Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessmentResearch article Published on 2022-08-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, [키워드] adenoviral vector Adenovirus administration Antigen approved assessment benefit Benefit/Risk booster capillary leak syndrome cell line Cellular immune response ChAdOx1 circumvent clinical evaluation clinical trial collaboration conducted COVID-19 COVID-19 vaccination Deletion dose effective Emergency use authorization evaluate evaluated expressing Extensive feature fevers Genetic Guillain-barrè syndrome Hemorrhagic HIV humoral immune response Immune thrombocytopenia impair Influenza key consideration malaria manuscript MERS-CoV New Nipah virus Oxford-AstraZeneca platform pre-existing immunity Prophylactic Prostate cancer Replication reported risk Safety SARS-CoV-2 Serious Adverse Event serotype surveillance data syndrome therapeutic thrombosis Tuberculosis University of Oxford Vaccine Vaccine development Vaccines vectored vaccine virus Zika [DOI] 10.1016/j.vaccine.2022.06.008 [Article Type] Research article
Exploring inactivation of SARS-CoV-2, MERS-CoV, Ebola, Lassa, and Nipah viruses on N95 and KN95 respirator material using photoactivated methylene blue to enable reuse재사용을 가능하게 하는 광활성화 메틸렌 블루를 사용하여 N95 및 KN95 호흡기 물질에 대한 SARS-CoV-2, MERS-CoV, 에볼라, 라사 및 니파 바이러스 비활성화 탐색Article Published on 2022-08-012022-09-11 Journal: American journal of infection control [Category] SARS, 변종, [키워드] applied benefit blood plasma cause COVID-19 COVID-19 pandemic decontamination demonstrated Ebola Ebola virus Efficiency equipment examined Health Organization hemorrhagic fever Hemorrhagic fever virus inactivated inactivation MERS-CoV Methylene Methylene blue Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus N95 respirator N95 respirators Nipah virus Outbreaks Pathogens Photochemical inactivation. PPE PROTECT Respirator respirators respiratory syndrome coronavirus reuse SARS-CoV-2 Supply shortages tested variants of SARS-CoV-2 virus virus inactivation World Health Organization [DOI] 10.1016/j.ajic.2022.02.016 PMC 바로가기 [Article Type] Article
Beta interferons from the extant camelids: Unique among eutherian mammals현존하는 낙타과의 베타 인터페론: eutherian 포유류 중 유일Article Published on 2022-08-012022-09-11 Journal: Developmental and comparative immunology [Category] 유전자 메커니즘, 조류인플루엔자, 치료제, [키워드] Antiviral antiviral response Beta camelid Cell cells coronavirus COVID-19 pandemic cysteine cysteines Cytopathic effect cytopathic effects Defense Dromedary Dromedary camel Endemic event expressed expression Host immune response IFN-β immune mechanism induction Infection interferon interferons invading pathogen invading pathogens kidney mammal mammals MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus molecular offer Outbreaks pandemic pathogen Pathogens poly(I:C) poxvirus Protein recombinant IFN-β respiratory syndrome coronavirus RNA virus Treatment unique virus zoonosis zoonotic zoonotic infections [DOI] 10.1016/j.dci.2022.104443 PMC 바로가기 [Article Type] Article
Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19Review article Published on 2022-08-012022-10-05 Journal: Trends in Biotechnology [Category] SARS, 변종, 신약개발, 진단, 치료기술, [키워드] approach aptamer cause COVID-19 Diagnosis diagnostics global mortality HIV immunoassay inefficient influenza viruses MERS-CoV Middle East neutralizing antibody novel Pandemics respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 variants SELEX Therapeutics Treatment variant Viral diseases virus [DOI] 10.1016/j.tibtech.2022.07.012 [Article Type] Review article
Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies신종 코로나바이러스에 대해 일반적으로 처방되는 항우울제의 강력한 항바이러스 활성: 시험관 내 및 실리코 약물 용도 변경 연구Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] activities activity amitriptyline anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Anti-viral antidepressant antidepressants antiviral activity clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Depression disorder disorders drug eating disorders effective Efficacy eight evaluated FDA-approved drug FDA-approved drugs FIVE imipramine in silico in vitro in vivo M pro MERS MERS-CoV migraine molecular docking studies Molecular docking study neuralgia pandemic Paroxetine Patient performed Prophylaxis protease reported symptom Result SARS-CoV-2 sertraline suggested symptomatic and asymptomatic symptoms of depression treating COVID-19 Treatment [DOI] 10.1038/s41598-022-17082-6 PMC 바로가기 [Article Type] Article
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs Research Published on 2022-07-252022-10-05 Journal: Nature Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome AP1G1 ATP8B1 Caco-2 Calu-3 Cell cells conducted coronavirus CRISPR Factor Factors genome-wide CRISPR screen HCoV-229E HCoV-NL63 highlighting Host human cell lines inhibitors lung cell MERS-CoV Meta-analysis Middle East modulate mucins performed plasma membrane Replication respiratory syndrome coronavirus SARS-CoV-2 SARS-CoV-2 replication specificity target therapeutic interventions TMPRSS2 viral entry [DOI] 10.1038/s41588-022-01110-2 [Article Type] Research
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibodySpike S2 도메인 특이적 인간 중화 단일클론 항체의 직접적인 호흡기 투여에 의해 매개되는 강력한 보편적인 베타-코로나바이러스 치료 활성Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta acute respiratory syndrome acute respiratory syndrome coronavirus-2 Administered administration antibody Beta beta-coronavirus check conserved convalescent coronavirus coronavirus vaccine Delta demonstrated determine dose Epsilon Gamma hACE2 hamster hamsters Human human monoclonal antibodies Human monoclonal antibody IgG Immune escape in vivo infected with SARS-CoV-2 Infection infection with SARS-CoV-2 intranasal K18 Lineage mAb mAbs MERS-CoV mice monoclonal antibody Mortality Mutation neutralize SARS-CoV neutralized Neutralizing omicron plasma potent pre-fusion Prevent Prophylactic Recognition recognize reduced respiratory respiratory viral S1 and S2 S2 domain SARS-CoV Urbani SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 spike screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 significantly spike subject subjects tested therapeutic activity therapeutic potential Vaccine variants of concern Viral virus weight loss β-coronavirus [DOI] 10.1371/journal.ppat.1010691 PMC 바로가기 [Article Type] Article
Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccineMVA-MERS-S 백신으로 후기 3차 면역 후 MERS-CoV-스파이크 특이적 B 세포 및 항체의 지속성Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] MERS, 임상, 진단, [키워드] Administered antibody antibody isotypes B cell B cell response B cells binding boost booster booster vaccination caused coronavirus Coronavirus 2019 COVID-19 Cytometry ELISA ELISPOT ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunospot flow cytometry Frequency highlight homologous IgG IgG ELISpot IgG subclasses IgG1 immune immune persistence immune response immune responses Immunity immunization Immunoglobulin ImmunoSpot increase isotypes late booster vaccination long-term immunity longitudinal analysis memory B memory B cells MERS MERS coronavirus MERS-CoV MERS-S Middle East Middle East respiratory syndrome modified vaccinia virus MVA-MERS-S neutralization capacity neutralization test Neutralizing Neutralizing antibodies neutralizing antibody persistence Phase 1 phase 1 trial plaque-reduction neutralization test PRNT50 Protein respiratory Respiratory disease significantly Spike protein syndrome T and B cell responses T cell T cell responses Vaccination strategies Vaccine Viral Viral vector vaccine [DOI] 10.1016/j.xcrm.2022.100685 PMC 바로가기 [Article Type] Article
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome Research Published on 2022-07-192022-10-05 Journal: Nature Communications [Category] 바이오마커, 임상, [키워드] antibody Antibody titer baseline binding booster vaccination clinical trial conducted coronavirus epitope Epitopes evaluate exploratory expressing homologous humoral responses identify IgG immunization immunogenic Increased magnitude MERS-CoV Middle East neutralization Neutralizing pandemic participant Phase 1 RBD respiratory syndrome coronavirus responses S2 subunit Safe spike glycoprotein Support syndrome the receptor-binding domain trial participant trials two-dose regimen vaccination vaccine candidate [DOI] 10.1038/s41467-022-31557-0 [Article Type] Research
Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 AntigenSARS-CoV-2 스파이크 S1 항원의 초민감 면역 감지를 위한 그래핀 기반 전계 효과 트랜지스터Article Published on 2022-07-182022-09-11 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition AFM antibody Antigen buffer carbodiimide caused conducted coronavirus disease COVID-19 Device diagnosis of SARS-CoV-2 disease electrical electron ELISA enzyme enzyme-linked immunosorbent assays evaluated field-effect transistor force Fourier-transform infrared spectroscopy Graphene Health house Infectious disease infrared infrared spectroscopy Interaction limit of detection management MERS MERS-CoV MERS-CoV antigen Optical Microscopy Photoelectron Raman spectroscopy real time reduction SARS-CoV-2 SARS-CoV-2 Spike S1 antigen SARS-CoV-2 virus scanning scanning electron microscopy SEM Spectroscopy spike stability tested the SARS-CoV-2 virus traceability transistor Treatment ultraviolet viral spread X-ray [DOI] 10.1021/acsabm.2c00503 PMC 바로가기 [Article Type] Article