innate immune system – Page 9 – Communicable Diseases Research

NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration

Review

Published on 2021-06-292022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다

Immunology

Published on 2021-06-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load
[DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology

SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages

Immunology

Published on 2021-06-232022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 receptor Activation Anti-inflammatory anti-inflammatory response CD14+ monocytes Cell cell type chemokines COVID-19 COVID-19 patients CXCL5 cytokine Cytokine storm Cytokines death demonstrated Engagement enzyme examined expression had no human macrophage human PBMC IL-6 IL6 IL8 inactive induce infect Inflammation inflammatory mediator Inflammatory response initiate innate immune system Interaction IRAK-M isoform LPS-activated lung Macrophage macrophages magnitude modulate mRNA mRNA expression mRNA levels PBMCs pro-inflammatory pro-inflammatory cytokine Production promoted Protein protein expression protein level receptor regulated SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 S SARS-CoV-2 S protein shown stimulated suppressed therapeutic strategy THP-1 TLR TLR ligand TNFα treated Treatment
[DOI] 10.3389/fimmu.2021.683800 PMC 바로가기 [Article Type] Immunology

Clinical Performance of Paraoxonase-1-Related Variables and Novel Markers of Inflammation in Coronavirus Disease-19. A Machine Learning Approach

Article

Published on 2021-06-212022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

Ramping Up Antimicrobial Peptides Against Severe Acute Respiratory Syndrome Coronavirus-2

Molecular Biosciences

Published on 2021-06-212022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] acute respiratory syndrome adaptive immune responses Against aggregation AMP AMPs antimicrobial antimicrobial peptide antimicrobial peptides (AMPs) binding Candidates Cell chemokine Combination coronavirus coronavirus disease Coronavirus-2 COVID-19 Defense Defensins derivative effective ENhance expressed highlight Host host inflammatory response immunological individuals infected with SARS-CoV-2 innate immune system LL-37 mechanism modulate modulating MSCs pandemic platform Prophylactic public health receptors released respiratory SARS-CoV-2 severely ill patient severity therapeutic therapeutic option therapy treat Treatment variety viral infectivity viral particle viral replication virions viruses Vitamin D3
[DOI] 10.3389/fmolb.2021.620806 PMC 바로가기 [Article Type] Molecular Biosciences

Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19

Cell and Developmental Biology

Published on 2021-06-112022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus
[DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology

Migraine and neuroinflammation: the inflammasome perspective

Review Article

Published on 2021-06-102022-10-29
Journal: The Journal of Headache and Pain [Category] COVID-19, MERS, SARS,

Rintatolimod Induces Antiviral Activities in Human Pancreatic Cancer Cells: Opening for an Anti-COVID-19 Opportunity in Cancer Patients?

Article

Published on 2021-06-092022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] activated activating activity adaptive immune system additional treatment option Anti-viral Antiviral effect block cancer patient cascade cells chemokine cytokine Cytokines death demonstrated epidemiological epithelial epithelial cancerous cells epithelial cells expression fibrosis Gene expression profiling Human independent induce infected with SARS-CoV-2 Infection innate immune system interferon signaling opening opportunity outcome overexpression pancreatic cancer cell pathway patients with COVID-19 Prevent producing proteomics Rintatolimod RNase RNase L SARS-CoV-2 SARS-COV-2 infection severity signaling pathway simple Specific Spread stimulated the disease the interferon TLR3 Toll-like receptor 3 treat Treatment treatment for COVID-19 treatment regimen uninfected USA virus replication was measured
[DOI] 10.3390/cancers13122896 PMC 바로가기 [Article Type] Article

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

SARS-CoV-2 RNA혈증 및 단백질 궤적은 중환자실에 입원한 COVID-19 환자의 예후를 알려줍니다

Article

Published on 2021-06-072022-09-10
Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjusted age and sex Antibody Response antiviral properties best binding blood sample Blood samples cell-cell fusion Characteristics comparable Comparisons complement Complement pathway complement system controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient galectin-3 hazard ratio healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU patient ICU Patients in vitro inhibit innate immune system intensive care intensive care unit interaction partner LGALS3BP machine machine learning mannose mass spectrometry Mortality Neutralizing antibody response Non-COVID-19 overexpression Patient plasma predict predictors Prognostic markers Protein proteomic Ptx3 respiratory risk stratification RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike glycoprotein Sepsis sepsis patient serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein survival trajectory Viral Viral RNA
[DOI] 10.1038/s41467-021-23494-1 PMC 바로가기 [Article Type] Article

The Many Faces of Innate Immunity in SARS-CoV-2 Infection

Review

Published on 2021-06-042022-10-28
Journal: Vaccines [Category] COVID-19,