SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the NucleusResearch Article Published on 2011-05-272022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence Affect Amino acid Apoptosis caspase-3 Cell cellular Critical death Degradation diffuse elevated export found host cell independent induce influence inhibitors interact Interaction Mediated NES NLS nuclear nuclear localization signal nucleus principal Protein SARS-CoV shown transiently transfected Transport Trigger [DOI] 10.1371/journal.pone.0019436 PMC 바로가기 [Article Type] Research Article
The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-QuadruplexesResearch Article Published on 2009-05-152022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome ADP-ribose amino-acid Apoptosis Author bats bind binding coding compared component concerning coronavirus crystal structure determine determined different domain Evidence extreme form found function functional G-quadruplex gel electrophoresis Genome genomic RNA help homodimer host cell humans immune response in vitro include Infected involved lysine macrodomain mild infection monomer mRNA Mutation non-structural protein nucleic acid nucleotides nucleus occur oligonucleotide other coronaviruses outbreak pathogenicity Possible Protein protein 3 reduction Region regulate related virus remained Replication residue residues responsible RNA SARS Coronavirus SARS-CoV selected Seven shown Signal transduction Structure structures target three-dimensional structure Transcription viral infection viral replication virus X-ray crystallography [DOI] 10.1371/journal.ppat.1000428 PMC 바로가기 [Article Type] Research Article