Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and TransmissionMicrobiology Published on 2021-10-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome ADAR analyzed APOBEC association Asymptomatic Beta clinical Clinical outcome Complete coronavirus coronavirus 2 coronavirus disease correlated COVID-19 Critical D614G enzyme Epidemic expression Frame Frequency Gamma GISAID database hotspot mechanism Mild mild case Mutation mutation hotspots mutations occur occurred ORF1ab outcome pandemic predict Prevalence Q57H RdRP respiratory RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 sequence severe cases severe disease shown single-nucleotide SNV strain Strains symptomatic the SARS-CoV-2 the SARS-CoV-2 genome Treatment understanding variant [DOI] 10.3389/fmicb.2021.753823 PMC 바로가기 [Article Type] Microbiology
Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide전 세계적으로 SARS-CoV-2의 기원, 계통 발생, 가변성 및 에피토프 보존Article Published on 2021-10-152022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid change amino acid changes analyzed antibodies caused Cluster Comparative genomics conserved contributed coronavirus Coronavirus comparative genomics coronavirus disease Coronavirus disease 2019 COVID-19 distribution Efficacy epitope epitope conservation Epitope prediction Epitopes Evidence evidence of favor GenBank Genome genomes Geographic distribution GISAID database hotspot identify Multiple Mutation N protein nucleotide ORF origin pandemic pangolin Phylogeny predicted primary structure Protein Recombination Region RNA virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomics severe acute respiratory syndrome Coronavirus Single nucleotide variant SNV SNVs spike spike gene spike glycoprotein Spike protein structural proteins target targets the spike protein triggered Vaccine vaccine efficacy Variability variable variant viral genome virus VoC VOCs [DOI] 10.1016/j.virusres.2021.198526 PMC 바로가기 [Article Type] Article
Misalignment between COVID-19 hotspots and clinical trial sitesCOVID-19 핫스팟과 임상 시험 장소 간의 불일치Article Published on 2021-10-122022-09-11 Journal: Journal of the American Medical Informatics Associ [Category] SARS, 임상, [키워드] alignment Analysis clinical Clinical research clinical research informatics clinical trial clinical trial site location combating coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case effective Enrollment evaluate fraction Future hotspot identify Metrics pandemic recruitment Research the United State Treatment treatment strategy Trial trial recruitment. trials United States worsened [DOI] 10.1093/jamia/ocab167 PMC 바로가기 [Article Type] Article
COVID-19 hotspots through clusters analysis in France (may–October 2020): where should we track the virus to mitigate the spread?프랑스 클러스터 분석을 통한 Covid-19 핫스팟 (2020 년 5 월 -10 월) : 스프레드를 완화하기 위해 바이러스를 어디에서 추적해야합니까?Research Article Published on 2021-10-112022-09-10 Journal: BMC Public Health [Category] MERS, SARS, 변종, 치료기술, 치료제, [키워드] affected Analysis Care chi-square tests Cluster Clusters Community COVID-19 COVID-19 cases Criticality database defined Descriptive analysis Early detection First wave followed by France Health Health care health care facilities highlight hotspot Hotspots lifting lockdown majority mitigate National new SARS-CoV-2 occurred Occurrence participated public health recommendation Registered reported Result risk Seven shift significant difference significant differences Structure study period summer Surveillance sustained Transmission typology vaccination variant virus [DOI] 10.1186/s12889-021-11857-8 PMC 바로가기 [Article Type] Research Article
Second wave of COVID-19: emergency situation in IndiaCOVID-19의 두 번째 물결: 인도의 비상 상황Article Published on 2021-10-112022-09-11 Journal: Journal of Travel Medicine [Category] SARS, 변종, [키워드] approach B.1.1.7 B.1.351 B.1.617 circulating country COVID-19 COVID-19 pandemic emergency situation hotspot include India lockdown mass vaccination Mutation pandemic second second wave vaccination variant [DOI] 10.1093/jtm/taab082 PMC 바로가기 [Article Type] Article
Community-based surveillance contribution to the response of COVID-19 in NigerResearch Published on 2021-10-112022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, SARS, [키워드] adaptive added addition analysed case-findings CBS Community complement Contact tracing Control country COVID-19 COVID-19 pandemic death Disease surveillance Health Health Service health systems health worker hotspot IDSR IMPROVE individual Integrated disease surveillance and response Niger people centered-surveillance polio positive COVID-19 raise regions reported Result resulting SARS-CoV-2 sensitivity Spread Surveillance System [DOI] 10.11604/pamj.2021.40.88.28175 PMC 바로가기 [Article Type] Research
Children’s Privilege in COVID-19: The Protective Role of the Juvenile Lung Morphometry and Ventilatory Pattern on Airborne SARS-CoV-2 Transmission to Respiratory Epithelial Barriers and Disease SeverityArticle Published on 2021-10-082022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] aerosol Aerosols age alveolar–interstitial region anatomical barrier Characteristics children clinical manifestation Clinical symptoms determine droplets epithelial Evidence explain help hotspot in silico incidence Infection initial innate immune response intrinsically investigated Juvenile Lower respiratory tract lower risk lung mechanism Pathogenesis pathophysiology pattern pediatric Pneumonia Privilege pulmonary disease respiratory respiratory tissue risk factor role SARS-CoV-2 SARS-CoV-2 susceptibility self-limiting disease severe COVID-19 severity Thoracic upper respiratory ventilatory [DOI] 10.3390/biomedicines9101414 PMC 바로가기 [Article Type] Article
Antimalarial-agent artemisinin and derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine: potential repurposing of artenimol for COVID-19Article Published on 2021-10-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] addition Analysis Antiviral Artemisinin artesunate binding Clinical studies complexes Compound COVID-19 derivative docking score effective hACE2 hotspot Human Hydroxychloroquine inhibitor Interaction interfere molecular docking studies molecular dynamics produced Protein protocol SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 spike protein spike Spike protein targets the Spike Treatment [DOI] 10.1080/07391102.2020.1796809 PMC 바로가기 [Article Type] Article
District level correlates of COVID-19 pandemic in India during March-October 2020Research Article Published on 2021-09-302022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] affecting association carried children Clustering COVID-19 COVID-19 case COVID-19 infection COVID-19 pandemic death demographic characteristics demonstrated District Gujarat highest highlight hotspot India infected case Infection information lowest nine objective positive regression analysis Result significantly understanding Variation West [DOI] 10.1371/journal.pone.0257533 PMC 바로가기 [Article Type] Research Article
Key Interacting Residues between RBD of SARS-CoV-2 and ACE2 Receptor: Combination of Molecular Dynamics Simulation and Density Functional CalculationSARS-CoV-2의 RBD와 ACE2 수용체 간의 주요 상호 작용 잔류물: 분자 역학 시뮬레이션과 밀도 함수 계산의 조합Article Published on 2021-09-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor Alpha Alpha variant Amino acid Analysis atomic level Beta Beta variant bind binding binding free energy calculation complex density Density functional theory determine domain driving Dynamics E484K electrostatic ENhance free energy functional hotspot hydrogen hydrophobic hydrophobic interaction identify implementation increase K417N molecular molecular dynamics Molecular mechanics molecular target N501Y N501Y mutation performed predict presenting proliferation protocol RBD RBD of SARS-CoV-2 RBD-ACE2 Receptor-binding domain reduce residue responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS2 significantly Simulation Spike protein surface area Tight binding Vaccine development variant variants virus infection wild-type [DOI] 10.1021/acs.jcim.1c00560 PMC 바로가기 [Article Type] Article