monotherapy – Page 9 – Communicable Diseases Research

Drug-utilisation profiles and COVID-19

Article

Published on 2021-04-262022-10-29
Journal: Scientific Reports [Category] COVID-19, MERS, SARS,

Neutralizing Antibody Therapeutics for COVID-19

COVID-19에 대한 중화 항체 치료제

Review

Published on 2021-04-072022-09-01
Journal: Viruses [Category] SARS, 변종, 진단, 치료제,

[키워드] administration ambulatory patient ambulatory patients Antiviral Antiviral treatment authorization bamlanivimab Casirivimab Clinical management COVID-19 COVID-19 pandemic COVID-19 patient drug Drug administration effective Emergency Emergency use authorization etesevimab European Medicines Agency food global public health high risk highlighting Hospitalized hospitalized patient hospitalized patients Imdevimab IMPROVE monotherapy mutant NAb NAbs neutralizing antibody Occurrence oxygen Patient progressed Prophylactic Prophylaxis Randomized controlled trial resistance risk SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody severe COVID-19 severe disease subsequent supplemental oxygen susceptibility Therapeutic strategies Therapeutics Treatment US Food and Drug Administration variant with COVID-19
[DOI] 10.3390/v13040628 PMC 바로가기 [Article Type] Review

Combination therapy protects macaques against advanced Marburg virus disease

Article

Published on 2021-03-252022-10-04
Journal: Nature Communications [Category] 비임상, 치료제,

Fever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report

Case Report

Published on 2021-03-122022-10-27
Journal: BMC Geriatrics [Category] COVID-19,

Fever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report

Case Report

Published on 2021-03-122022-10-27
Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, SARS,

Effect of Hydroxychloroquine and Azithromycin on QT Interval Prolongation and Other Cardiac Arrhythmias in COVID-19 Confirmed Patients

Research Article

Published on 2021-02-272022-10-31
Journal: Cardiovascular Therapeutics [Category] COVID-19,

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

SARS-CoV-2 감염의 햄스터 모델에서 메틸프레드니솔론과 렘데시비르 조합의 유익한 효과

Coronaviruses

Published on 2021-02-252022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Anti-inflammatory Antibody Response antibody response against Antiviral antiviral therapy benefit body weight Body weight loss boost caused clinical trials Combination combination therapy coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroid COVID-19 Cytokines Dexamethasone effective Efficacy expression glucocorticoid Glucocorticoids group hospitalized patients human monocyte-derived macrophages Inflammation macrophages Methylprednisolone monotherapy nasal Prevent prevented Proinflammatory cytokine proinflammatory cytokines pulmonary inflammation Randomized Receptor-binding domain Remdesivir replication of SARS-CoV-2 respiratory RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus shown Spike protein Support suppressed survival the receptor-binding domain Treatment Viral Viral load viral loads Viral protein weight loss
[DOI] 10.1080/22221751.2021.1885998 PMC 바로가기 [Article Type] Coronaviruses

A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

COVID-19 환자의 바이러스 운반에 대한 하이드록시클로로퀸과 아지트로마이신의 영향에 대한 베이지안 재분석

Comparative Study

Published on 2021-02-192022-09-10
Journal: PLoS ONE [Category] MERS, 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyses applied assumed assumption Azithromycin Bayesian case sery coronavirus dual Effect effective Effects Evidence examined exclusion HCQ Hydroxychloroquine include Inclusion Interpretation moderate monotherapy no effect paper Patient patients patients with COVID-19 performed positive raise ranged reducing reduction reported respiratory robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 statistical the patient These data Treatment upper respiratory tract variant variants Viral Viral load virus were excluded
[DOI] 10.1371/journal.pone.0245048 PMC 바로가기 [Article Type] Comparative Study

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial

경증에서 중등도의 COVID-19 환자의 바이러스 부하에 대한 밤라니비맙 단독 요법 또는 에테세비맙 병용 요법의 효과: 무작위 임상 시험

Clinical Trial

Published on 2021-02-162022-09-25
Journal: JAMA [Category] MERS, 임상, 진단, 치료법, 치료제,

[키워드] 95% CI acute respiratory syndrome age ambulatory patient Analysis antibody bamlanivimab baseline clinical clinical benefit Clinical outcome clinical trial combination therapy combination treatment comparison coronavirus Coronavirus disease 2019 COVID-19 death determine Effect Efficacy End points enrolled etesevimab evaluated evaluation period events Final Hospitalization hypersensitivity reaction Immediate in viral load log measure Mild moderate Moderate COVID-19 monotherapy NCT04427501 neutralizing antibody no significant difference occurred outcome Patient patients with COVID-19 phase 2/3 trial Placebo positive Potential treatment primary end point proportion Randomized receive reduction reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load secondary outcome measure secondary outcome measures Spread statistically significant statistically significant reduction Symptoms tested the placebo group Treatment treatment group Viral load women
[DOI] 10.1001/jama.2021.0202 PMC 바로가기 [Article Type] Clinical Trial

Molecular docking analysis of azithromycin and hydroxychloroquine with spike surface glycoprotein of SARS-CoV-2

Research Article

Published on 2021-01-312022-10-28
Journal: Bioinformation [Category] COVID-19,

[키워드] Administered affected Analysis binding binding pocket Combination COVID-19 docking drugs feature HCQ Hydroxychloroquine molecular molecular docking molecular docking analysis monotherapy Patient pharmacokinetics positive SARS-CoV-2 structure activity relationship Surface glycoprotein tested virus
[DOI] 10.6026/97320630017011 PMC 바로가기 [Article Type] Research Article