Mapping the SARS-CoV-2–Host Protein–Protein Interactome by Affinity Purification Mass Spectrometry and Proximity-Dependent Biotin Labeling: A Rational and Straightforward Route to Discover Host-Directed Anti-SARS-CoV-2 TherapeuticsSARS-CoV-2–숙주 단백질–단백질 상호작용체 매핑(Affinity Purification Mass Spectrometry 및 Proximity-Dependent Biotin Labeling: Host-Directed Anti-SARS-CoV-2 치료제 발견을 위한 합리적이고 간단한 경로)Review Published on 2021-01-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advent affinity Affinity purification affinity-purification mass spectrometry Antiviral approach approved drug cellular cellular processe cellular processes coronavirus coronavirus disease COVID-19 Drug discovery Drug repurposing effective emerging experiment Follow-up Generation help high resolution Host host cell host cells host protein identify Interaction interactome life cycle mapping mass mass spectrometry mirage offer outbreak PPI protein interactions protein–protein interactions protein–protein interaction proteomics proximity-dependent biotin labeling (BioID) reduce regulated respiratory route SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spectrometry target targets therapeutic option therapeutic targets Therapeutics Viral viral life cycle virus virus entry virus–host interaction virus–host interactions [DOI] 10.3390/ijms22020532 PMC 바로가기 [Article Type] Review
Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run단일 실행에서 100개 항체의 항체 결합 에피토프 매핑(AbMap)Article Published on 2021-01-012022-09-12 Journal: Molecular & Cellular Proteomics : MCP [Category] 진단, [키워드] antibody binding binding epitope conformational convalescent serum COVID-19 COVID-19 patient defined diagnostics epitope epitope mapping functional information less linear linear epitope magnitude mapping Next-generation sequencing peptide phage display profile PROTECT random random peptide library. specific antibody Spike protein the antibodies [DOI] 10.1074/mcp.RA120.002314 PMC 바로가기 [Article Type] Article
CO1 Mapping The Landscape Of Covid-19 Clinical Trials In The US: Assessing The Opportunities And Gaps In Trial Designs, Interventions And EndpointsConference abstract Published on 2020-12-012022-10-05 Journal: Value in health : the journal of the International [Category] 임상, [키워드] Assessing clinical Gap landscape mapping opportunity [DOI] 10.1016/j.jval.2020.08.016 [Article Type] Conference abstract
Searching for COVID-19 Antibodies in Czech Children—A Needle in the HaystackPediatrics Published on 2020-11-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] acute respiratory syndrome age antibodies antibody Antibody Response Asymptomatic caused children coronavirus COVID-19 Czech Republic Frequency help hospital infected children mapping Mild symptom needle Pandemics pediatric Prague Prevalence Protective SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 seroprevalence screened seropositive subject Seroprevalence shown tested the disease the SARS-CoV-2 Therapeutic strategies virus zero [DOI] 10.3389/fped.2020.597736 PMC 바로가기 [Article Type] Pediatrics
Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasterideArticle Published on 2020-10-272022-10-04 Journal: Nature Communications [Category] 변종, 신약개발, [키워드] accompanied Analysis binding catalyzed clinically conformational Critical cytosolic deficiency Dihydrotestosterone disease-causing mutation drug drugs targeting Effects enzyme Enzyme mechanisms eukaryotic facilitate Finasteride Human information inhibitors lack mapping mechanism membrane metabolic pathways metabolism molecular dynamics molecular mechanism Mutagenesis NADPH offer Prostate Prostate cancer Reductase reduction regulate residue SRD5A2 Steroid hormones Structure Topology transmembrane domain unique X-ray crystallography [DOI] 10.1038/s41467-020-19249-z PMC 바로가기 [Article Type] Article
Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope MappingResearch Article Published on 2020-10-172022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] 3D structure acute respiratory syndrome administration antibody Antibody binding approved drugs caused chicken clinician coronavirus COVID-19 cross-reactive enzyme epitope epitope mapping Epitopes exhibited feasibility FIVE Generation global pandemic Health immune responses immunization Immunoglobulin immunoreactivity include intranasal linear epitope Local mapping neutralizing antibody overlap physically Protein proteolytic proteolytic cleavage raised repurposing respiratory infections risk S trimer S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV S SARS-CoV-2 SARS-CoV-2 S scientist spike subsequent Therapeutic approach therapy treating SARS-CoV-2 infection Vaccine viral cell virus-cell membrane fusion [DOI] 10.1155/2020/9465398 PMC 바로가기 [Article Type] Research Article
Mapping Evidence of Pharmacy Services for COVID-19 in ChinaPharmacology Published on 2020-10-022022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Analysis article articles case sery changes in China Chinese collected data Consensus COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 patient criteria database disease emergency supply evidence of guideline development identify implementation Infection Infrastructure Intervention limit literature review majority mapping Medicine objective pandemic Patient Pharmacist Pharmacy pharmacy service Prevent restrict Result searched service service model innovation spread of COVID-19 Symptom treat Treatment treatment regimen treatment regimens website [DOI] 10.3389/fphar.2020.555753 PMC 바로가기 [Article Type] Pharmacology
A Systematic, Unbiased Mapping of CD8 + and CD4 + T Cell Epitopes in Yellow Fever VaccineesImmunology Published on 2020-08-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] Analysis approach binding blood sample CD4 CD4+ and CD8+ T cell epitope discovery CD8 Cohort Combination confounding effect convalescent Coverage demonstrated diagnostic epitope Evidence Ex vivo Examining false discovery rate flanking regions forward-reverse immunology HLA HLA class I HLA haplotype humans identify immunodominance and immunodomination immunodominant immunogenicity include information isotypes magnitude mapping overlapping pathogen patients peptide peptide epitopes peptide-MHC predictors peptide-MHC tetramers predictor prevalent protein antigen proteome reduce representing required response responses Restricted risk SARS-CoV-2 specificity staining Support Survivors T cell T cell epitope T cell epitopes T cell response T cell responses therapeutic vaccination virus volunteers yellow yellow fever vaccination [DOI] 10.3389/fimmu.2020.01836 PMC 바로가기 [Article Type] Immunology
Mapping the situation of research on coronavirus disease-19 (COVID-19): a preliminary bibliometric analysis during the early stage of the outbreakResearch Article Published on 2020-08-012022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, [키워드] 2019-nCoV analysed Analysis applied Bibliometric Care China clinical feature Community coronavirus disease Coronavirus disease-19 country COVID-19 COVID-19 research database determine early stage feature Harvard Medical School Health highlight include indicated Infection infection control Italy journal mapping Neonatal Novel coronavirus outbreak outcomes pathological finding performed presenting prevalent reported Research Result Science Scopus Spread technology therapeutic university USA [DOI] 10.1186/s12879-020-05293-z PMC 바로가기 [Article Type] Research Article
A Comprehensive Mapping of the Druggable Cavities within the SARS-CoV-2 Therapeutically Relevant Proteins by Combining Pocket and Docking Searches as Implemented in Pockets 2.0Article Published on 2020-07-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis approach binding binding pocket blind docking Cavity Combination Comprehensive coronavirus 2 docking docking simulations in silico mapping performed pocket pocket druggability pocket search Protein reached recognize SARS-CoV-2 SARS-CoV-2 protein targets the SARS-CoV-2 Virtual screening [DOI] 10.3390/ijms21145152 PMC 바로가기 [Article Type] Article