Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality controlReview Published on 2020-06-082022-10-31 Journal: Electrophoresis [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adjuvants approach approval average buffer centrifugation competent condition conditions coronavirus COVID‐19 downstream Effects epitope example feasible Formulation immunologically inactivation information knowledge membranes Physicochemical properties Protein Quality control Radiation rigidity SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV solvent stability Support susceptibility temperature transfer UV light Vaccine Vaccine development virus virus inactivation [DOI] 10.1002/elps.202000121 PMC 바로가기 [Article Type] Review
Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis임신 중 코로나바이러스 스펙트럼 감염(SARS, MERS, COVID-19) 결과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2020-05-012022-09-11 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 변종, [키워드] 95% confidence interval accumulating acute respiratory syndrome Admission affected APGAR score asphyxia caution CINAHL clinical evidence Clinical sign Clinical signs Combination combinations confidence interval coronavirus Coronavirus 2019 Coronavirus infections cough counseling COVID-19 COVID-19 infection criteria database death defined Diagnosis disease distress during pregnancy Dyspnea eligibility eligible English language ENhance Evidence evidence of fetal fetal distress Fever growth Hospitalized inclusion criteria Infection infections intensive care membrane membranes MERS Meta-analysis Middle East Middle East respiratory syndrome miscarriage mode mother Neonatal neonatal asphyxia neonatal intensive care unit Newborn occurred outcome Perinatal death Pneumonia preeclampsia pregnancies Pregnancy pregnant women Premature prenatal Preterm birth proportion proportions reported respiratory rupture rupture of membranes searched Severe acute respiratory syndrome severe acute respiratory syndrome–coronavirus-2. Symptom syndrome systematic review These data Transmission variant vertical transmission with COVID-19 women [DOI] 10.1016/j.ajogmf.2020.100107 PMC 바로가기 [Article Type] Meta-Analysis
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entryResearch Article Published on 2020-03-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, SARS, [키워드] addition Affect analyses binding biochemical cell entry change changes in conformational change coronavirus coronavirus spike protein cryo-EM structure domain Entry mechanism facilitate facilitated feature Hepatitis highlight Host host cell host cells host membranes in viral induce Interaction mechanism membranes MHV molecular mechanism mouse N-terminal domain NTD performed pre-fusion promote protease Protein provide question receptor Receptor binding recognize Research reveal S1 and S2 sensitivity Spike protein spike trimer Structure Treatment trimeric trimeric spike unique variety viral entry viruses while [DOI] 10.1371/journal.ppat.1008392 PMC 바로가기 [Article Type] Research Article
The Porcine Deltacoronavirus Replication Organelle Comprises Double-Membrane Vesicles and Zippered Endoplasmic Reticulum with Double-Membrane SpherulesArticle Published on 2019-11-052022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] addition Beta cell interaction cellular membrane characterized coronavirus country Culture diarrhea DMV double-membrane spherule Double-membrane vesicle Endoplasmic reticulum Hong Kong induce infected cell Infectious Bronchitis Virus Initially membrane membranes Microscopy organelle other coronavirus Porcine deltacoronavirus progeny protein synthesis question Region Replication Replication organelle Reticulum RNA virus spherule spherules strain Structure Support tissue USA Vesicle vesicles viral RNA synthesis virus virus replication were assessed zippered ER [DOI] 10.3390/v11111030 PMC 바로가기 [Article Type] Article
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell deathArticle Published on 2018-09-052022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, MERS, [키워드] activate addition Apoptotic cell death autophagy caspase-1 cause clinical manifestation contributing to dysfunction Effect Factor Genes helping implicated interact lysosomal lysosomal membrane membranes molecular mechanism necrotic cell death NLRP3 inflammasome assembly nucleus occur oligomerization Open reading frame pathophysiologic pathway Pathways Potassium Protein reading SARS-CoV SARS-CoV infection severe lung pathology target TFEB Transcription translocate Trigger while [DOI] 10.1038/s41419-018-0917-y PMC 바로가기 [Article Type] Article
Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA ReplicationResearch Article Published on 2017-11-212022-10-29 Journal: mBio [Category] Coronavirus, [키워드] acute respiratory syndrome Affect biogenesis cleavage coexpressed convoluted membranes coronavirus Coronaviruses cytoplasmic electron tomography element Endoplasmic reticulum eukaryote Evidence expressed Formation highlight Human in viral induce lethal infection maturation membrane structure membranes MERS-CoV Middle East MIMIC Mutagenesis nidovirus nidoviruses nonstructural protein nonstructural proteins Nsp3 nsp4 organelle pathogen Pathogens polyprotein positive precursor proliferation Protein proteolytic Replication replication complex replication organelle biogenesis replication structures required Research respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus SARS-CoV similarity subunit suggested thought transmembrane transmembrane domains transmembrane protein Vesicle viral double-stranded RNA viral factory Viral protein [DOI] 10.1128/mBio.01658-17 PMC 바로가기 [Article Type] Research Article
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis2단계 수송 경로를 통해 모세포가 Bacillus subtilis에서 발달 중인 포자를 양육할 수 있습니다.Research Article Published on 2017-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accumulation Bacillus anthracis Bacillus subtilis Bacteria Bacterial Cell Clostridium difficile complex Concentration conserved Culture culture medium dehydration desiccation dipicolinic acid displace dormancy dormant dry weight engulfment enzyme Enzymes Evidence Express Factor forespore hallmark hallmarks homolog homologs idea late stage mechanism medium membrane membranes molecular basis Morphological mother mother cell Mutagenesis non-pathogenic bacteria nucleoside pathogenic pathway predicted produced Protective Protein pyridine-2,6-dicarboxylic acid remained required residue residues small molecule spore spore core spores sporulation Support translocated Transport vegetative growth water [DOI] 10.1371/journal.pgen.1007015 PMC 바로가기 [Article Type] Research Article
SARS-CoV fusion peptides induce membrane surface ordering and curvatureArticle Published on 2016-11-282022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] acute respiratory syndrome anionic changes in coronavirus CoV domain ESR fusion peptide generate helping Hypothesis induce information interactions involved kinetic mechanism membrane membrane fusion membranes molecular overcome peptide phospholipid promoted reduce S2 subunit SARS-CoV spike glycoprotein Stage Support triggered Vesicle virus entry [DOI] 10.1038/srep37131 PMC 바로가기 [Article Type] Article
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusResearch Article Published on 2014-05-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] accompanied accumulating antiviral activity antiviral drug antiviral intervention cellular membrane complex component Compound concerning conserved Coronaviral coronavirus coronavirus 229E Coronavirus infection Coronavirus replication Coronaviruses Culture early phase epithelia genome replication hallmark highly pathogenic Host host cell cytoplasm implicated Including infections inhibit inhibition inhibitor knowledge membrane membrane vesicle membrane-bound membranes MERS-CoV MERS–CoV Middle East mutant Mutation non-structural protein not affected positive potent raise recruitment reduced replicate Replication representing respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus RNA viruses SARS-CoV screened Substitution synthesis target targeting Transcription Treatment viral life cycle viral replication viral RNA synthesis virus virus entry zoonotic [DOI] 10.1371/journal.ppat.1004166 PMC 바로가기 [Article Type] Research Article
MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatmentStandard Published on 2013-08-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome Alpha Antiviral compound antiviral genes Cell culture cell lines cellular Characteristics characterized consequence CoV CoVs cyclosporin A cytotoxicity develop disease electron microscopy expression found highlight Human humans identify IFN-α implicated implication in vitro induce Infected Infection infectious inhibit inhibited inhibitor innate immune response Interaction interferon Interferon-α membrane membranes MERS-CoV MERS-CoV infection MERS-CoV-infected patients Middle East nuclear translocation observation outbreak outcome phosphorylated Prevent progeny related Replication respiratory RNA synthesis SARS-CoV Stat1 titre Treatment Vero Cell Vesicle viral RNA synthesis was used were used zoonotic CoV [DOI] 10.1099/vir.0.052910-0 PMC 바로가기 [Article Type] Standard