The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article
A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome매우 특이적인 파지 방어 시스템은 Vibrio cholerae mobilome의 보존된 특징입니다Research Article Published on 2017-06-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerate bacterial cell bacteriophage bacteriophages causative agent cell lysis cholerae chromosomal conserved contributed defend Defense diarrheal diarrheal disease disease cholera element Epidemic Evolution expansion favor feature FIVE Genetic genome replication genomic host cell host cells humans Infection investigated isolate killing Kinetics mechanism microbial community neighboring cell neighboring cells pathogen Patient phage phage genome phage-resistant phages predatory prevalent progeny Protective reduce respond selective spread to Stool strain unique Vibrio cholerae virulent widespread [DOI] 10.1371/journal.pgen.1006838 PMC 바로가기 [Article Type] Research Article
The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase VariationPilin N-말단 도메인은 Pilus 단계 변이 동안 Neisseria gonorrhoeae 변환 능력을 유지합니다Research Article Published on 2016-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Amino acid amino acids Antibiotic resistance antigenic variant antigenic variation Bacteria bacterium can not Cell cleavage cleavage site competence Critical Defense demonstrated DNA domain ELISA ELISAs exhibited fiber foreign DNA form function gene transfer genetic determinant genetic determinants gonococcal gonococcal infection gonorrhea horizontal gene Horizontal gene transfer human pathogen Immune escape Infection isolates killing lead locus maintain mechanism Microscopy morphology Mutagenesis Mutation N-terminal N-terminal domain N-terminus natural transformation Neisseria gonorrhoeae neutrophil nonsense mutation Nonsense mutations nucleotide occur pathogenic phase PilE pili pilin pilus producing Protein purification Recombination recombination event Release released required residue residues responsible retained sexually transmitted infection single nucleotide Spread strain Strains subunit the disease these cell These cells thought transfer transformation transmitted twitching Type Type IV pilus undetectable unique uptake variant while wild-type [DOI] 10.1371/journal.pgen.1006069 PMC 바로가기 [Article Type] Research Article
Comparative Genomic Analysis of Drechmeria coniospora Reveals Core and Specific Genetic Requirements for Fungal Endoparasitism of NematodesDrechmeria coniospora의 비교 게놈 분석을 통해 선충류의 곰팡이 내부 기생충에 대한 핵심 및 특정 유전적 요구 사항이 밝혀졌습니다.Research Article Published on 2016-05-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adhesion Analysis arms race branch Caenorhabditis elegan Caenorhabditis elegans can be used characterisation characterized Comparative core Dissection elegan elegans Endoparasitism Evolution evolutionary arms race expresse expressed fluorescent reporter genes functional fungal Fungal infection fungi fungus Gene Expression Gene expression analysis gene families gene family Genes Genetic genetic engineering genetic transformation Genome genomic growth Host in silico infect Infection initial Interaction Interference involved kill killing knock-out knowledge lifecycle mechanism Modification molecular mycelia nematode nematodes NETs opens parasitic nematodes parasitism pathogen pathogen’ Phylogenetic analysis probe regulated reported reporter genes Requirement sequenced Specific spore Stage Tolypocladium transformation TRAP virulence [DOI] 10.1371/journal.pgen.1006017 PMC 바로가기 [Article Type] Research Article
Alveolar macrophages in pulmonary host defence – the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing폐 호스트 방어에서의 알베올라 매크로페이지 - 세포 내 세균 사멸 메커니즘으로서의 아포토시스의 인식되지 않은 역할journal-article Published on 2013-10-062024-08-04 Journal: Clinical and Experimental Immunology [Category] 폐렴구균 감염증, [키워드] Bacteria killing Macrophage Streptococcus pneumoniae [DOI] 10.1111/cei.12170 [Article Type] journal-article
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape MutantsResearch Article Published on 2006-07-042022-10-29 Journal: PLoS Medicine [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Administered affected against SARS-CoV Alter Amino acid anti-SARS-CoV antibody antibody antibody concentration Antigen antigens approach arising Bacteria binding blocked Blood breadth carried caused center China close contact close person-to-person contact Combination complementary Concentration Control convalescent SARS patient coronavirus Coverage CR3014 CR3022 died different disease disease severity dose Effect effective Epidemic Epidemics epitope escape experiment feasible ferret ferrets finding generate glycoprotein Guangdong Health healthy Hong Kong Human human cell human cells human macrophage Human monoclonal antibody humans immune Immune escape immunization immunize in vitro individual effects Infected infecting Infection infectious Infectious disease information interact Interaction International killing Laboratory less limit lung damage Lung pathology mAb mAbs measure monoclonal monoclonal antibody Mutation neutralization neutralized NO organism Patient pharyngeal Prevent prevented prevention producing Prophylaxis provided quarantine recognize recognizing reduce reduction repeated replicated required Research researcher residue responsible SARS epidemic SARS-CoV SARS-CoV infection screened shown sick Spread strain suppress synergistic synergistic fashion synergy tested the disease the receptor-binding domain Travel treat variant variants viral escape viral spread virus Virus neutralization virus strain virus-neutralizing viruses website Wikipedia World Health Organization [DOI] 10.1371/journal.pmed.0030237 PMC 바로가기 [Article Type] Research Article