Nine Months into the COVID-19 Pandemic: A Longitudinal Study Showing Mental Health and Movement Behaviours Are Impaired in UK StudentsArticle Published on 2021-03-122022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] accounted association change changes in COVID-19 COVID-19 pandemic early stage Impaired indicated longitudinal Mental mental health mental illness Month movement Multiple linear regression pandemic Perceived stress persists physical activity Predictive sedentary behaviour Stress student sustained These data variable was impaired were assessed [DOI] 10.3390/ijerph18062930 PMC 바로가기 [Article Type] Article
Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients점막 관련 불변 T(MAIT) 세포는 COVID-19 환자에서 고도로 활성화되고 기능적으로 손상됩니다Article Published on 2021-02-032022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Antiviral caused Cell cells contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 cytokine cytokine expression profile Cytokines cytolytic disease disease severity Ex vivo Express expression flow cytometry granzyme B HLA-DR IL-17A immune system Immunopathogenesis Impaired in vitro Infection lung marker measure Mild mucosal-associated invariant T (MAIT) cells Organ failure Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 perforin phenotype positively correlated progression Proinflammatory cytokine proinflammatory cytokines Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cells TNFα [DOI] 10.3390/v13020241 PMC 바로가기 [Article Type] Article
Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients중증 COVID-19 환자의 SARS-CoV-2에 대한 세포 면역 손상Immunology Published on 2021-02-022022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] acute infection acute phase acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adaptive immune response Adaptive immunity antibody Antibody Response ARDS CD4 CD8 cellular cellular immunity convalescent individual coronavirus COVID-19 COVID-19 patient develop exhibited expression healthy controls Hospitalization humoral immune responses IFNγ Impaired individual infection rate interferon gamma MOST mounted Neutralization antibody Neutralizing antibodies NK cell pandemic percentage Peripheral blood peripheral blood lymphocyte producing reduced responses SARS-CoV-2 severe COVID-19 patient Severe patient severe patients shown significantly Spread Symptoms syndrome T cell T cells Viral proteins virus [DOI] 10.3389/fimmu.2021.603563 PMC 바로가기 [Article Type] Immunology
A Valid Warning or Clinical Lore: an Evaluation of Safety Outcomes of Remdesivir in Patients with Impaired Renal Function from a Multicenter Matched Cohort유효한 경고 또는 임상 지식: 다기관 일치 코호트에서 손상된 신장 기능이 있는 환자에서 렘데시비르의 안전성 결과 평가Comparative Study Published on 2021-01-202022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] 1:1 absence Acute kidney injury administration AKI applied baseline Chronic kidney disease clearance clinical confounders COVID CrCl creatinine creatinine clearance disease Frequency function Guidance hospitalized patient hospitalized patients Impaired inclusion criteria interquartile range IQR kidney Kidney disease Liver function test liver function tests Matched mechanically ventilated multicenter no significant difference Older outcome Patient patient population primary endpoint Remdesivir renal renal disease renal failure retrospective Safety SARS-CoV-2 SBECD significantly therapy Treatment Vasopressor vasopressors [DOI] 10.1128/AAC.02290-20 PMC 바로가기 [Article Type] Comparative Study
Surviving COVID-19 in Bergamo province: a post-acute outpatient re-evaluationOriginal Paper Published on 2021-01-192022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, [키워드] approach Bergamo clinically complex Consequences coronavirus disease COVID-19 COVID-19 patient D-dimer elevation D-dimer value Diagnosis diffusion discharge discharged Dyspnoea effective Epidemic fatigue Follow-up hospital Impaired long-COVID lung median time pathology Patient post-acute post-traumatic problem Psychological silent Symptoms threshold thrombosis [DOI] 10.1017/S0950268821000145 PMC 바로가기 [Article Type] Original Paper
Predictive Factors for Impaired Mental Health among Medical Students during the Early Stage of the COVID-19 Pandemic in MoroccoArticles Published on 2021-01-172022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, [키워드] alleviate Analysis Anxiety baseline conducted consequence COVID-19 COVID-19 pandemic Depression distress Enrollment Evidence Factor female female gender Generalized Impaired Insomnia Insomnia Severity Index Intervention Logistic regression Long-term follow-up median Mental mental health mental health issues Morocco multivariable logistic regression Odds ratio outcome Physicians Prevalence prevalence of COVID-19 PROTECT Psychiatric psychological condition Psychological distress psychological support Region reported risk factor scale Screening severe symptom Stage student Symptom Symptoms [DOI] 10.4269/ajtmh.20-1302 PMC 바로가기 [Article Type] Articles
SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell ResponseCD8+ T 세포 반응이 손상된 개인에서 87일 이상 동안 SARS-CoV-2 바이러스 RNA 방출Observational Study Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] airway Antibody titer Antibody titers case subject CD4+ T cell CD8+ CD8+ T cell cellular immunity circulating Cohort COVID-19 Day detectable exhibited expected first positive Impaired in some individual individuals with COVID-19 Infection Neutralizing antibody response neutralizing antibody responses occur one individual plasma neutralization activity positive Prolonged Protein Re-infection response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral RNA severe COVID-19 shedding subject subjects symptom onset T cell T cell responses T cells tested upper airway Viral Viral RNA Viral RNA shedding [DOI] 10.3389/fimmu.2020.618402 PMC 바로가기 [Article Type] Observational Study
Determinants of Increased Fibrinogen in COVID-19 Patients With and Without Diabetes and Impaired Fasting Glucose당뇨병이 있거나 없는 COVID-19 환자 및 공복 혈당 장애 환자에서 증가된 피브리노겐의 결정 요인Article Published on 2021-01-012022-09-11 Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 바이오마커, [키워드] analyzed C-reactive protein control group COVID-19 COVID-19 patient COVID-19 patients CRP demographic data determinant diabete diabetes died elevated Factor fasting fasting glucose ferritin ferritin levels fibrinogen Final Glucose glucose metabolism group Hospitalization hypercoagulability IL-6 IL-8 Impaired impaired fasting glucose Increased Inflammation insulin insulin resistance interleukin interleukin-6 involved IQR Laboratory results Linear regression medical history metabolism Multiple Multiple linear regression Necrosis normal range Patient positively correlated R 2 reduce Regulation Serum ferritin significantly increased Signs and symptoms Symptoms TG level TG levels TNF-α Triglyceride triglycerides Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α was impaired [DOI] 10.1177/1076029621996445 PMC 바로가기 [Article Type] Article
Depletion of circulating IgM memory B cells predicts unfavourable outcome in COVID-19순환하는 IgM 기억 B 세포의 고갈은 COVID-19에서 불리한 결과를 예측합니다Article Published on 2020-11-302022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] 95% CI Adaptive immunity age analyses B-cell Cell circulating Comorbidities coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cumulative cumulative incidence rate Depletion died enrolled female females hospitalisation hypothesised IgM immune response immune responses Immunopathogenesis Impaired incidence rate increased mortality Infection infections Infectious diseases internal medicine Italy lymphocyte Lymphocyte count Lymphocytes memory B memory B cell memory B cells not correlated number of comorbidities Older age outcome Patient patients with COVID-19 Peripheral blood predict reduction Sex specimen spleen Trigger two COVID-19 patients were excluded [DOI] 10.1038/s41598-020-77945-8 PMC 바로가기 [Article Type] Article
The role of Interleukin-4 in COVID-19 associated male infertility – A hypothesisReview article Published on 2020-11-012022-10-05 Journal: Journal of reproductive immunology [Category] SARS, 유전자 메커니즘, [키워드] abdominal pain ACE-2 ACE-2 receptor activate activated activating Activation ALT Apoptosis AST attenuate Bilirubin Cancer Chronic kidney disease CNS Comorbidity complex COVID-19 COVID-19 patient COVID-19 patients cytokine decrease deregulating Diabetes Mellitus diarrhea dysfunction Hematuria Hypothesis IgE IgG IL-12 IL-4 IL-6 Impaired Infection Inflammation interferons Interleukin-4 Jak-STAT JAK-STAT pathway JAK-STAT signaling Liver injury Lung injury male male infertility morbidity and mortality ocular pandemic pathway populations pro-inflammatory cytokine risk SARS-CoV-2 Signaling STAT Th2 Th2 cell Th2 cells the patient TNF-α triggering vomiting [DOI] 10.1016/j.jri.2020.103213 [Article Type] Review article