Can follow up lung ultrasound in Coronavirus Disease-19 patients indicate clinical outcome?코로나 바이러스 질병 19 환자의 후속 폐 초음파를 임상 결과를 나타낼 수 있습니까?Research Article Published on 2021-08-252022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] analyzed association Can clinical Clinical outcome consolidation coronavirus disease Coronavirus disease 2019 COVID-19 patient COVID-19 patients defined determine disease end point evaluate Evolution Follow-up increase in intensive care intensive care unit lung lung involvement Lung pathology material outcome Pathologies pathology Patient powerful tool predict primary end point Result severe disease statistically significant subpleural [DOI] 10.1371/journal.pone.0256359 PMC 바로가기 [Article Type] Research Article
Use of research electronic data capture (REDCap) in a COVID-19 randomized controlled trial: a practical exampleCOVID-19 무작위 대조 시험에서 연구 전자 데이터 캡처 (REDCAP) 사용 : 실제 예Research Article Published on 2021-08-212022-09-10 Journal: BMC Medical Research Methodology [Category] Fulltext, MERS, SARS, 임상, [키워드] allocation sequence Antibody test Blinding can be used capture changed Complete component conducted confidentiality Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 Data collection defect Efficacy eligibility example feature Follow-up investigator investigators lab Longitudinal data offer parallel group powerful tool Protective protocols randomization Randomized Randomized controlled trials RCT RCTs receiving recruitment REDCap Registered Registration registration number reported Research Research Electronic Data Capture researcher Result Risk of bias SARS-CoV-2 antibody test secure supplementary material test results treatment arm Trial registration unique university web application XML [DOI] 10.1186/s12874-021-01362-2 PMC 바로가기 [Article Type] Research Article
Serological Testing for COVID-19, Immunological Surveillance, and Exploration of Protective AntibodiesCOVID-19에 대한 혈청학적 검사, 면역학적 감시 및 보호 항체 탐색Immunology Published on 2021-08-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 3CL animals antibody Antibody titer Antibody titers Antigen antigens Antiviral antiviral activity antiviral antibodies changes in circulation Combination Concentration correlation COVID-19 diagnosed Effectiveness ELISA assay Epidemiological study exploration greater human serum IgG IgG and IgM IgG antibody IgG level IgM antibodies IgM antibody immunoassay individual information Measures N protein neutralization activity nucleocapsid pathogenic PCR powerful tool protease reduction in SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins sensitivity serological Serological assay Serological testing seroneutralization shown target Testing Viral virus [DOI] 10.3389/fimmu.2021.635701 PMC 바로가기 [Article Type] Immunology
“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical MonitoringPreliminary Research Published on 2021-08-162022-10-30 Journal: Journal of Medical Toxicology [Category] Coronavirus, MERS, SARS, [키워드] aggregation analogue Analysis application Biomarker change COVID-19 disease COVID-19 pandemic develop disorder downstream drug drugs Epidemic Epidemiology fentanyl include manuscript medication metabolites MONITOR monitoring opioids Pathogens pharmaceutical plant powerful tool provide public health Research sewer Sewers Stimulants Surveillance System Treatment trend upstream Want wastewater [DOI] 10.1007/s13181-021-00853-4 PMC 바로가기 [Article Type] Preliminary Research
Integrated single-cell analysis revealed immune dynamics during Ad5-nCoV immunizationArticle Published on 2021-08-102022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] Analysis antibodies approach binding bioinformatics CDR3 Cell cellular immunity clone combating Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical domain driven by effective Evolution exhibited expressed Extracellular facilitate Health high affinity Humoral immunity identify IFN response immune immune response immunization immunology Infectious disease lineages monoclonal antibody mononuclear cell multicellular Peripheral blood powerful tool Prophylactic Protein public health RNA sequencing Safe SARS-CoV-2 SARS-CoV-2-specific antibodies scRNA-seq sequence single-cell spike tested the vaccine therapeutic trial participant Vaccine Vaccines [DOI] 10.1038/s41421-021-00300-2 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 spike glycoprotein‐reactive T cells can be readily expanded from COVID‐19 vaccinated donorsSARS-CoV-2 스파이크 당단백질 반응성 T 세포는 COVID-19 백신 접종 기증자로부터 쉽게 확장될 수 있습니다Original Article Published on 2021-07-272022-09-12 Journal: Immunity, Inflammation and Disease [Category] SARS, 진단, [키워드] BNT162b2 CD4 CD8 Cell Cell culture cellular cellular immunity Chemotherapy Combination Comorbidity coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 vaccination Donor donors dose Efficacy ENhance evaluated Ex vivo ex vivo expansion generate healthy humoral Humoral immunity Humoral response immunodeficiency Immunotherapy Infection investigated mononuclear cell mRNA Patient PBMC PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells powerful tool proportion proportions protective role protocol rapid expansion reactive REP Respiratory Coronavirus Result SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 spike glycoprotein spike glycoprotein‐reactive suppressed T cell T cells tested the vaccine vaccination Vaccine [DOI] 10.1002/iid3.496 PMC 바로가기 [Article Type] Original Article
Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through ‘reverse phenotyping’단일 세포 RNA 시퀀싱은 '역 표현형'을 통해 SARS-CoV-2 반응성 T 세포의 생체 외 서명을 밝힙니다.Article Published on 2021-07-262022-09-10 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] absence activated Activation acute respiratory syndrome Antigen antigenic antigenic stimulation approach cellular cellular immunity characterisation cohorts Conventional coronavirus disease Coronavirus disease 2019 correspondence COVID-19 detect Ex vivo high resolution human leukocyte antigen identify immune response in vitro in vivo independent induce Infection introduced leukocyte Patient patients phenotype Phenotypes phenotypic phenotypic effect powerful tool presence or absence provide reactive respiratory respiratory tract reveal RNA sequencing SARS-CoV-2 sequence sequences Severe acute respiratory syndrome severe disease Single Cell Single-cell RNA sequencing Stimulation T cell T cell receptor T cell response T cells T-cell receptor TCR TCRs the SARS-CoV-2 tissue tissues transcriptional viral infection virus [DOI] 10.1038/s41467-021-24730-4 PMC 바로가기 [Article Type] Article
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients신장 이식 환자에서 SARS-CoV-2 BNT162b2(토지나메란) 프라임-부스트 백신 접종 후 체액 및 세포 면역 손상Article Published on 2021-07-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] accompanied Adaptive immunity Affect age analyzed antibody approach BNT162b2 booster caused CD4+ CD8+ T cell cellular immunity cellular response change combating Control COVID-19 cytokine production dialysis dose Frequency global pandemic healthy healthy control Hemodialysis humoral IgA IgG immune immunization immunology immunosuppressed patients Immunosuppressive medication Impaired impairment individual kidney transplant recipient less majority memory mounted mRNA-based vaccine novel organ transplantation Patient patients powerful tool promotion reduced rejection renal response responses risk SARS-CoV-2 SARS-CoV-2 BNT162b2 second vaccination Seroconversion severe COVID-19 significantly Still T cells T helper cell transplantation undetectable vaccination Vaccine-induced immunity vaccinee [DOI] 10.1172/JCI150175 PMC 바로가기 [Article Type] Article
Potential activity of Linezolid against SARS-CoV-2 using electronic and molecular docking study전자 및 분자 도킹 연구를 사용한 SARS-CoV-2에 대한 Linezolid의 잠재적 활성Article Published on 2021-07-082022-09-11 Journal: Journal of molecular modeling [Category] SARS, 치료제, [키워드] absence ACE2 Analysis attenuation binding energy biological activity complexes COVID-19 develop docking domain drug ECD effective enzyme Evolution expected faster fluorine global pandemic indicated Interaction intermolecular interactions Linezolid medication Model Modification Mol molecular docking PDB performed positive Potential powerful tool RBD Receptor-binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike protein Schulz Scientific community Spike protein syndrome theory Therapies was performed [DOI] 10.1007/s00894-021-04828-8 PMC 바로가기 [Article Type] Article
Exploring Feasibility of Multivariate Deep Learning Models in Predicting COVID-19 EpidemicPublic Health Published on 2021-07-052022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] approach China complement complex COVID-19 COVID-19 epidemic Critical data-driven dataset death deaths deep deep learning develop Epidemic epidemiological feasibility hospital Hospitalization lack learning mathematical model mechanism memory Model modeling multivariate pandemic patients powerful tool predict press processed Release retrieved searched variable [DOI] 10.3389/fpubh.2021.661615 PMC 바로가기 [Article Type] Public Health