PSSPNN: PatchShuffle Stochastic Pooling Neural Network for an Explainable Diagnosis of COVID-19 with Multiple-Way Data AugmentationPSSPNN: 다중 방식 데이터 증강을 통해 설명 가능한 COVID-19 진단을 위한 PatchShuffle 확률적 풀링 신경망Research Article Published on 2021-03-082022-09-12 Journal: Computational and Mathematical Methods in Medicine [Category] 진단, [키워드] Algorithm approaches assist augmentation caused COVID-19 COVID-19 cases death Diagnosis early treatment FIVE healthy subjects help introduced network Neural nine Pneumonia pooling pulmonary tuberculosis radiologist random Result second stochastic was used [DOI] 10.1155/2021/6633755 PMC 바로가기 [Article Type] Research Article
COVID-19 salivary Raman fingerprint: innovative approach for the detection of current and past SARS-CoV-2 infectionsCOVID-19 타액 라만 지문: 현재 및 과거 SARS-CoV-2 감염 감지를 위한 혁신적인 접근 방식Article Published on 2021-03-022022-09-01 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, [키워드] Accuracy Analysis approach biochemical collected Computational biology and bioinformatics COVID-19 COVID-19 patient COVID-19 patients creation Data processing deep demonstrated diagnostic Diagnostic markers Efficacy epidemiological groups healthy subject healthy subjects implication Infection invasive learning Modification modifications pandemic of COVID-19 Patient Precision Predictive markers regions Saliva salivary SARS-COV-2 infection Sensitivity and specificity signal significantly subject translate [DOI] 10.1038/s41598-021-84565-3 PMC 바로가기 [Article Type] Article
Increased kynurenine-to-tryptophan ratio in the serum of patients infected with SARS-CoV2: An observational cohort studySARS-CoV2에 감염된 환자의 혈청에서 키누레닌 대 트립토판 비율 증가: 관찰 코호트 연구Observational Study Published on 2021-03-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 바이오마커, 임상, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome addition age balance Biomarker Cytokines death dysregulation Emergency emergency room examined hallmark healthy controls healthy subject healthy subjects highest HPLC immune immune dysregulation immune reactivity immune tolerance increase in Increased Infection Inflammation inflammatory state intensive care intensive care unit Italy Kynurenine Kynurenine pathway Kynurenine:Tryptophan ratio lymphopenia males mechanism metabolism Observational cohort study Patient patients positive patients positively correlated pro-inflammatory cytokine pro-inflammatory cytokines reactivity recruited reflect respiratory distress Respiratory distress syndrome Rome room SARS-CoV2 SARS-CoV2 infection serum Serum level severe lymphopenia severity Severity of infection Severity of infection. significant difference Stage syndrome therapeutic intervention Tolerance Tryptophan were assessed [DOI] 10.1016/j.bbadis.2020.166042 PMC 바로가기 [Article Type] Observational Study
Functional Exhaustion of Type I and II Interferons Production in Severe COVID-19 PatientsMedicine Published on 2021-01-272022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adaptive Adaptive immune response Admission Asymptomatic carried caused Complication complications coronavirus Coronavirus disease 2019 correlated Course COVID-19 COVID-19 patient COVID-19 patients cytokine level cytokine levels Cytokine storm Cytokines described develop disease severity Exhaustion Follow-up form functional healthy subjects highlight hospital Hospitalization identify IFN IFNs IFNα IFNγ IFNγ level IL1β IL6 IL8 Immune cell immune cells immune factor immunological profile immunology in vitro independent Infectious diseases Inflammatory Inflammatory cytokine interferon majority Mild moderate multivariable analysis non-specific observation outcome Patient Personalized medicine plasma Potential biomarker pro-inflammatory cytokine Production Prospective Study reduced remained restored SARS-CoV-2 secretion severe COVID-19 patient significantly increased Spread Th1 the disease the WHO TNFα Treatment Type type I type II IFN type II interferon were measured Wuhan [DOI] 10.3389/fmed.2020.603961 PMC 바로가기 [Article Type] Medicine
Altered high-density lipoprotein composition and functions during severe COVID-19심각한 COVID-19 동안 변경된 고밀도 지단백질 구성 및 기능Article Published on 2021-01-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, [키워드] Admission affecting Alpha Altered amyloid A Analysis Anti-inflammatory antioxidant antitrypsin Apolipoprotein Apoptosis Biomarkers cadherin changes in conditions consequence controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Day Decreased Endothelial cell endothelial cells exposure to function HDL HDL-C HDLs healthy subjects high-density initial intensive care intensive care unit less lipid metabolism mass spectrometry pandemic Particle Patient patients worldwide permeability plasma Protective Protein proteome Proteomic analysis proteomics pulmonary damage reported SARS-CoV-2 serum amyloid severe COVID-19 severe COVID-19 patient severe COVID-19 patients Sex TNFα VE-cadherin viral infection was performed [DOI] 10.1038/s41598-021-81638-1 PMC 바로가기 [Article Type] Article
Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8 + T cellsResearch Articles Published on 2021-01-212022-10-28 Journal: Science Immunology [Category] COVID-19, [키워드] Analysis anti-apoptotic CD8 Cell COVID-19 patient cytotoxicity disease dominant enrichment feature Frequency Glycolysis healthy control healthy subject healthy subjects Inflammatory Influenza memory Mild molecular NF-κB signaling Pathways Patient reactive respiratory syncytial virus respond response robust SARS-CoV-2 SARS-COV-2 infection severe COVID-19 illness severe disease single-cell single-cell transcriptome subset T cell T cell memory T cell response T cells transcript two group [DOI] 10.1126/sciimmunol.abe4782 PMC 바로가기 [Article Type] Research Articles
Noncontact Body Temperature Measurement: Uncertainty Evaluation and Screening Decision Rule to Prevent the Spread of COVID-19비접촉 체온 측정: 코로나19 확산 방지를 위한 불확실성 평가 및 선별 판정 규칙Article Published on 2021-01-062022-09-12 Journal: Sensors (Basel, Switzerland) [Category] MERS, 진단, [키워드] adopted alternative approach Body body temperature clinical thermometer Contact Contagion COVID-19 COVID-19 pandemic Critical decision healthy subjects IMPROVE Infrared thermometer infrared thermometers limit limits National obligation protocol provide reference values risk rule Screening screening protocol skin emissivity skin temperature spread of COVID-19 subjectivity temperature threshold Uncertainty widespread Workplace [DOI] 10.3390/s21020346 PMC 바로가기 [Article Type] Article
Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19인터루킨-18의 예후 가치와 코로나19의 다른 염증 표지자 및 질병 중증도와의 연관성Article Published on 2021-01-012022-09-11 Journal: Cytokine [Category] MERS, 바이오마커, [키워드] Admission age and sex analyzed antagonist antagonists approach association Asymptomatic biochemical marker biochemical markers blood sample Blood samples Care Characteristics Clinical characteristics clinical trial clinical trials collected Concentration consequence control group correlated COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients creatinine CRP cut off value cytokine Cytokines D-dimer death defined demographic and clinical characteristics determined by detrimental Diagnosis died dimer disease disease severity ELISA enrolled Enrollment Evidence feature ferritin healthy subject healthy subjects highest hospital discharge ICU ICU admission IL-18 IL-6 immune response increased risk individual Inflammatory marker inflammatory markers intensive care intensive care unit interleukin Interleukin-18 Laboratory lead liver enzyme liver enzymes Macrophage macrophage activation syndrome male median age Mild mild pneumonia nine nucleic acid on admission organ organ injury outcome Patient Pneumonia procalcitonin Prognosis radiological required Result RT-PCR SARS-CoV-2 nucleic acid serum serum concentrations Serum level serum levels severe COVID-19 patients severe group severe pneumonia study population three group three groups Treatment troponin Viral viral infections were measured with COVID-19 [DOI] 10.1016/j.cyto.2020.155302 PMC 바로가기 [Article Type] Article
A Treatment to Eliminate SARS-CoV-2 Replication in Human Airway Epithelial Cells Is Safe for Inhalation as an Aerosol in Healthy Human Subjects인간 기도 상피 세포에서 SARS-CoV-2 복제를 제거하는 치료법은 건강한 인간 대상에서 에어로졸로 흡입하기에 안전합니다Article Published on 2021-01-012022-08-31 Journal: Respiratory care [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] Activation aerosol airway Airway inflammation airway pH. Cell cells clinical trial Concentration COVID-19 Defense determine Diseases endosomal trafficking expression had no healthy subjects Host host defense Human human airway epithelial humans impair in vivo Infection inhalation Inhaled inhibited isotonicity Lung function mechanisms multiplicity multiplicity of infection N protein no effect nucleocapsid osmolality Oxygenation Patient patient safety phase Placebo Plaque assay Prevent prevented protein levels raise raised Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral replication subject subjects Treatment Trial USA-WA1/2020 viability Viral viral infection viral replication vital signs was determined [DOI] 10.4187/respcare.08425 PMC 바로가기 [Article Type] Article
Effects of face masks on acoustic analysis and speech perception: Implications for peri-pandemic protocols a)Special Issue on Covid-19 Pandemic Acoustic Effects Published on 2020-12-102022-10-31 Journal: The Journal of the Acoustical Society of America [Category] Coronavirus, MERS, SARS, [키워드] Accuracy Acoustic Affect affected Analysis assessment cloth masks condition COVID-19 distribution Effect examined face Face mask feature Frequency healthy subjects impacted Infection Intelligibility investigated Mask Masks measure Personal protective equipment physical distancing protocol provide remained speech surgical translation wearing were measured [DOI] 10.1121/10.0002873 PMC 바로가기 [Article Type] Special Issue on Covid-19 Pandemic Acoustic Effects