Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient GroupsArticle Published on 2021-04-242022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adjuvant Administered Blood CD4 clinical trial COVID-19 eight ELISpot assay group healthy high-risk patient High-risk patients HLA molecules HLA-DR intracellular cytokine staining lipopeptide lymphocyte mononuclear cell peptide peptide vaccine performed peripheral predicted predominant SARS-CoV-2 second set single subcutaneous injection Support T cell epitope T cell response TLR vaccination Vaccine weakened were assessed [DOI] 10.3390/vaccines9050428 PMC 바로가기 [Article Type] Article
Early immune responses and prognostic factors in children with COVID-19: a single-center retrospective analysisResearch Article Published on 2021-04-172022-10-28 Journal: BMC Pediatrics [Category] COVID-19, MERS, [키워드] analyzed B cell Blood blood lymphocyte caused Cell cell count children children with COVID-19 concentrations conducted COVID-19 Critical critical cases cytokine Decreased diagnostic disease severity early diagnosis eosinophil ferritin group hemoglobin Hemoglobin concentration IFN-γ IL-10 IL-6 immune characteristics immune dysregulation immune response Inflammatory Inflammatory factor initial Lymphocyte count Lymphocyte subset natural killer peripheral procalcitonin procalcitonin level Prognostic factor progression RBC reduced Result Retrospective analysis Retrospective study SAA SARS-CoV-2 SARS-COV-2 infection Severe case severe disease significantly significantly increased significantly lower single-center statistically subset systemic cytokine T lymphocyte [DOI] 10.1186/s12887-021-02561-y PMC 바로가기 [Article Type] Research Article
Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by DexamethasoneOriginal Article Published on 2021-04-162022-10-30 Journal: Inflammation [Category] COVID-19, MERS, SARS, [키워드] Activation anti-inflammatory activity blocked caused clinical benefit COVID-19 Cytokine storm Cytokines Degradation Dexamethasone DNA binding Effect experiment Human IL-1β IL-6 IL-8 increase in induction Inflammation Inflammatory inhibition investigated involved IκBα MAPK mechanism molecular mononuclear cell NF-KB NF-κB NF-κB activation NLRP3 inflammasome p65 PBMC PBMCs peripheral Peripheral blood pharmacological target Phosphorylation pro-inflammatory cytokine produced Production recombinant reducing reduction reduction in SARS-CoV-2 SARS-CoV-2 cytokine storm SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein S1 SARS-CoV-2 virus infection significantly increased spike spike glycoprotein stimulated Stimulation TNFα was reduced [DOI] 10.1007/s10753-021-01464-5 PMC 바로가기 [Article Type] Original Article
Effects of Coronavirus Disease 2019 (COVID-19) on Peripheral Blood Lymphocytes and Their Subsets in Children: Imbalanced CD4 + /CD8 + T Cell Ratio and Disease SeverityPediatrics Published on 2021-04-142022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abnormality acute respiratory syndrome Analysis analyzed CD4 CD4+/CD8+ lymphocytes CD8 center children complete blood count coronavirus COVID-19 cytokine described disease Effect group hematological hospitalized patient Hyper-inflammatory responses immune response immune system laboratory feature lymphocyte lymphocyte subpopulation Lymphocyte subset lymphopenia Medical Sciences Mild Pathogenesis pathology Patient Pediatric patient peripheral Pneumonia Ratio real-time RT-PCR reported Sample size SARS-CoV-2 SARS-COV-2 infection Seven Severe case severe COVID-19 severe group severe pneumonia subject subset T cell Tehran the disease university while [DOI] 10.3389/fped.2021.643299 PMC 바로가기 [Article Type] Pediatrics
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
The value of lymphocyte count in determining the severity of COVID-19 and estimating the time for nucleic acid test results to turn negative코로나19 중증도 판단 및 핵산 검사 결과 음성 판정 시 림프구 수 값Research Article Published on 2021-04-012022-09-01 Journal: Bosnian Journal of Basic Medical Sciences [Category] 진단, [키워드] (hypertension age analyzed blood lymphocyte count Campus chronic disease Chronic diseases Clinical data conditions Coronary heart disease COVID-19 COVID-19 patient COVID-19 severity Critical Critically ill Critically ill patient critically ill patients cutoff value diabetes disease severity early stage effective Gender heart disease hypertension Indicator lymphocyte Lymphocyte count male nucleic acid nucleic acid test Patient patients with COVID-19 peripheral Peripheral blood predict reduction SARS-CoV-2 nucleic acid SARS-CoV-2 nucleic acid test Science severely ill patients severity severity of COVID-19 shown technology test results the disease Tongji Medical College turn union Union Hospital university West [DOI] 10.17305/bjbms.2020.4868 PMC 바로가기 [Article Type] Research Article
The value of lymphocyte count in determining the severity of COVID-19 and estimating the time for nucleic acid test results to turn negativeResearch Article Published on 2021-04-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] COVID-19, [키워드] age analyzed blood lymphocyte count Campus chronic disease Clinical data conditions Coronary heart disease COVID-19 COVID-19 patient COVID-19 severity Critical Critically ill Critically ill patient cutoff value diabetes early stage effective Gender hypertension Lymphocyte count male nucleic acid test Patient patients with COVID-19 peripheral predict reduction SARS-CoV-2 nucleic acid SARS-CoV-2 nucleic acid test Science severely ill patients severity severity of COVID-19 shown technology the disease Tongji Medical College turn Union Hospital university West [DOI] 10.17305/bjbms.2020.4868 PMC 바로가기 [Article Type] Research Article
The value of lymphocyte count in determining the severity of COVID-19 and estimating the time for nucleic acid test results to turn negativeResearch Article Published on 2021-04-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] Coronavirus, COVID-19, Fulltext, MERS, [키워드] age analyzed blood lymphocyte count Campus chronic disease Clinical data conditions Coronary heart disease COVID-19 COVID-19 patient COVID-19 severity Critical Critically ill Critically ill patient cutoff value diabetes early stage effective Gender hypertension Lymphocyte count male nucleic acid test Patient patients with COVID-19 peripheral predict reduction SARS-CoV-2 nucleic acid SARS-CoV-2 nucleic acid test Science severely ill patients severity severity of COVID-19 shown technology the disease Tongji Medical College turn Union Hospital university West [DOI] 10.17305/bjbms.2020.4868 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2-Associated Guillain-Barre Syndrome Obscured by Diabetes Mellitus Peripheral NeuropathyInternal Medicine Published on 2021-03-312022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome association baseline coronavirus COVID-19 deviate diabete diabetes Diabetic diagnosed Guillain-barrè syndrome Human immunodeficiency virus individual Influenza male Middle East Multiple Neurological complications Neurological symptom Neuropathy outbreak peripheral positive Prevalence progressed reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Symptom syndrome thought Till virus Zika [DOI] 10.7759/cureus.14209 PMC 바로가기 [Article Type] Internal Medicine
Peripheral Blood Smears in COVID-19: A CommentLetters to the Editor Published on 2021-03-252022-10-28 Journal: Turkish Journal of Hematology [Category] Coronavirus, MERS, SARS, [키워드] Blood smear Comment COVID-19 Laboratory peripheral smear [DOI] 10.4274/tjh.galenos.2020.2020.0704 PMC 바로가기 [Article Type] Letters to the Editor