Metabolic impact of weight loss induced reduction of adipose ACE-2 – Potential implication in COVID-19 infections?Randomized Controlled Trial Published on 2020-12-012022-10-05 Journal: Metabolism: clinical and experimental [Category] SARS, 임상, [키워드] ACE-2 adipose Adipose tissue Affect age analyzed angiotensin BMI cell entry changes in characterized Clamp control group COVID-19 downregulation enzyme expression Glucose improvement insulin insulin resistance Insulin sensitivity Intervention ISI liver metabolic metabolism modulation mRNA expression not affected obesity Potential predicted preserved Randomized receptor reduction Regulation responsible SARS-CoV-2 sensitivity Skeletal muscle subject subjects tissue tissue metabolism Trial was measured was reduced weight weight loss [DOI] 10.1016/j.metabol.2020.154401 PMC 바로가기 [Article Type] Randomized Controlled Trial
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다Article Published on 2020-11-302022-09-11 Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단, [키워드] abrogate ACE2 ACE2‐Fc activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin II antibody block cascade caused cells cellular receptor Characteristics circumvent coronavirus COVID‐19 COVID‐19 cytokine D614G variant D614G variants decoy antibody degranulation demonstrated develop domain effective enzyme fusion protein H1975 humanized immunology impairment Infection Interaction lung cell lung cells lung organoids Microbiology, Virology & Host Pathogen Interaction NK cell not affected pandemic peptidase preservation Prevent Pseudotyped virus reduce respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus shown Spike protein Strains therapeutic Treatment Viral viral entry viral spike protein virus infection virus replication virus variants [DOI] 10.15252/emmm.202012828 PMC 바로가기 [Article Type] Article
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBsArticle Published on 2020-10-282022-10-04 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, [키워드] abundantly expressed ACE inhibitor ACE2 ACE2 expression ACE2 receptor ACE2 receptor protein ACEi acute respiratory disease airway airway epithelial cells angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor ARB ARBs blocker blockers cellular tropism ciliary Clinical characteristics Comorbidities coronavirus SARS-CoV-2 COVID-19 demographics determine Evidence expression Host human donor initial medication Motile cilia nasal not affected pandemic pathogen pathogenesis of SARS-CoV-2 Patient receptor respiratory cilia respiratory tract Respiratory tract diseases SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral subcellular subcellular localization susceptibility the SARS-CoV-2 tissues Transmission transmission of SARS-CoV-2 understanding viral infection virulent [DOI] 10.1038/s41467-020-19145-6 PMC 바로가기 [Article Type] Article
Sensitive detection and quantification of SARS-CoV-2 by multiplex droplet digital RT-PCR다중 액적 디지털 RT-PCR을 통한 SARS-CoV-2의 민감한 검출 및 정량화Original Article Published on 2020-10-262022-09-10 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] COVID-19 patients criteria ddPCR detectable develop dilution series DNA gold gold standard GUSB housekeeping gene MONITOR monitoring mRNA multiplex Multiplex assay not affected nucleic acid patients quantification RdRP RNA robust RPP30 RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 RNA sensitive sensitivity transcript Validity Viral Viral load viral loads Viral RNA was used water [DOI] 10.1007/s10096-020-04076-3 PMC 바로가기 [Article Type] Original Article
Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving HospitalInternal Medicine Published on 2020-10-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour 24 hours 95% CI 95%CI Administered age analyzed chi-square test chronic obstructive co-morbid conditions co-morbidities co-morbidity Comorbidities Comparative COVID-19 cross-sectional determine diabete Diabetes Mellitus Frequency Gender hypertension IBM ICU IMV independent risk factor independent t-test intensive care Invasive mechanical ventilation less likelihood LOS Major Mortality mortality rate multivariable multivariate regression analysis NIV not affected objective overall mortality Patient patients predict pulmonary disease Result retrieved severe COVID-19 SPSS survival survivor the mean variable variables Ventilation ventilatory was used were used [DOI] 10.7759/cureus.10906 PMC 바로가기 [Article Type] Internal Medicine
Modelling and predicting the spatio-temporal spread of cOVID-19 in ItalyResearch Article Published on 2020-09-232022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] affected aggregation available data China Contagion Containment measure coronavirus 2 Coronavirus disease 2019 country COVID-19 COVID-19 infection diffusion disease distribution Effect effective European Evidence Evolution Generalized linear model health emergency homogeneous Infection Interaction International involved Italian Italy limit Local measure National not affected number of infected official pandemic predict prevalent Prevent provide respiratory Result SARS-CoV-2 Scientific community Spatio-temporal model Spread spread to the disease The United States Transmission union while [DOI] 10.1186/s12879-020-05415-7 PMC 바로가기 [Article Type] Research Article
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike VariantD614G 스파이크 변이체 출현 후 SARS-CoV-2에 대한 결합된 현장 진료 핵산 및 항체 테스트Report Published on 2020-09-012022-09-10 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% CI Accuracy acid amplification anti-spike antibodies anti-spike antibody antibody Antibody test antibody tests Blood Combined CoV COVID-19 COVID-19 diagnosis COVID-19 disease cross-react D614G detect detection rate diagnose diagnosis of COVID-19 diagnostic Diagnostic accuracy emergence False positivity Finger prick hospital immune response immune responses IMPROVE mutant Mutant SARS-CoV-2 NAAT nose/throat swab not affected nucleic acid nucleic acid amplification nucleic acid amplification testing Nucleic acid detection pandemic POC point of care point of care testing Rapid Rapid antibody tests rapid diagnoses report SARS-CoV-2 SARS-CoV-2 antibody test SARS-CoV-2 nucleic acid sensitivity serological test Serological tests specificity spike Spike D614G variant Testing the SARS-CoV-2 variant wild-type [DOI] 10.1016/j.xcrm.2020.100099 PMC 바로가기 [Article Type] Report
Compassionate use of JAK1/2 inhibitor ruxolitinib for severe COVID-19: a prospective observational study중증 COVID-19에 대한 JAK1/2 억제제 룩소리티닙의 동정적 사용: 전향적 관찰 연구Clinical Trial Published on 2020-08-192022-08-13 Journal: Leukemia [Category] MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% confidence interval activated adverse event age Anemia anti-inflammatory properties clinical Clinical improvement Comorbidities Comorbidity compassionate-use compassionate-use protocol contribute Controlled clinical trial controlled clinical trials COVID-19 cumulative incidence cytokine defined discharge home distress Efficacy exposure time FiO2 high-flow oxygen support improvement Infectious diseases Inflammatory cytokine inflammatory cytokine profile inflammatory reaction inhibitor JAK1 JAK1/JAK2 inhibitor JAK2 less lymphocyte Lymphocyte subset median age median dose intensity not affected observational study Ordinal Scale overall survival oxygen oxygen saturation PaO2 paO2/fiO2 PaO2/FiO2 ratio Patient patients with COVID-19 prospective cohort prospective observational study pulmonary disease Pulmonary function pulmonary infiltrate pulmonary infiltrates respiratory distress ruxolitinib Safe severe COVID-19 severe pulmonary disease Therapeutics thrombocytopenia urinary tract infections [DOI] 10.1038/s41375-020-01018-y PMC 바로가기 [Article Type] Clinical Trial
Health-Related Quality of Life and Experiences of Sarcoma Patients during the COVID-19 PandemicArticle Published on 2020-08-142022-10-31 Journal: Cancers [Category] COVID-19, [키워드] 350 patient affected benefit Cancer Care Complete COVID-19 COVID-19 infection COVID-19 pandemic emotional experience HRQoL Insomnia investigated life lockdown median age Modification modifications MOST not affected outcomes pandemic Patient Patient experience psychological support Quality Quality of life Sarcoma sarcomas significantly significantly higher Treatment with COVID-19 Worry [DOI] 10.3390/cancers12082288 PMC 바로가기 [Article Type] Article
Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic DonorsArticle Published on 2020-08-072022-10-28 Journal: Biology [Category] COVID-19, [키워드] ACE2 ACE2 expression ADAM17 adipose age binding BMI cells correlated COVID-19 diabete diabetes Diabetic diabetics Donor donors Endocrine entry of SARS-CoV-2 explain Express expression expression data expression level expression pattern female Gender Human human islets islet islets Microarray not affected occur pancreatic pancreatic islet pancreatic islets patients priming profile promote receptor required Revealed RNA-Seq RNA-sequencing S1 protein SARS-CoV-2 severity of COVID-19 significantly higher significantly increased statistically Symptom T2D the S protein thought tissue TMPRSS2 TMPRSS2 expression Variation viral spike [DOI] 10.3390/biology9080215 PMC 바로가기 [Article Type] Article