Are Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?Medicine Published on 2021-09-302022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission association Coagulation Coagulation factors Coagulation system COVID-19 COVID-19 patient COVID-19 severity cross-sectional study CRP death Diagnosis disorder Evaluating Factor healthy control healthy individuals higher risk highest immunoassay increased risk individuals Invitrogen Level moderate Moderate COVID-19 Mortality multiplex Panel Patient patients plasma progression Protein provoke reached recruited reported SARS SARS-CoV-2 severe disease severity survival were measured with COVID-19 [DOI] 10.3389/fmed.2021.718053 PMC 바로가기 [Article Type] Medicine
Calcifediol Treatment and COVID-19-Related OutcomesObservational Study Published on 2021-09-272022-10-05 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] SARS, 임상, [키워드] 25-hydroxyvitamin D 95% CI adjusted Admission age Analysis Barcelona baseline calcifediol calcifediol treatment Comorbidity conducted COVID-19 died Health healthy individuals Hospital admission ICU ICU admission intensive care unit intention-to-treat intention-to-treat analysis Mortality mortality risk Observational cohort study Odds ratio outcome measure outcomes Participants Patient patients hospitalized patients treated patients with COVID-19 Potential treatment reduce reduced reduced risk required severity Sex significantly Spain the disease treated treated patient Treatment Vitamin D were excluded with COVID-19 [DOI] 10.1210/clinem/dgab405 PMC 바로가기 [Article Type] Observational Study
Identifying individuals with recent COVID-19 through voice classification using deep learning딥러닝을 이용한 음성 분류를 통해 최근 코로나19 감염자 식별Article Published on 2021-09-272022-09-10 Journal: Scientific Reports [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Biomarkers change in voice classification collected Convolutional neural network Convolutional neural networks coughing COVID-19 COVID-19 patient COVID-19 patients deep learning detect diagnose diagnoses disease feature healthy individuals highest identifying individual lowest Medical research onset of symptoms predict produced Prospective Study sensitivity sound specificity the disease voice was performed [DOI] 10.1038/s41598-021-98742-x PMC 바로가기 [Article Type] Article
Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy항-CD20 요법을 받고 있는 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신 접종 후 세포 및 체액 면역 반응Article Published on 2021-09-142022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] activated ameliorated anti-CD20 anti-CD20 therapy Anti-RBD IgG antibodies antibody Antigen antigen-specific antibody B cell BNT162b2 breath CD4 CD8 CD8 T cell CD8 T cell responses Cell circulating COVID-19 domain follicular generate Health policy healthy control healthy controls healthy individuals humans humoral immune response immune immune protection immune responses Immunosuppressed immunosuppressed patient immunosuppressed patients implication in healthy individual investigated memory B memory B cell memory B cells Messenger RNA monoclonal antibody monotherapy Most patients mRNA mRNA vaccination mRNA vaccine mRNA-1273 multiple sclerosis Patient patients priming public health Receptor-binding domain reduced response responses RNA vaccines robust SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody significantly skewed specific antibodies T cell T cell response T cell responses T cells the SARS-CoV-2 These data treated Treatment type 1 helper vaccination vaccine-induced immune response [DOI] 10.1038/s41591-021-01507-2 PMC 바로가기 [Article Type] Article
High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study높은 에스트라디올과 낮은 테스토스테론 수치는 남성의 심각한 질병과 관련이 있지만 여성의 COVID-19 환자와는 관련이 없습니다: 후향적 코호트 연구Original Article Published on 2021-09-142022-09-10 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 치료기술, [키워드] Admission analysed chemokine chemokines cohorts Comorbidity COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients Critical Critical illness Critically ill cytokine Cytokines death disease severity ECMO elevated estradiol estradiol level female hallmark healthy individual healthy individuals Heart diseases ICU IFN-γ intensive care intensive care unit Linear regression analysis male metabolism non-COVID-19 patient Non-COVID-19 patients prevalent receive reduced regression analysis retrospective cohort study risk factor SARS-CoV-2 Sex sex differences sex hormone Sex hormones significantly statistically significant difference Testosterone Treatment [DOI] 10.1080/22221751.2021.1969869 PMC 바로가기 [Article Type] Original Article
Physical Activity Reduction and the Worsening of Gastrointestinal Health Status during the Second COVID-19 Home Confinement in Southern ItalyArticle Published on 2021-09-102022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] 95%CI activity Apulia association Calabria Campania change Christma consequence COVID-19 COVID-19 pandemic Diseases Energy expenditure females Gastrointestinal gastrointestinal tract GI symptoms GI Tract Government Health Health status healthy individuals healthy subject home increase in Italian Italy offered physical activity reduce reduced scale second severity statistical significance statistically significant status subject subjects Support survey platform Symptoms total score WhatsApp worsening [DOI] 10.3390/ijerph18189554 PMC 바로가기 [Article Type] Article
TIM‐3 as a potential exhaustion marker in CD4 + T cells of COVID‐19 patientsCOVID-19 환자의 CD4 + T 세포에서 잠재적인 피로 마커로서의 TIM-3Original Article Published on 2021-09-092022-09-10 Journal: Immunity, Inflammation and Disease [Category] SARS, 치료기술, [키워드] Blood Blood urea nitrogen C‐reactive protein calculated cause CD39 CD4 clinical information clinical symptom Clinical symptoms collected COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 creatinine Critical critical patients deaths disease erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Exhausted cell flow cytometry group groups healthy individuals in healthy individual laboratory data lymphocyte Lymphocytes lymphopenia marker Mild mononuclear cell mononuclear cells neutrophil neutrophil count nitrogen occur overexpression Patient patient groups PBMCs PD‐1 PD‐1 peripheral Peripheral blood Peripheral blood mononuclear cells Result sedimentation rate significant difference significantly higher subjects subpopulation T cell T cells TIM‐3 urea [DOI] 10.1002/iid3.526 PMC 바로가기 [Article Type] Original Article
Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 SymptomatologyCOVID-19 증상에 대한 면역 관련 예후 바이오마커의 정량적 혈청 단백질체학에 의한 특성화Immunology Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] affecting Algorithm Analysis Asymptomatic biological processe Biomarker Biomarkers caused characterization Cohort contribute contributed correlated COVID-19 COVID-19 disease COVID-19 pandemic Data analysis diagnostic disease Disease progression disease progression and severity disease symptom disease symptoms disorder disorders dysregulated ELISA Factor FIVE healthy healthy individual healthy individuals hospital discharge Hospitalized immunology increase intensive care intensive care unit molecular interaction pandemic physiological PON1 Predictive Predictive value profile prognostic prognostic biomarker Prognostic biomarkers Protein proteomic proteomics Quantitative representation SARS-CoV-2 selected SELENOP Selenoprotein P Serum protein serum proteins severe cases severity significantly Symptomatology systemic inflammation therapeutic intervention translational with COVID-19 zone [DOI] 10.3389/fimmu.2021.730710 PMC 바로가기 [Article Type] Immunology
Alteration in Nasopharyngeal Microbiota Profile in Aged Patients with COVID-19Brief Report Published on 2021-09-052022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory syndrome affecting alteration Analysis analyzed Asymptomatic Bacterial cause contributing to coronavirus coronavirus disease correlation COVID-19 COVID-19 positive patient COVID-19 severity cytokine develop droplet examined FIVE groups healthy individuals identify immune response individual Infectious virus Lungs mechanism microbiota nasal nasopharyngeal nasopharyngeal profile in aged patients with COVID-19 infection and severity nasopharynx P -value Patient patients patients with COVID-19 positive profile respiratory tract severe symptoms severity of COVID-19 significantly significantly lower susceptible Swab symptomatic therapeutic strategy transmitted with COVID-19 [DOI] 10.3390/diagnostics11091622 PMC 바로가기 [Article Type] Brief Report
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues정상 및 SARS-CoV-2에 감염된 인간 조직에서 TMPRSS2 발현의 전산 분석Article Published on 2021-09-012022-09-11 Journal: Chemico-biological interactions [Category] 유전자 메커니즘, [키워드] acute respiratory illnesses Analysis analyzed B cells Cancer CD8 Cell cell growth co-expression correlated correlation cytokine datasets epididymis expression female G-CSF gene co-expression network Gene expression profiles Gene ontology growth healthy individuals high expression level highest human host cells human tissue human tissues IFN-α IL-1 IL-12 IL-18 IL-2 IL-4 IL-7 IL-8 immune immune signature Immune signatures in healthy individual interferon interferon response investigated involved IP-10 kidneys Lungs male MCP-1 mechanism metabolism Nasopharyngeal swab nasopharyngeal swabs NK cells no significant difference normal lung tissue not significantly different Older older patients older population other diseases pancreas parathyroid Parathyroid gland pathway Pathway and gene ontology Pathways Patient performed Population positive positively correlated potential mechanism proliferation Prostate salivary salivary gland SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients seminal vesicle Serine serine protease significantly lower small intestine stomach T cells tissue tissues TMPRSS2 TMPRSS2 expression TMPRSS2 expression level TMPRSS2 expression levels TMPRSS2 protein TNF-α transmembrane serine protease transmembrane serine protease 2 Vesicle [DOI] 10.1016/j.cbi.2021.109583 PMC 바로가기 [Article Type] Article