Is It Possible to Have Home E-Monitoring of Pulmonary Function in Our Patients with Duchenne Muscular Dystrophy in the COVID-19 Pandemic?—A One Center Pilot StudyObservational Study Published on 2021-08-262022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] age AioCare Anthropometric data applied asked benefit BMI Care center clinical collected conducted COVID-19 COVID-19 pandemic Digital health disease DMD Duchenne muscular dystrophy duration of life e-monitoring of pulmonary function enrolled European evaluated expiratory function FVC Germany Health home home monitoring home monitoring pulmonary function hospital introduced lack Lung function material mean value medical history MONITOR muscular no significant difference Patient performed Poland preserved professional Prospective Study protocol pulmonary Pulmonary function Pulmonary function test rare diseases reason recruited respiratory Satisfaction seeking SMS Society spirometry Support the mean the patient university Volume was performed [DOI] 10.3390/ijerph18178967 PMC 바로가기 [Article Type] Observational Study
Normal Adrenal and Thyroid Function in Patients Who Survive COVID-19 InfectionObservational Study Published on 2021-08-192022-10-04 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] SARS, 임상, [키워드] accounted ACE2 receptor acute COVID-19 acute illness Adrenal adrenal function Adrenal insufficiency age alteration assessment basal baseline cellular clinical care Clinical research college Context COVID-19 COVID-19 pandemic Dexamethasone diagnosis of COVID-19 disease severity Effect endocrine system evaluate Express facility fatigue function Health services implication NHS no difference normal not differ objective participant Patient performed preserved proportion Research Result SARS-CoV-2 serum study visit Survivors Symptom Symptoms the SARS-CoV-2 Thyroid thyroid function Thyroid function tests thyroid gland Treatment Trust virion while with COVID-19 [DOI] 10.1210/clinem/dgab349 PMC 바로가기 [Article Type] Observational Study
Predictors of Hypoxemia and Related Adverse Outcomes in Patients Hospitalized with COVID-19: A Double-Center Retrospective StudyArticle Published on 2021-08-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Adverse adverse outcome analyzed Blood oxygen saturation BMI body mass index body surface area BSA Comorbidities coronavirus disease COVID-19 CRP D-dimer level decrease determine elevated had more hallmark heart failure hospital Hospitalization hospitalized patient Hypoxemia in-hospital mortality independent predictor Jerusalem liver enzymes Lymphocyte count lymphocyte counts management multivariable obesity Odds ratio Older Older age outcome oxygen saturation patients hospitalized predictor predictors preserved Protein reduced regression analysis renal dysfunction renal function risk stratification severity significantly ventilatory support with COVID-19 [DOI] 10.3390/jcm10163581 PMC 바로가기 [Article Type] Article
Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat spike protein RBD protects mice against COVID-19Research Article Published on 2021-08-122022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Adenovirus Adenovirus-vectored vaccine administration antibody Antibody Response approved Bronchoalveolar lavage fluid cellular immune responses circulating variants COVID-19 COVID-19 pandemic COVID-19 vaccine delta variant dimeric domain effective elicit expressing humoral immune response Immunity immunogenic intramuscular intranasal route lung Lung injury mice mucosal Neutralizing activity preserved PROTECT Protein RBD recombinant recombinant chimpanzee adenovirus RNA Safe SARS-CoV-2 sera spike protein RBD Support undetectable vaccination Vaccine [DOI] 10.1080/22221751.2021.1959270 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoidsResearch Published on 2021-08-052022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abietane diterpenes: Molecular docking ACE2 ACE2 binding African binding binding free energy catalytic Clustering analysis COVID-19 pandemic docked docking drug drug-likeness eight Entry inhibitor first stage hotspot human Angiotensin-converting enzyme in silico in vitro in vivo inhibiting inhibitory Interaction interactions MD simulation MERS-CoV molecular molecular docking analysis pentacyclic performed plant preserved protease Protein protein targets Proteins provide residue Result S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 spike protein screened serine 2 Spike protein stability supplementary material targeting targets terpenoids the RBD the SARS-CoV-2 therapeutic strategy TMPRSS2 trajectory transmembrane viral cell [DOI] 10.1186/s43141-021-00209-z PMC 바로가기 [Article Type] Research
COVID-19 deep classification network based on convolution and deconvolution local enhancement컨볼루션 및 디컨볼루션 로컬 향상을 기반으로 하는 COVID-19 심층 분류 네트워크Article Published on 2021-08-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] abdominal cavity Accuracy Algorithm asymptomatic infections collected Complete computer Convolution Corona Coronavirus pneumonia COVID-19 COVID-19 classification network dataset Deconvolution determine Diagnosis Diego disease enhanced Enhanced CT features enhanced image feature IMPROVE infection rate infections Local Negative predictive value network model Novel coronavirus novel coronavirus pneumonia NPV overcome Patient patients with asymptomatic Pneumonia positive Positive predictive value PPV Precision Predictive value preserved Prevalence prevalence rate problem problems provided region of interest researcher ROI ROI extraction. sensitivity significant difference specificity University of California Virus Disease [DOI] 10.1016/j.compbiomed.2021.104588 PMC 바로가기 [Article Type] Article
Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection염증의 내인성 조절은 무증상 또는 무증상 SARS-CoV-2 감염이 있는 임산부의 특징입니다.Article Published on 2021-07-292022-09-10 Journal: Nature Communications [Category] SARS, 바이오마커, [키워드] Activation Affect alteration anti-inflammatory cytokine anti-inflammatory cytokines antiviral immune response antiviral immune responses Asymptomatic Blood cells cell proliferation cytokine cytokine production Cytokines cytometry analysis D-dimer damages develop differentiation during pregnancy endogenous help heterogenous IL-10 IL-17 IL-6 Immune cell immune responses immunological change immunological changes increase in Inflammation Inflammatory interleukin lymphopenia marker mild SARS-CoV-2 infection mother neutrophil Neutrophils PD-L1 Peripheral blood plasma Plasma levels Pregnancy pregnant women preserved pro-inflammatory cytokines remain unchanged reported SARS-COV-2 infection Therapeutic strategies therapeutic strategy therapeutic target Translational immunology viral infection virus White blood cells [DOI] 10.1038/s41467-021-24940-w PMC 바로가기 [Article Type] Article
Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDSObservational Study Published on 2021-07-282022-10-04 Journal: Critical Care [Category] 임상, [키워드] 95% CI acute respiratory distress Analysis ARDS association caused collected Complete Compliance coronavirus disease COVID-19 COVID-19 adult patient COVID-19 patient criteria death described died driving Driving pressure enrolled feature greater higher odd Hypoxemia ICU indicated intensive care Intubated linear Logistic regression analysis mechanical ventilation Mortality multicenter cohort study normalized Patient patients preserved reduce Respiratory system Respiratory system compliance Result risk of death screened significant increase Static static compliance supplementary material syndrome Volume [DOI] 10.1186/s13054-021-03667-6 PMC 바로가기 [Article Type] Observational Study
Assessment of Ventilation and Perfusion in Patients with COVID-19 Discloses Unique Information of Pulmonary Function to a Clinician: Case Reports of V/P SPECTCase Report Published on 2021-07-202022-10-31 Journal: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine [Category] COVID-19, [키워드] assessment consecutive patient COVID-19 dead detect diagnose function induce Inflammation lung Perfusion preserved pulmonary Pulmonary embolism pulmonary inflammation report reversed SARS-CoV-2 severe hypoxemia Shunt SPECT vasculature Ventilated Ventilation ventilation/perfusion with COVID-19 [DOI] 10.1177/11795484211030159 PMC 바로가기 [Article Type] Case Report
Cell Analysis from Dried Blood Spots: New Opportunities in Immunology, Hematology, and Infectious DiseasesResearch Article Published on 2021-07-182022-10-28 Journal: Advanced Science [Category] COVID-19, SARS, [키워드] analyses Analysis Biomarker Biomedical research Blood blood cell buffer CD169 Cell cells cellular compartments cellular molecule common coronavirus 2 Cytometry degrade described Dried blood spots elution buffer facilitate Flow healthcare hematology implication Infection Infectious disease Laboratory leucocyte majority management mRNA mRNA expression New opportunity Patient performed permeabilized preserved Rapid red blood cell resource respiratory SARS‐CoV‐2 shaking staining Support temperature variety while [DOI] 10.1002/advs.202100323 PMC 바로가기 [Article Type] Research Article