The Coronavirus Network Explorer: mining a large-scale knowledge graph for effects of SARS-CoV-2 on host cell functionSoftware Published on 2021-05-032022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] Activation approach approaches Biological functions clinical observations clinical trial co-morbidity COVID-19 COVID-19 pathogenesis curated Diseases driven by drug Drug repurposing drug target drugs drugs targeting Effect Endpoint experimental evidence functional functions gene expression signature Host host cell host gene human host hypothese identify immunological Interaction interfere knowledge Knowledge graph modulated network network biology observation offer pathway potential mechanism Protein Proteins Result SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 viral supplementary material Virological [DOI] 10.1186/s12859-021-04148-x PMC 바로가기 [Article Type] Software
Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cellsSARS-CoV-2에 감염된 환자의 폐 세포에서 조절되지 않는 비타민 D 내분비계의 증거Article Published on 2021-04-212022-09-10 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] affected Analysis applied BALF BALF cell BALF cells Bronchoalveolar lavage fluid Cell cell cycle cells computational approach Computational approaches conserved CYP27A1 cytokine signaling dataset differentially expressed differentially expressed gene Differentially expressed genes downregulated dysregulated eight elements Endocrine endocrine system Evidence evidence of Gene Expression Genes healthy individuals immune system indirect mechanism infected cells infected with SARS-CoV-2 Infection Interaction Level lung cell lung cells modulated motif NF-κB pathway Patient patients predicted provided receptor reduced Regulation retinoid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Signaling status the cells transcriptomic transcriptomics Vitamin D vitamin D endocrine system Vitamin D receptor [DOI] 10.1038/s41598-021-87703-z PMC 바로가기 [Article Type] Article
Na + /K + -ATPase as a Target of Cardiac Glycosides for the Treatment of SARS-CoV-2 InfectionPharmacology Published on 2021-04-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Activation acute respiratory syndrome Anti-inflammatory Anti-viral antiviral activity Antiviral effect appear cardiac cardiac glycosides cardiac insufficiency cause Cell Chloroquine Compound Concentration coronavirus coronavirus disease COVID-19 dependent on Effect effective Epidemic glycoside Glycosides Hydroxychloroquine impair inflammatory cytokine production influenza A interfere K+ ATPase Lopinavir-ritonavir modulated modulating modulation molecular target morbidity Mortality Na+ NFκB non-enveloped virus pandemic parainfluenza pathology Patient regulated regulatory agencies Remdesivir respiratory viruses rhinovirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection Secondary Metabolite shown Signaling signaling factor signaling pathways target tested transcription factor Transport treat Treatment tyrosine viral infection virus viruses Wuhan, China [DOI] 10.3389/fphar.2021.624704 PMC 바로가기 [Article Type] Pharmacology
Community Risk Factors in the COVID-19 Incidence and Mortality in Catalonia (Spain). A Population-Based StudyArticle Published on 2021-04-042022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] agri-food industry Air pollutants aligned approach association baseline Cancer cardiovascular diseases Comorbidity Concentration covariate covariates COVID-19 COVID-19 incidence develop distribution Factor feature general health status heterogenous highlighting hypothese independent land use and land cover data modulated modulating Mortality outcome pandemic predictors psychological disorders Region Research risk factor Spain variable [DOI] 10.3390/ijerph18073768 PMC 바로가기 [Article Type] Article
Epigenetic Lens to Visualize the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection in COVID-19 PandemicGenetics Published on 2021-03-222022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] Alter alteration assist association chromatin coronavirus Coronaviruses COVID COVID-19 deaths develop DNA Epidemics Epigenetic epigenetic modulation epigenetics evade Factor Genetic global infection highlight Host host cell host gene expression Host immune response host-pathogen interaction human populations immune response immune sensing Immunopathogenesis Infection interactions interfere intrinsic involved kill knowledge Len mechanism MERS-CoV Methylation miRNA Modification modulate modulated Mortality Non-coding RNAs pandemic Pathogenesis pathway phenotypic prevent disease progression provide regulate Replication researchers respiratory respiratory RNA viruses RNA virus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARSCoV2 SARSCoV2 pathogenesis Spread the disease treat Treatment Variation virus widespread [DOI] 10.3389/fgene.2021.581726 PMC 바로가기 [Article Type] Genetics
Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome소화기 및 호흡기관 Ace2 발현의 다양성은 미생물군집과 관련이 있습니다.Research Article Published on 2021-03-162022-08-13 Journal: PLoS ONE [Category] 유전자 메커니즘, [키워드] (coronavirus disease 2019 ACE2 expression angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antibiotics coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection digestive disease severity enzyme exhibiting expressed expression expression level gastrointestinal and respiratory tracts Gastrointestinal symptom gastrointestinal symptoms gene encoding gnotobiotic Gut host protein Hypothesis infection risk intestinal mice Microbiome microbiota modulated Patient peptidases phenotype protease Proteases quantitative PCR raised reducing Regulation reported respiratory respiratory tract risk SARS-CoV-2 spike protein SARS-CoV-2 spike proteins severity of COVID-19 significantly higher specific pathogen-free Spike proteins target These data Variability worse prognosis [DOI] 10.1371/journal.pone.0248730 PMC 바로가기 [Article Type] Research Article
Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker’s yeast: SARS-CoV-2 as a case study빵 효모에서 바이러스 검출을 위한 G 단백질 결합 수용체 및 효모 표면 디스플레이 전략 탐색: 사례 연구로서의 SARS-CoV-2Review Published on 2021-03-042022-09-11 Journal: FEMS yeast research [Category] SARS, 진단, 치료기술, [키워드] ACE2 activated angiotensin Angiotensin-converting enzyme antibody biosensor case study cell receptor complex complexity components Concentration coronavirus COVID-19 Diagnosis diagnosis of COVID-19 diagnostics display effective enrolled enzyme example G protein G protein-coupled receptor G protein-coupled receptors Healthcare system Healthcare systems highly pathogenic Infection Interaction methodology microorganism modulated physical platform receptors Saccharomyces cerevisiae SARS-CoV-2 surface Synthetic biology Treatment Viral Viral detection viral disease Viral diseases viral infections viral titer virus detection viruses while yeast yeast surface display. [DOI] 10.1093/femsyr/foab004 PMC 바로가기 [Article Type] Review
Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapyQingfei Paidu 달인에 의한 약물 대사 효소 억제: COVID-19 약물 요법에서 허브-약물 상호 작용의 의미Article Published on 2021-03-012022-08-31 Journal: Food and chemical toxicology : an international jo [Category] SARS, 치료제, [키워드] AUC caused China Chinese clinical settings clinically clinician combating Combination concomitant use Corona COVID-19 COVID-19 treatment CYP3A substrate-drugs cytochrome P450 Cytochrome P450 enzymes Cytochrome P450 enzymes (CYPs/P450s) demonstrated Effect enzyme half-life Health Herb Herb-drug interactions (HDIs) in vivo inactivated inhibited inhibition inhibitory Interaction interactions Lopinavir medication modulated NADPH P450s pharmacokinetic pharmacokinetics Qingfei Paidu decoction (QPD). RATs risk significantly Spread the patient Treatment Trigger Virus Disease [DOI] 10.1016/j.fct.2021.111998 PMC 바로가기 [Article Type] Article
The basic reproduction number can be accurately estimated within 14 days after societal lockdown: The early stage of the COVID-19 epidemic in DenmarkResearch Article Published on 2021-02-162022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] 95% prediction interval Algorithm annealing basic reproduction number COVID-19 epidemic cumulative death Denmark determine disease spread early stage Epidemic imperative intensive care lockdown Model modulated objective parameter Patient patients provide Result SEIR vital dynamics [DOI] 10.1371/journal.pone.0247021 PMC 바로가기 [Article Type] Research Article
High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiomeResearch Article Published on 2021-02-112022-10-28 Journal: BMC Medicine [Category] Coronavirus, MERS, [키워드] association Bacterial basophil basophils benefit Cardiometabolic risk chronic chronic inflammation correlated covariate COVID-19 diet disease eosinophils false discovery rate Fatty liver Glucose Gut gut microbiome gut microbiome composition healthy individual IL6 Inflammation Inflammatory Inflammatory marker investigated lymphocyte Lymphocyte count lymphocyte counts Lymphocytes marker Mediation analysis Microbiome modulated monocyte multiple testing Neutrophils nutritional intervention processed Result risk RNA Sequencing severe infections significantly supplementary material Variation vegetable intake White blood cell White blood cells [DOI] 10.1186/s12916-021-01913-w PMC 바로가기 [Article Type] Research Article