Virtual screening and dynamics of potential inhibitors targeting RNA binding domain of nucleocapsid phosphoprotein from SARS-CoV-2SARS-CoV-2의 뉴클레오캡시드 인단백질의 RNA 결합 도메인을 표적으로 하는 잠재적 억제제의 가상 스크리닝 및 역학Article Published on 2021-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Antiviral binding binding domain binding energy binding free energy calculated coronavirus coronavirus disease COVID-19 database databases docking docking process docking score docking scores drug exonuclease fluctuation genetic material hotspot inhibitor Interaction Ligand mechanism molecular molecular dynamics Molecular dynamics simulation N protein nucleocapsid Nucleocapsid phosphoprotein nucleocapsid phosphoprotein. outbreak pandemic Potential treatment Precision PubChem PubChem database remained required RMSD RMSF RNA SARS-CoV-2 selected Site target target protein transcribed Transcription unique viral replication virion Virtual screening virus zidovudine [DOI] 10.1080/07391102.2020.1778536 PMC 바로가기 [Article Type] Article
Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury치명적인 COVID-19 관련 폐 손상의 호중구 세포외 트랩Research Article Published on 2021-07-302022-09-10 Journal: Disease Markers [Category] 바이오마커, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome added addition alveolar alveolar damage ARDS association assumption Autopsy Capillaries contribute COVID-19 COVID-19 patients cytokine Cytokine storm damaged Diffuse alveolar damage Endothelial dysfunction Evidence feature histochemistry immunohistochemistry low-density lung damage lung tissue marker microthrombi molecular molecular markers Morphological NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Non-COVID-19 pathophysiology Potential treatment prevalent recent findings respiratory distress serological Seven severe COVID-19 shown syndrome thrombosis Vascular [DOI] 10.1155/2021/5566826 PMC 바로가기 [Article Type] Research Article
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19사하라 사막 이남 아프리카의 G6PD 분포 및 COVID-19에 대한 클로로퀸/하이드록시클로로퀸 기반 치료제 사용의 잠재적 위험Article Published on 2021-07-232022-09-10 Journal: The Pharmacogenomics Journal [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] African allele frequency Analysis Chloroquine chloroquine/hydroxychloroquine clinical trial clinical trials continent country COVID-19 deficiency Deleterious distribution drug G6PD Genetics research Genotype Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase Hydroxychloroquine individual nine potential risk Potential treatment potential treatments Predictive medicine Prevalence significant difference significant differences significant interaction South Africa sub-Saharan Africa Treatment treatments for COVID-19 variant variants Variation whole genome sequence [DOI] 10.1038/s41397-021-00242-8 PMC 바로가기 [Article Type] Article
Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation Research Published on 2021-07-152022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] ACE2 activated acute inflammatory response acute lung inflammation acute respiratory distress acute respiratory syndrome Administered administration AGT alleviate alteration antiviral activity Antiviral effect Cell controls coronavirus COVID-19 patient damaged EC50 entry of SARS-CoV-2 expressed expression HEK-293T cell in vitro in vivo induce infected with SARS-CoV-2 Infection inflammatory cell infiltration Inflammatory cytokines inhibit inhibited intravenous investigated low expression lung inflammatory response lung tissue mechanism mice Mortality mRNA level NF-κB Potential treatment progression respiratory inflammation Salvia miltiorrhiza SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S syndrome target cells Therapeutics TLR4 treated Treatment VERO-E6 virus virus assay VSV-G [DOI] 10.1038/s41401-021-00714-4 [Article Type] Research
In silico Screening of Natural Phytocompounds Towards Identification of Potential Lead Compounds to Treat COVID-19Molecular Biosciences Published on 2021-07-052022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Allium analyses Analysis approaches binding free energy catalytic dyad Compound conformational changes coronavirus COVID-19 Curcuma Cys145 died drug Drug discovery drugs His41 hotspot humans identification identify in silico Interaction involved M pro main protease Molecular dynamics simulation natural natural medicinal plants over parameters plant Potential Potential treatment Protein researcher residue S-ACE2 screened Screening selected stability Structure-based virtual screening the binding affinity viral entry Virtual screening Zingiber [DOI] 10.3389/fmolb.2021.637122 PMC 바로가기 [Article Type] Molecular Biosciences
Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2헤스페리딘에 의해 매개되는 항바이러스성 산화아연 나노입자와 항-SARS-CoV-2로서의 항바이러스성 페놀계 물질 간의 in silico 비교 연구Article Published on 2021-07-012022-09-11 Journal: Colloids and surfaces. B, Biointerfaces [Category] SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents assist caused characterized complementary Compound coronavirus COVID-19 curative death docking score evaluated example HAV Hepatitis hepatitis A hepatitis A virus hesperidin highest in silico Infection Isolation leads measure metabolite molecular docking nutraceutical nutraceuticals pandemic pharmaceutical Potential treatment predicted protocol protocols reducing reducing agent required respiratory responsible RNA viruses Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects synthesis TEM tested Treatment virus Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.1016/j.colsurfb.2021.111724 PMC 바로가기 [Article Type] Article
Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital MortalityCOVID-19 심각도 및 병원 내 사망률에 대한 예후 마커로서 아나필라톡신 및 염증성 사이토카인 보완Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] Activation Analysis anaphylatoxin anaphylatoxins C3a C5a changes in chemokine chemokines clinical disease clinical outcomes complement complement anaphylatoxins Complement pathway complement system complications COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patient critical COVID-19 patients critical patients cytokine Cytokine storm Cytokines deaths dysregulation enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls highlight Hospitalization IgM antibody IgM antibody levels IL-1β IL-6 IL-8 immunopathology In-hospital in-hospital mortality infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines Inflammatory mediators Innate immunity Interaction interleukin investigated mediators mild cases mild COVID-19 patients mild patient mild patients Mortality Necrosis outcome Patient patients patients with COVID-19 positively correlated Potential treatment Prognosis prognostic properdin Protein RANTES SARS-COV-2 infection SARS-CoV-2 infections SARS‐CoV‐2 SARS‐CoV‐2 sera serum severe SARS Signaling significantly significantly higher survival group target Treatment strategies treatment strategy Tumor tumor necrosis tumor necrosis factor upregulated utility were measured [DOI] 10.3389/fimmu.2021.668725 PMC 바로가기 [Article Type] Immunology
Environmental impact assessment of COVID-19 therapeutic solutions. A prospective analysisResearch article Published on 2021-07-012022-10-05 Journal: The Science of the total environment [Category] SARS, 치료제, [키워드] adverse effects Analysis Antibiotics antiparasitic Antiviral antiviral drug antiviral drugs antiviral medicine approach aquatic environment Chloroquine COVID-19 COVID-19 pandemic Dexamethasone Ecotoxicity read-across Effect emission Environmental impact Environmental risk EPA Glucocorticoids group Guidance highlight Human medicines identify in vitro data information Ivermectin medication offer pharmacokinetic pharmacological Potential treatment Prophylactic Quantitative resulting retrieved risk therapeutic Treatment [DOI] 10.1016/j.scitotenv.2021.146257 [Article Type] Research article
Clinical characterization and therapeutic targets of vitamin A in patients with hepatocholangiocarcinoma and coronavirus disease간도 콜랑 지오 마쇄종 및 코로나 바이러스 질환 환자에서 비타민 A의 임상 적 특성 및 치료 적 표적Research Paper Published on 2021-06-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Anti-inflammatory anti-inflammatory actions Anti-viral approach Bioinformatics analysis BRD2 CDK4 Cell Characteristics clinical Clinical finding Clinical findings Clinical management contribute coronavirus coronavirus disease COVID-19 CXCR3 database determine function genome analysis GPT hepatocholangiocarcinoma ICAM1 identify Immunity immunopotentiation inflammatory reaction MAPK1 mechanism mechanism of action Medicine molecular functions molecular mechanism molecular mechanisms morbidity and mortality mortality rate network pharmacology NOS2 oxidative stress Pathways Patient patients with COVID-19 pharmacological Potential treatment Prognosis recent recurrence Signaling suppression survival rate susceptibility target therapeutic therapeutic target TMPRSS13 Transcriptome Vitamin vitamin A were used [DOI] 10.18632/aging.203220 PMC 바로가기 [Article Type] Research Paper
Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceResearch Article Published on 2021-06-212022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] adipose Adults age aging beta coronavirus coronavirus Coronavirus infection COVID-19 infection decrease Defense expand gamma delta T cell Glycolysis hallmark immune Impact increased mortality Increasing Infection Inflammasome Inflammatory influenza infection inoculated intranasally ketogenic Ketogenic diet lung Lungs MHV MHV-A59 mice monocyte Mortality mouse mouse hepatitis virus murine NLRP3 inflammasome pathogenic Potential treatment PROTECT Protective risk of COVID-19 severity Surveillance systemic inflammation T cell T cells tissue [DOI] 10.7554/eLife.66522 PMC 바로가기 [Article Type] Research Article