Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S GlycoproteinsCommunication Published on 2020-09-292022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 ACE2-Fc acute respiratory syndrome anti-SARS-CoV-2 therapeutics binding conformational coronavirus coronavirus disease COVID-19 CR3022 antibody deaths exhibit glycoprotein Human human ACE2 receptor human Angiotensin-converting enzyme infecting Interaction investigated membrane-bound monomeric neutralization pandemic positive receptor required responsible S glycoproteins SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S soluble ACE2 spike glycoproteins spike trimers the receptor-binding domain the SARS-CoV-2 trimeric spike viral entry virus [DOI] 10.3390/v12101104 PMC 바로가기 [Article Type] Communication
Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactionsResearch Article Published on 2020-09-242022-10-27 Journal: AIMS Microbiology [Category] COVID-19, [키워드] ACE2 attribute C-terminal cleavage Characteristics cleavage cleavage site cleavage sites complex conformational COVID-19 directional docked docking driven by drug target etiological agent full length functional host cell human ACE2 receptor interact Interaction intermolecular interaction molecular molecular docking N-terminal predicted priming provide residue resolved responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein serine protease Spike protein the SARS-CoV-2 the spike protein TMPRSS2 viral spike protein [DOI] 10.3934/microbiol.2020021 PMC 바로가기 [Article Type] Research Article
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopesArticle Published on 2020-08-272022-10-29 Journal: Nature Communications [Category] COVID-19, [키워드] acute phase antibody approved binding collected coronavirus SARS-CoV-2 COVID-19 pandemic described domain epitope human ACE2 receptor Human monoclonal antibody Immunotherapy in vitro inhibitory activity Isolation lymphocyte mAb multiple epitope Neutralizing Neutralizing activity neutralizing antibody neutralizing monoclonal antibody Patient RBD Receptor binding domain recognize SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected shown subset the antibody the disease the RBD the SARS-CoV-2 therapeutic drug therapy viral infection viral spike virus [DOI] 10.1038/s41467-020-18159-4 PMC 바로가기 [Article Type] Article
Evolutionary and structural analyses of SARS-CoV-2 D614G spike protein mutation now documented worldwideArticle Published on 2020-08-202022-10-04 Journal: Scientific Reports [Category] MERS, 변종, [키워드] Analysis applied association bioinformatics caused clade Clinical outcome coronavirus 2 COVID-19 case COVID-19 pandemic D614G deaths diagnosed disease severity Epidemiology Europe Evolution Evolutionary genetics Future genomic human ACE2 receptor Infectious diseases Interaction Johns Hopkins lack Metadata Microbial genetics Missense mutation MONITOR Mutation Neutral pandemic performed phenotype Phylogenetic analysis predominant prevented Protein respiratory SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 genome SARS-CoV-2 strain sequenced Spike protein the spike protein viral clade virulence virus World Health Organization [DOI] 10.1038/s41598-020-70827-z PMC 바로가기 [Article Type] Article
Analysis of ACE2 Gene-Encoded Proteins Across Mammalian SpeciesVeterinary Science Published on 2020-07-032022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] ACE2 ACE2 gene acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 binding caused chronic disease close contact coded coronavirus coronavirus disease correlation COVID-19 Data analysis Felis homologous homology host cell Human human ACE2 receptor humans immunosuppressive Infection infection process mammalian mammals novel Novel coronavirus Pneumonia predicted Predictive Protein public health Rattus receptor required SARS-CoV-2 Specy spike-protein suggested susceptibility susceptible Transmission virus [DOI] 10.3389/fvets.2020.00457 PMC 바로가기 [Article Type] Veterinary Science
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?Hypothesis Published on 2020-05-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE1 ABO ACE1/ACE2 ACE2 ACE2 expression ACE2 gene activate acute respiratory syndrome ADAM17 Adaptive immune response addition Affect Anti-inflammatory approved both sexes cell entry China Chinese contract the virus coronavirus COVID-19 COVID-19 patient death died drugs Epidemic epidemiological data events female females Genes heterozygous Hong Kong hospital human ACE2 receptor immune-related gene IMPROVE individual Infection Inflammation intensive care Interaction involved locus lung shut-down male men mortality rate New coronavirus Other outcome pandemic Prognosis prognostic molecular/genetic markers progression proportions RAS-pathway reducing required responsible resulting role SARS-CoV-2 SARS-CoV-2 disease several gene Sex sex/gender-gap SOX3 Spread SRY subsequent susceptible the SARS-CoV-2 Thromboembolism thrombosis transmembrane serine protease Vaccines WHO women World Health Organization Wuhan, China [DOI] 10.3390/ijms21103474 PMC 바로가기 [Article Type] Hypothesis
The SARS-CoV-2 Exerts a Distinctive Strategy for Interacting with the ACE2 Human ReceptorArticle Published on 2020-04-302022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 binding binding affinity cell receptor comparable complex coronavirus coronavirus evolution country COVID-19 disease death exceptional fluctuation HCoV-NL63 Host Human human ACE2 receptor implication infection rate Interaction interface residue molecular molecular dynamics pathogenic coronavirus protein–protein complex receptor recognize SARS-CoV SARS-CoV-2 Spike protein Strategy the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic strategies virus–host interactions [DOI] 10.3390/v12050497 PMC 바로가기 [Article Type] Article
Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysisOriginal Article Published on 2020-03-182022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] ACE2 affected Analysis binding energy caused change changes in coronavirus determine Epidemic Epidemics event higher affinity host receptor human ACE2 human ACE2 receptor humans in silico in silico Approach Interaction Ligand magnitude outbreak promote receptor reduction in role SARS-CoV-2 SARS-CoV-2 spike protein sequence significant effect spike Spike protein the disease the receptor-binding domain the S1 subunit the SARS-CoV-2 the spike protein Transmission viral disease Viral protein viral spread was performed zoonotic [DOI] 10.17179/excli2020-1167 PMC 바로가기 [Article Type] Original Article