hACE2 – Page 9 – Communicable Diseases Research

The vital role of animal, marine, and microbial natural products against COVID-19

Covid-19에 대한 동물, 해양 및 미생물 천연 제품의 중요한 역할

Review

Published on 2022-03-022022-09-10
Journal: Pharmaceutical Biology [Category] 신약개발, 치료제,

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

Article

Published on 2022-02-172023-07-07
Journal: Cell [Category] COVID19(2023년),

[키워드] Delta hACE2 omicron RBD Receptor-binding domain Structure variants of concern VOCs
[DOI] 10.1016/j.cell.2022.01.001 PMC 바로가기

A Simplified SARS-CoV-2 Mouse Model Demonstrates Protection by an Oral Replicon-Based mRNA Vaccine

단순화된 SARS-CoV-2 마우스 모델은 경구 레플리콘 기반 mRNA 백신에 의한 보호를 보여줍니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] addition Adenovirus angiotensin anti-SARS-CoV-2 carried characteristic cross-protective determine domain drug epitope Epitopes expressing expression forest gene delivery glycoprotein hACE2 heptad repeat human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunized mice immunohistochemistry in vitro in vivo Infectious disease Infectious diseases interstitial pneumonia lab lung Lung disease Lung pathology Lungs Macrophage macrophages membrane membrane glycoprotein mice Model moderate Molecular biology mouse mouse model mRNA mRNA expression mRNA vaccine murine Neutralizing antibodies neutralizing antibody nine nsp13 oral parental peptide peptides protection purification qPCR RBD Receptor binding domain recorded RT-PCR Salmonella SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mouse model Support supported target the SARS-CoV-2 therapy transduced transducing transduction utility Vaccine Vaccine design Vaccines variant Viral viral replication virus was determined weight loss were assessed
[DOI] 10.3389/fimmu.2022.811802 PMC 바로가기 [Article Type] Immunology

Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests

신속한 항원 테스트를 사용하여 활성 COVID-19 감염의 효율적인 진단을 위한 콩 추출물 기반 가글

Research Article

Published on 2022-02-162022-09-10
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] Ag-RDT Ag-RDTs Alpha alpha and delta variants alternative analyzed Antigen Asymptomatic Bean canavalin clinical trial Concentration COVID-19 COVID-19 cases COVID-19 patient COVID-19 patients Delta delta variant Delta variants Detachment Detection sensitivity diagnostic diagnostic test domain early diagnosis efficient ENhance evaluated Evidence gargle hACE2 healthy individual healthy individuals ingredient initial intermolecular interaction intermolecular interactions less management Mass screening Nasopharyngeal swab nasopharyngeal swabs noninvasive NPs oral virus Patient patients hospitalized Physicochemical properties Rapid Rapid diagnostic test RDTs RT-PCR saliva specimen saliva specimens salivary SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 variant screening process sensitivities sensitivity significantly Specificities specificity Spike proteins symptomatic symptomatic and asymptomatic Test tested the SARS-CoV-2 variants Viral Viral detection virus
[DOI] 10.1128/spectrum.01614-21 PMC 바로가기 [Article Type] Research Article

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

Research

Published on 2022-02-162022-10-05
Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘,

SARS-CoV-2 variants of concern display enhanced intrinsic pathogenic properties and expanded organ tropism in mouse models

우려되는 SARS-CoV-2 변이체는 마우스 모델에서 향상된 고유 병원성 특성 및 확장된 기관 친화성을 나타냅니다.

Article

Published on 2022-02-152022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] accelerated ACE2 receptor Alpha Alpha variant Antibody neutralization Beta Beta variant cellular cellular immunity curtail cytokine cytokine production Depletion disease Disease progression elicit expand Gamma Gamma variant gastrointestinal tract hACE2 host range human ACE2 immune activation immune responses induce Infection Inflammation innate immune response interferon intrinsic ISG ISG expression K18-hACE2 lung Lungs management mice mouse model murine Natural killer cells neutralization organ pandemic pathogenic pathogenicity reduced replicate responses reveal SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread Symptoms systemic infection tissue transgenic Transmissibility Trigger variants variants of concern VoC VOCs wild-type zoonotic transmission
[DOI] 10.1016/j.celrep.2022.110387 PMC 바로가기 [Article Type] Article

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2

Article

Published on 2022-02-112022-10-28
Journal: Pathogens [Category] COVID-19,

Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants

Coronaviruses

Published on 2022-02-102022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro

Coronaviruses

Published on 2022-02-102022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS,

[키워드] Acidic acute respiratory syndrome Affect antiviral activity Antiviral compound approach B.1.1.7 B.1.351 B.1.617.2 Beta blocked cathepsin L caused Cell clinical virus isolates Compound Concentration coronavirus Coronavirus disease 2019 COVID-19 cysteine protease Delta effective endocytosis Endosomal acidification enzymatic activity expressing furin furin protease global pandemic hACE2 HIV human Angiotensin-converting enzyme human lung in vitro inhibit intestinal cell MCL-1 mechanisms membrane fusion Obatoclax prevented Protein pseudotype reducing reporter S protein Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike SARS-CoV-2 variant set off suggested the SARS-CoV-2 Treatment unmet need virion virus virus entry
[DOI] 10.1080/22221751.2022.2026739 PMC 바로가기 [Article Type] Coronaviruses

Targeting the RBD of Omicron Variant (B.1.1.529) with Medicinal Phytocompounds to Abrogate the Binding of Spike Glycoprotein with the hACE2 Using Computational Molecular Search and Simulation Approach

Article

Published on 2022-02-072022-10-28
Journal: Biology [Category] COVID-19,

[키워드] acute respiratory syndrome African Analysis Anti-viral anti-viral agent B.1.1.529 binding binding free energy Bioactivity bioinformatics claimed complex Compound coronavirus database demonstrated drug drugs hACE2 help in silico inhibitor Interaction MD simulations medicinal plants molecular Mutation natural Neutralizing antibodies omicron other variant performed RBD reduced reported required SARS-CoV-2 simple Simulation South South Africa spike spike-ACE2 targeting the binding affinity the RBD the receptor-binding domain the spike protein these compound these compounds variant variant of SARS-CoV-2 virus VOCs
[DOI] 10.3390/biology11020258 PMC 바로가기 [Article Type] Article