Discriminatory Weight of SNPs in Spike SARS-CoV-2 Variants: A Technically Rapid, Unambiguous, and Bioinformatically Validated Laboratory ApproachArticle Published on 2022-01-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Alpha variant analyses Analysis assigned assumed Beta bioinformatic validation COVID-19 COVID-19 pandemic COVID-19 variants demonstrated Gamma greater identify Lineage Mutation mutations N gene N501Y PCR Rapid Reactions reliability S gene Sanger sequencing SARS-CoV-2 SARS-CoV-2 virus selected SNP spike Spread statistical unique variant variants weight whole-genome sequencing [DOI] 10.3390/v14010123 PMC 바로가기 [Article Type] Article
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) VariantsSARS-CoV-2에 대한 신속한 항원 검출 테스트는 COVID-19 양성 사례의 식별을 과소평가하고 SARS-CoV-2(K417N/T, E484K 및 N501Y) 변이체의 진단을 손상시킵니다Public Health Published on 2022-01-032022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 치료기술, [키워드] acute respiratory syndrome amplification Antigen appearance applied Beta Chain Reaction circulation compromise coronavirus COVID-19 COVID-19 diagnosis COVID-19 false negative rapid test for COVID-19 diagnosis Cq value detection detection efficiency Detection sensitivity Diagnosis diagnosis of COVID-19 E484K evaluate evaluated False negative false negatives faster generate gold identification K417N less methodology N501Y new SARS-CoV-2 nucleotide Outbreaks pandemic pandemic control strategies polymerase chain polymerase chain reaction positive Quantitative Rapid rapid antigen test respiratory reverse transcription reverse transcription quantitative polymerase chain reaction RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant SARS-CoV-2 variants SD Biosensor Sensitivity and specificity Severe acute respiratory syndrome Single nucleotide polymorphism single nucleotide polymorphisms SNP South Korea Test the SARS-CoV-2 variant Viral Viral variants was obtained [DOI] 10.3389/fpubh.2021.780801 PMC 바로가기 [Article Type] Public Health
Detection of a SARS-CoV-2 P.1.1 variant lacking N501Y in a vaccinated health care worker in Italy이탈리아에서 예방 접종을 받은 의료 종사자에서 N501Y가 결여된 SARS-CoV-2 P.1.1 변이체 검출Comment Published on 2022-01-012022-09-11 Journal: The Journal of Infection [Category] Fulltext, SARS, 변종, 치료기술, [키워드] Care detection Health Italy N501Y SARS-CoV-2 variant [DOI] 10.1016/j.jinf.2021.06.026 PMC 바로가기 [Article Type] Comment
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicineSARS-CoV-2 계통 중 Omicron N501Y 돌연변이: 티로신 키나아제 및 가상의 용도 변경 의약품에 대한 강력한 결합의 인실리코 분석Article Published on 2022-01-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 신약개발, [키워드] Analysis analyzed applied B.1.1.7 B.1.351 binding Cancer Cancer patients Care EGFR elevated ENhance enrichment Factor host cell host cells hypothetical Interaction kinase kinases Lineage lineages management molecular docking analysis Mutation N501Y N501Y mutation network network pharmacology omicron pandemic pathogenic Pathways Phosphorylation PI3K polar Precision predicted Receptor binding domain SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 lineage Signaling Spike receptor binding domain therapy tyrosine variants [DOI] 10.1016/j.tmaid.2021.102242 PMC 바로가기 [Article Type] Article
Monitoring the SARS-CoV-2 pandemic: screening algorithm with single nucleotide polymorphism detection for the rapid identification of established and emerging variantsSARS-CoV-2 대유행 모니터링: 확립된 변이체 및 신규 변이체의 신속한 식별을 위한 단일 염기 다형성 검출을 통한 스크리닝 알고리즘Article Published on 2022-01-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Alpha applied assessment Beta Chain Reaction Concordance coronavirus coronavirus disease Coronavirus disease 2019 Delta determine disease E484K Epsilon Eta evaluate evaluated failure flexible Gamma gene mutations H655Y identify include L452R Lineage Local melting melting curve analysis monitoring Multiplex PCR N501Y nucleic acid testing P681R pangolin Pangolin lineage PCR performed polymerase chain reaction polymorphism positive sample S-gene mutation S-gene mutations SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 viral RNA Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2 variants single nucleotide Single nucleotide polymorphism SNP SNPs target Testing Testing algorithm the SARS-CoV-2 variant variants Viral RNA was performed WGS whole-genome sequencing [DOI] 10.1016/j.cmi.2021.09.007 PMC 바로가기 [Article Type] Article
A low-cost TaqMan minor groove binder probe-based one-step RT-qPCR assay for rapid identification of N501Y variants of SARS-CoV-2SARS-CoV-2의 N501Y 변이체를 신속하게 식별하기 위한 저비용 TaqMan 작은 홈 결합제 프로브 기반 1단계 RT-qPCR 분석Article Published on 2022-01-012022-09-11 Journal: Journal of virological methods [Category] SARS, 변종, 치료기술, [키워드] Accuracy allele frequency analytical sensitivity B.1.1.7 B.1.351 collected COVID-19 detect determine diagnostic Diagnostic accuracy evaluated expand Frequency Genome Genome sequencing gold gold standard health authorities house identify in some Lineage low frequency Mutation N501Y N501Y mutation N501Y variants One-step RT-qPCR positive Prevalence qPCR qPCR assay reduced reference standard respiratory specimen respiratory specimens robust RT-qPCR SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing Surveillance TaqMan time-consuming Transmissibility variant variant of concern variants variants of concern variants of SARS-CoV-2 whole-genome sequencing widespread wildtype [DOI] 10.1016/j.jviromet.2021.114333 PMC 바로가기 [Article Type] Article
Haplotype distribution of SARS-CoV-2 variants in low and high vaccination rate countries during ongoing global COVID-19 pandemic in early 20212021년 초 글로벌 COVID-19 대유행이 진행되는 동안 백신 접종률이 낮거나 높은 국가에서 SARS-CoV-2 변이체의 일배체형 분포Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] A222V A570D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Canada characterized Complete coronavirus country COVID-19 outbreak COVID-19 pandemic COVID19 D614G distribution dominant effort Epitopes evade furin furin cleavage site genome sequence Germany group Haplotype haplotypes help Impact India indicated L452R Malaysia maximum Mutation N501Y neutralization new SARS-CoV-2 Nsp12 Ongoing pandemic P323L P681H pandemic Partly vaccinated rate pathogenic profile profiles Profiling Protein proteome proteomes public health Research response to vaccination S982A SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein T19R T478K T716I Taiwan Transmissibility vaccination vaccination rate Vaccination strategies Vaccine-induced immunity variant viral mutation Viral mutations widespread [DOI] 10.1016/j.meegid.2021.105164 PMC 바로가기 [Article Type] Article
Chimeric crRNA improves CRISPR–Cas12a specificity in the N501Y mutation detection of Alpha, Beta, Gamma, and Mu variants of SARS-CoV-2Chimeric CrRNA는 SARS-COV-2의 알파, 베타, 감마 및 MU 변형의 N501Y 돌연변이 검출에서 CRISPR – CAS12A 특이성을 향상시킵니다.Research Article Published on 2021-12-232022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] Alpha Beta chimeric CRISPR Critical detect Gamma IMPROVE N501Y N501Y mutation nucleotide platform SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity specificity variants variants of SARS-CoV-2 [DOI] 10.1371/journal.pone.0261778 PMC 바로가기 [Article Type] Research Article
Wastewater SARS-CoV-2 monitoring as a community-level COVID-19 trend tracker and variants in Ohio, United States미국 오하이오주의 커뮤니티 수준 COVID-19 추세 추적기 및 변종으로 폐수 SARS-CoV-2 모니터링Article Published on 2021-12-202022-09-11 Journal: The Science of the total environment [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 average B.1.427/429 can be used capital city caused Clinical data clinical isolates complementary Concentration confirmed cases confirmed COVID-19 case coronavirus correlated correlation COVID-19 COVID-19 case COVID-19 cases crAssphage. D614G determine E gene effective Effectiveness Epidemiology evaluated fecal gene regions global pandemic Health authority help isolate Longitudinal data N1 and N2 N501Y pandemic performed PMMoV Quadratic polynomial model quantified reduce SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus significantly Spearman statistical model Support Surveillance surveillance data target gene tested the SARS-CoV-2 Transmission United State vaccination variant variants variants of concern variants of SARS-CoV-2 Variation virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.149757 PMC 바로가기 [Article Type] Article