Understanding of COVID-19 Pathology: Much More Attention to Plasma ProteinsImmunology Published on 2021-03-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ARDS Attention COVID-19 Histidine-rich glycoprotein immunothrombosis inter-alpha inhibitor proteins NETs understanding [DOI] 10.3389/fimmu.2021.656099 PMC 바로가기 [Article Type] Immunology
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19SARS-CoV-2와 hemophagocytic lymphohistiocytosis 유전자의 상호 작용에 대한 네트워크 기반 분석은 COVID-19의 혈전증 매개체로서 호중구 세포외 트랩을 가리킵니다.Research Article Published on 2021-03-082022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] abnormal coagulation acting Adults Algorithm Algorithms Analysis approach children circulating co-morbidities co-morbidity Coagulation concert condition consequence COVID-19 described disease Diseases Endothelium environmental condition environmental conditions Epidemic extracellular trap extracellular traps favor feature Genetic genetic information H1N1 H1N1 influenza hematologic hemophagocytic lymphohistiocytosis HLH Host host gene hyperinflammation Hypothesis identify Immune cell immune cells increase increased risk individual inflammatory condition inflammatory conditions inflammatory process inflammatory signal inflammatory signals Influenza information Interaction life-threatening likelihood manuscript mechanism mediators Metabolic disorders morbidities NET NETs network neutrophil Neutrophils Pathogenesis pathogenic pathway Pathways potential mechanism potential molecular predict presenting problem Pulmonary thromboembolism regulate responsible risk SARS-CoV-2 serious complication severe COVID-19 severely ill patient severely ill patients similarities similarity tested Thromboembolism thrombosis thrombotic thrombotic complication Thrombotic complications trajectory underlying condition underlying conditions vascular thrombosis Viral protein Viral proteins [DOI] 10.1371/journal.pcbi.1008810 PMC 바로가기 [Article Type] Research Article
Blood myeloperoxidase-DNA, a biomarker of early response to SARS-CoV-2 infection?SARS-CoV-2 감염에 대한 초기 반응의 바이오마커인 Blood myeloperoxidase-DNA?Article Published on 2021-03-012022-09-11 Journal: Allergy [Category] MERS, SARS, 바이오마커, [키워드] Abstract Biomarker COVID-19 early response Innate immunity myeloperoxidase NETs neutrophil neutrophil extra-cellular traps (NETs) Neutrophils SARS-CoV-2 [DOI] 10.1111/all.14533 PMC 바로가기 [Article Type] Article
Neutrophil Extracellular Traps in SARS-CoV2 Related Pneumonia in ICU Patients: The NETCOV2 StudyMedicine Published on 2021-02-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Analysis association Blood Blood level Coagulation Concentration coronavirus COVID-19 patients COVID19 decrease defined described died disease Extracellular extracellular trap flow cytometry Hypoxemia ICU ICU admission Infectious disease Inflammatory inflammatory status intensive care lack male median Mortality multivariable NET NETs neutrophils extracellular traps neutrophils extracellular traps PaO pathway Patient patients who survived Pneumonia Primary outcome quantification quantified remained Respiratory failure SARS-CoV-2 SARS-CoV2 severe hypoxemia significantly therapeutic target Whole blood whole blood sample [DOI] 10.3389/fmed.2021.615984 PMC 바로가기 [Article Type] Medicine
The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?Perspective Published on 2021-02-162022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] accumulate acute respiratory distress acute respiratory syndrome Bacterial coinfection balance boost Coinfection Contact contribute coronavirus COVID-19 COVID-19 patient Defense Degradation degrade described detrimental effect DNase Evidence extracellular DNA fiber Formation Host humans immunothrombosis Infection NET NETs neutrophil Neutrophil extracellular trap Neutrophils Nuclease Pathogenesis peptides public health released role SARS-CoV-2 severe COVID-19 severe SARS-CoV-2 severity syndrome the disease therapeutic strategy Treatment treatment strategy Unknown Vascular [DOI] 10.1128/mBio.03304-20 PMC 바로가기 [Article Type] Perspective
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patientsResearch Published on 2021-02-082022-11-01 Journal: Critical Care [Category] COVID-19, MERS, [키워드] Activation anaphylatoxin antibodies Bilirubin block carboxypeptidase Carboxypeptidase B cascade CCK-8 assay Cell cell-free DNA Coagulation Coagulopathy complement component contribute COVID-19 COVID-19 patient COVID-19 patients CPB2 Critically ill patient cytotoxicity Degradation degrade demonstrated Disease progression endothelial enzyme evaluated Ex vivo Extracellular help homolog Immunofluorescent staining immunothrombosis inactive Intervention lactate dehydrogenase myeloperoxidase NET NETs neutrophil Neutrophil extracellular trap pathological role plasma prevalent Prevent proinflammatory mediators recruited Regulation Result risk of death thrombosis thrombotic event total bilirubin Vascular vascular endothelial cell with COVID-19 [DOI] 10.1186/s13054-021-03482-z PMC 바로가기 [Article Type] Research
Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다Article Published on 2021-02-012022-09-11 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19 [DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article
Significance of NETs Formation in COVID-19Review Published on 2021-01-142022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE2 base cellular combating contagious coronavirus Course COVID-19 COVID-19 in patient COVID-19 pathogenesis elevated enzyme excessive inflammatory response Extracellular Formation IMPROVE Inflammation Interaction manuscript mechanism medication Metabolic diseases molecular NET NETs neutrophil Neutrophils Occurrence organs pathogenesis of COVID-19 Pathogens patients protease protein S reaction recruitment Regulatory Research Respiratory failure SARS-CoV-1 SARS-CoV-2 serine 2 Significance Spread Stress the SARS-CoV-2 therapeutic strategy therapy thromboembolic complication tissue TMPRSS2 Treatment [DOI] 10.3390/cells10010151 PMC 바로가기 [Article Type] Review
The interplay between neutrophils, complement, and microthrombi in COVID-19Article Published on 2021-01-132023-06-16 Journal: Best practice & research. Clinical rheumatology [Category] MERS, SARS, [키워드] complement COVID-19 Innate immunity NETs Neutrophil extracellular traps SARS-CoV-2 thrombotic microangiopathy [DOI] 10.1016/j.berh.2021.101661 PMC 바로가기
Preventing the development of severe COVID-19 by modifying immunothrombosis면역혈전증을 변형시켜 중증 코로나19 발병 예방Review Published on 2021-01-012022-09-12 Journal: Life sciences [Category] MERS, SARS, 진단, [키워드] activated Activation acute respiratory distress alveolar alveolar cell alveolar epithelial cell alveolar macrophage ARDS chemokine Combination complexes COVID-19 Endothelial cell immunothrombosis include Infection Inflammation inflammatory mediator initial involved Macrophage Migration morbidity Mortality necroptosis NETs neutrophil Neutrophil extracellular trap NLRP3 pathophysiology Platelet Preventing producing Proinflammatory cytokine pyroptosis respiratory respiratory infection SARS-CoV-2 severe COVID-19 subsequent syndrome tissue damage translocation Treatment Vascular vascular endothelial cell vasculature [DOI] 10.1016/j.lfs.2020.118617 PMC 바로가기 [Article Type] Review