 [Article Type] Letter
Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy Research Published on 2020-09-172022-10-05 Journal: Bone marrow transplantation [Category] SARS, 임상, 치료법, [키워드] CAR-T CAR-T therapy chimeric antigen receptor clinical Clinical characteristics Complication coronavirus disease correlated COVID-19 COVID-19 group CRS Cytokine release syndrome Cytokines demonstrated diagnose Disease progression dramatic increase evaluated excessive immune response GRADE had more hypertension IFN-γ IL-10 IL-2 IL-6 independent risk factor induce Inflammatory response intensity life-threatening management patients Retrospective study risk factor severe COVID-19 significantly higher significantly more T-cell therapy TNF-α Treatment Viral load [DOI] 10.1038/s41409-020-01060-5 [Article Type] Research
Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)COVID-19 치료를 위한 중재: 메타 분석 및 시험 순차 분석을 통한 살아있는 체계적인 검토(The LIVING Project)Research Article Published on 2020-09-172022-08-13 Journal: PLoS Medicine [Category] Biochemistry, COVID-19, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Admission adverse event adverse events aggregate data meta-analyses all age group all age groups all-cause mortality assessment caused certainty certainty of evidence Clinical effect Clinical research Clinical significance clinical trials Cochrane guidelines Comparisons conducted convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database development Dexamethasone driven by Effect Evidence evidence of experimental intervention Families GRADE high risk Hydroxychloroquine individual patient data meta-analyses individuals Infection intensive care International Intervention Intervention effects item Juul lack life Lopinavir Lopinavir–ritonavir mechanical ventilation meta-analyses Meta-analysis Network meta-analysis no effect no effects no evidence of nonserious adverse event nonserious adverse events on mechanical ventilation outbreak outcome outcomes participant Participants Patient patient data paucity of data performed Placebo Primary outcomes Quality of life random errors random-effects meta-analyses randomized clinical trial randomized clinical trials rapidly spreading disease rate ratio reduce reduced reducing Remdesivir renal replacement therapy replacement therapy Reporting Research researcher respiratory Respiratory failure review risk risk of bia risk of death risk ratio Ritonavir SARS-CoV-2 searched secondary Secondary outcomes Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single trial single trial randomizing Sophie Spread standard care statistically significant systematic review systematic reviews Treatment treatment for COVID-19 treatment intervention treatment of COVID-19 treatments for COVID-19 treatments of COVID-19 Trial Trial methodology trial randomizing trial sequential analyses trial sequential analysis website with COVID-19 [DOI] 10.1371/journal.pmed.1003293 PMC 바로가기 [Article Type] Research Article
Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence환기 기술 및 COVID-19를 포함한 코로나바이러스 질병 전파 위험: 여러 증거 흐름에 대한 살아있는 체계적 검토Article Published on 2020-08-042022-09-11 Journal: Annals of internal medicine [Category] SARS, 비임상, [키워드] acute respiratory syndrome adjusted aerosol-generating procedure aerosol-generating procedures AGPs animal approach benefit breath certainty certainty of evidence confounders coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 Direct eligible Evidence GRADE Health care Health care worker health care workers Health Organization hospitalized patient hospitalized patients hypoxemic Hypoxemic respiratory failure IMV Including independent Invasive mechanical ventilation Laboratory language Mechanical mechanical ventilation MERS Middle East Middle East respiratory syndrome Mortality Multiple NIV Noninvasive ventilation Other oxygen Oxygen therapy Oxygenation Patient patients with SARS PROSPERO reduce reduction in mortality reported respiratory Respiratory failure review risk Severe acute respiratory syndrome stream syndrome systematic review systematic reviews technique Transmission treat Ventilation virus transmission with COVID-19 World Health Organization [DOI] 10.7326/M20-2306 PMC 바로가기 [Article Type] Article
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trialACCORD: 입원 환자의 COVID-19 치료를 위한 여러 후보 약제의 효능과 안전성을 평가하기 위한 다기관, 원활한, 2상 적응형 무작위화 플랫폼 연구: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-07-312022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 a BTK inhibitor Acalabrutinib adaptive added adjusted agent Amendment analyses Analysis Anti-viral approval Arm baseline bemcentinib Blinding block BTK inhibitor candidate Candidates cause caused changed clinical Clinical characteristics Clinical improvement clinically comparator complement COVID COVID-19 current Day discharge disease dissemination dropped Efficacy element Endpoint England estimation EudraCT evaluate Evidence evidence of experimental arm GRADE group help heparin hospital hospitalised include Inflammatory response inhibitor Ireland IRT Mask Master protocol Mild Mild disease monoclonal antibody Multiple nasal prongs National non-invasive ventilation number objective open open label Ordinal Scale outcome oxygen Oxygen therapy oxygen therapy) participant Patient performed Phase 2 phase II platform proceed protocol protocols provide randomisation randomised randomised controlled randomised controlled trial randomization recruited recruitment reduce Registered Regulatory reported Respiratory failure response response rate Safety Sample size SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein seamless selected severity shown SOC Spike protein Stage stage 2 stages Standard of care status stratified Study protocol sustained Task Force technology the spike protein the WHO therapy time treat Treatment treatment of COVID-19 Trial Trial registration Viral viral infection virus website with COVID-19 working zilucoplan [DOI] 10.1186/s13063-020-04584-9 PMC 바로가기 [Article Type] Letter
Preventive effectiveness of varicella vaccine in healthy unexposed patientsMeta-Analysis Published on 2020-07-302023-06-01 Journal: Medwave [Category] 두창, 수두, 홍역, [키워드] Chickenpox Epistemonikos GRADE Vaccine varicella [DOI] 10.5867/medwave.2020.06.7982 [Article Type] Meta-Analysis
Preventive effectiveness of varicella vaccine in healthy unexposed patientsMeta-Analysis Published on 2020-07-302023-06-01 Journal: Medwave [Category] 두창, 수두, 홍역, [키워드] Chickenpox Epistemonikos GRADE Vaccine varicella [DOI] 10.5867/medwave.2020.06.7982 [Article Type] Meta-Analysis