Persistent Systemic Microbial Translocation and Intestinal Damage During Coronavirus Disease-19코로나바이러스 질병-19 동안 지속되는 전신 미생물 이동 및 장 손상Immunology Published on 2021-07-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] acid Admission admitted to ICU age aims alteration AUC bloodstream BSI cell integrity control group COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients damage enrolled evaluated exhibited Fatty acid Gut healthy donor ICU ICU patient ICU Patients IgM in-hospital mortality Infection influence intensive care unit intestinal intestinal damage intestinal damage and permeability intestinal fatty acid binding protein (I-FABP) lipopolysacharide binding protein marker median age microbial translocation microbial translocation in COVID-19 Mortality non-ICU over Patient persistent Predictive SARS-CoV-2 Severe infection severe infections study period subject subsequent systemic translocation with COVID-19 [DOI] 10.3389/fimmu.2021.708149 PMC 바로가기 [Article Type] Immunology
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia뚜렷한 면역학적 특징은 심각한 COVID-19를 SARS-CoV-2에 의해 유발되지 않은 치명적인 폐렴과 구별합니다.Comparative Study Published on 2021-07-132022-09-11 Journal: Immunity [Category] Fulltext, SARS, 바이오마커, 유전자 메커니즘, [키워드] adaptive alteration Analysis binding Biomarker cascade Cell change circulating ClinicalTrials COVID-19 COVID-19 patient Critical Cytometry driven by feature flow cytometry Frequency GM-CSF high-dimensional single cell analysis HLA HLA typing ICU patient ICU Patients immune Immune profile immune profiling immune signature Immunity immunological immunopathology Immunophenotyping Inflammatory response integration interfere longitudinal NKT outcome paralysis Patient peptide peptide binding strength peptides Pneumonia predicted Predictive SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides severe COVID-19 Single Cell single-cell spectral flow cytometry. T cell the patient translation Treatment strategies treatment strategy virus recognition [DOI] 10.1016/j.immuni.2021.05.002 PMC 바로가기 [Article Type] Comparative Study
Endothelial, Immunothrombotic, and Inflammatory Biomarkers in the Risk of Mortality in Critically Ill COVID-19 Patients: The Role of DexamethasoneArticle Published on 2021-07-132022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] administration Admission association AUC Biomarker Biomarkers Coagulation Cohort COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill Dexamethasone dose dysfunction endothelial Endothelial dysfunction exhibited first dose greater ICU ICU admission ICU Patients Ill increasingly Inflammation inflammatory biomarkers intensive care investigated Kaplan–Meier analysis Kaplan–Meier survival analysis Mortality mortality risk non-survivor outcome Patient Presepsin prognostic prognostic biomarker Prognostic marker receiver operating characteristic receptor ROC ROC curves role Serum level single-center study suPAR survival sVCAM-1 the median vascular cell adhesion VCAM-1 was used were measured [DOI] 10.3390/diagnostics11071249 PMC 바로가기 [Article Type] Article
A validation study of UCSD-Mayo risk score in predicting hospital-acquired acute kidney injury in COVID-19 patientsCOVID-19 환자의 병원 획득 급성 신장 손상 예측에서 UCSD-Mayo 위험 점수에 대한 검증 연구Multicenter Study Published on 2021-07-072022-09-10 Journal: Renal failure [Category] SARS, 치료기술, [키워드] Acute kidney injury age AKI Analysis branch C-statistic Clinical outcome Cohort Comorbidities coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients death defined discrimination enrolled evaluated except for Gender ICU ICU patient ICU Patients Intervention Kidney injury lack mechanical ventilation medical records Ninth outcome Patient patients performed poor prognosis proximal tubule R 2 reached Result risk risk factor Risk factors study period subgroup subgroups Tongji Hospital validation study Wuhan [DOI] 10.1080/0886022X.2021.1948429 PMC 바로가기 [Article Type] Multicenter Study
Effect of curcumin-pipeine supplementation on clinical status, mortality rate, oxidative stress, and inflammatory markers in critically ill ICU patients with COVID-19: a structured summary of a study protocol for a randomized controlled trialCOVID-19가 있는 중환자 중환자실 환자의 임상 상태, 사망률, 산화 스트레스 및 염증 지표에 대한 커큐민-피페인 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-07-062022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 addition Administered All participants allocation sequence ALT anticipated Anticoagulant assigned AST baseline Blinding Blood oxygen saturation C-reactive protein Capsule clinical clinical status Clinical symptoms clinical trial clinical trials CLOCK collected color conducted congenital disorders control group coronavirus COVID-19 creatinine Critically ill CRP Curcumin definitive diagnosis Diseases disorders dissemination double-blind drug Effect Efficacy element eligible patient enteral feeding erythrocyte sedimentation erythrocyte sedimentation rate ESR exclusion criteria Factors female Fever File Hepatic insufficiency hospital ICU ICU patient ICU Patients immune include inclusion criteria independent Inflammatory marker intensive care intensive care unit Intervention intervention group investigators Iran kidney function marker kidney function markers labeling LDH liver male maltodextrin marker matching placebo Medical Sciences Mortality mortality rate normalization number Nurses objective odor outcome oxidative stress oxygen Pancreatitis parameter parenteral nutrition participant Participants Patient PCR test performed physician Physicians piperine Placebo placebo group placebo-controlled Primary outcome protocol provided random randomised randomised controlled trial Randomized Randomized controlled trial Randomly receive recruited Registered registration date registration number registry renal respiratory rate Sample size sealed secondary outcome Secondary outcomes sedimentation rate sensitivity sequence Seven Sex shape status Stratification stratified block randomization study participant Study participants Study protocol supplementary material Support Tablet Taste temperature the placebo group title Trial Trial registration turmeric underlying disease underlying diseases university ventilator Version Warfarin website weight [DOI] 10.1186/s13063-021-05372-9 PMC 바로가기 [Article Type] Letter
Systematic Review of Antiphospholipid Antibodies in COVID-19 Patients: Culprits or Bystanders?COVID-19 환자의 항인지질 항체에 대한 체계적인 검토: 범인인가 방관자인가?Article Published on 2021-07-032022-09-12 Journal: Current Rheumatology Reports [Category] SARS, 진단, [키워드] antibody antiphospholipid antibodies cohort study COVID-19 COVID-19 patient COVID-19 patients disease Hypothesis ICU Patients IgA IgG and IgM Lupus lupus anticoagulant Patient positive Prevalence procoagulant ranged recent review suggested thrombosis Thrombotic events Treatment [DOI] 10.1007/s11926-021-01029-3 PMC 바로가기 [Article Type] Article
Association between renin-angiotensin-aldosterone system inhibitor treatment, neutrophil-lymphocyte ratio, D-Dimer and clinical severity of COVID-19 in hospitalized patients: a multicenter, observational studyObservational Study Published on 2021-07-012022-10-05 Journal: Journal of human hypertension [Category] SARS, 임상, 치료법, [키워드] 95% CI 95% confidence interval ACEIs analyzed angiotensin receptor blocker angiotensin-converting enzyme inhibitor ARBs Bayesian posterior Clinical characteristics Clinical outcome Clinical severity correlation COVID-19 D-dimer level death defined demographic Hospitalized hospitalized COVID-19 patients hypertension ICU ICU Patients inhibitor intensive care laboratory parameter males mechanical ventilation median multicenter NIMV NLR Occurrence Other outcome Patient patients PCR polymerase chain predictor Primary outcome Primary outcomes significantly statistical treated Treatment worsening [DOI] 10.1038/s41371-020-00405-3 PMC 바로가기 [Article Type] Observational Study
Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective studyCOVID-19 환자의 중대 질환 다발신경병증, 근육병증 및 신경 바이오마커: 전향적 연구Observational Study Published on 2021-07-012022-09-11 Journal: Clinical neurophysiology : official journal of the [Category] MERS, 바이오마커, 임상, 진단, [키워드] Acidic Adult patients amplitudes Biomarker Characteristics cohort study coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients Critical Critical illness Critical illness neuropathy Critical illness polyneuropathy develop early phase feature GFAp had more ICU ICU care ICU patient ICU Patients intensive care intensive care unit invasive ventilation light chain Myopathy neurofilament neuronal Neuropathy NfL Non-COVID-19 non-COVID-19 cohort Patient plasma biomarker Polyneuropathy Predictive prevalent Prospective Study Protein SARS-CoV-2 significantly higher thromboembolic Thromboembolic event treated Uppsala Uppsala University weakness [DOI] 10.1016/j.clinph.2021.03.016 PMC 바로가기 [Article Type] Observational Study
Lung ultrasound predicts clinical course but not outcome in COVID-19 ICU patients: a retrospective single-center analysis폐 초음파는 임상 과정을 예측하지만 COVID-19 ICU 환자의 결과는 그렇지 않음 : 후 향적 단일 센터 분석Research Article Published on 2021-06-282022-09-01 Journal: BMC Anesthesiology [Category] MERS, SARS, 진단, [키워드] Analysis analyzed baseline Clinical course Clinical deterioration Comorbidity consolidation coronavirus coronavirus disease COVID-19 COVID-19 patient Deterioration evaluate group hypertension ICU ICU admission ICU patient ICU Patients intensive care intensive care unit internal intubation lung Lung ultrasound Lung ultrasound score male median mmHg Most patients Munich no difference obesity outcome Patient patients patients died pleural effusion predict recognize reduced Result retrospective significantly single-center standardized protocol stratified subpleural supplementary material survival Ventilation was performed worsened [DOI] 10.1186/s12871-021-01396-5 PMC 바로가기 [Article Type] Research Article
Acute kidney injury (AKI) in patients with Covid-19 infection is associated with ventilatory management with elevated positive end-expiratory pressure (PEEP)Observational Study Published on 2021-06-252022-10-04 Journal: Journal of Nephrology [Category] MERS, SARS, 임상, [키워드] 95% CI Abstract acute respiratory distress AKI AKI patients Analysis ARDS Clinical course COVID-19 CRRT Diagnostic Criteria elevated expiratory Factor higher risk ICU ICU patient ICU Patients incidence Infection intensive care KDIGO Kidney injury management median medium Mortality mortality rate occurred outcome outcomes Patient patients PEEP positive Positive end-expiratory pressure renal replacement therapy required Result retrospective severity significantly higher supplementary material syndrome ventilatory [DOI] 10.1007/s40620-021-01100-3 PMC 바로가기 [Article Type] Observational Study