pro-inflammatory cytokine – Page 9 – Communicable Diseases Research

The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2

Review

Published on 2021-12-022022-10-30
Journal: Medicina [Category] COVID-19, SARS,

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.

Article

Published on 2021-12-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

SARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.

Article

Published on 2021-12-012022-09-11
Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘,

[키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased
[DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article

Pro-inflammatory CXCL-10, TNF-α, IL-1β, and IL-6: biomarkers of SARS-CoV-2 infection

전염증성 CXCL-10, TNF-α, IL-1β 및 IL-6: SARS-CoV-2 감염의 바이오마커

Article

Published on 2021-12-012022-09-11
Journal: Archives of Virology [Category] 바이오마커,

[키워드] antiviral cytokine antiviral cytokines Asymptomatic Biomarker Biomarkers categories category caused chemokine chemokines city clinical manifestation clinical manifestations controls CXCL-10 CXCL10 cytokine cytokine production Cytokines disease early phase except for excessive cytokine production Factor Hospitalized IFN-γ IL-12 IL-17 IL-1β IL-4 IL-6 immune system India individual infected patients Infection infiltration inflammatory cells investigated Level Luminex platform mildly symptomatic patient mildly symptomatic patients morbidity morbidity and mortality no difference Novel coronavirus novel coronavirus SARS-CoV-2 outcome pandemic of COVID-19 Patient Plasma cytokine Postinfection pro-inflammatory cytokine pro-inflammatory cytokines recovered patient recovered patients reduced SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2-infected patient significantly higher significantly lower symptomatic the patient TNF-α uninfected control VEGF Viral viral infections virus replication
[DOI] 10.1007/s00705-021-05247-z PMC 바로가기 [Article Type] Article

Immature Platelets and Disease Severity in Patients Hospitalized with Acute COVID-19 Who Are Vaccinated Against COVID-19

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] acute COVID-19 Admission Against age Analysis analyzed approved benefit Biomarker Care chronic obstructive Cohort conducted contagious correlated covariate COVID-19 COVID-19 patient COVID-19 vaccine Critical database death demonstrated Dexamethasone download elevated figure fraction future infection Gender Health Hispanic patient hospital Hospital stay Hospitalization Hospitalized hospitalized patient Hypothesis ICU ICU admission immature in-hospital mortality independent Inflammatory response initial institutional review board IPF knowledge lack Lancet LOS mechanical ventilation Mortality mRNA COVID-19 vaccine NEJM non-ICU patient non-ICU patients non-parametric test not correlated outcome outcomes pathophysiology Patient patient data patient population patients Platelet Polack pre-vaccination predict Predictive pro-inflammatory cytokine prognostic biomarker progression Protective pulmonary disease randomized trial reported required Research resource severe COVID-19 severity significantly lower significantly shorter Spearman strained Support table thrombotic event University of Texa vaccinated against COVID-19 variant ventilator Welder
[DOI] 10.1182/blood-2021-146790 [Article Type] Conference abstract

Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate

Research Article

Published on 2021-11-232022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS, SARS,

Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

Immunology

Published on 2021-11-192022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

Research Article

Published on 2021-11-182022-10-28
Journal: PLoS ONE [Category] COVID-19,

[키워드] ACE2 angiotensin-converting enzyme 2 antibodies Antiviral antiviral activity approach binding binding affinity cell entry Contact crystal structure demonstrated Effect experiment expressing glycoprotein high affinity host cell human cell Inflammation inhibiting inhibitor Interaction linear majority membrane nanobody neutralisation assay peptide peptides pro-inflammatory cytokine RBM Receptor binding domain receptor binding motif residue responsible S RBD SARS-CoV-2 SARS-CoV-2 viral selected sequence soluble ACE2 Spike protein suggested suppress the S1 subunit the SARS-CoV-2 the spike protein to define trimer viral cell viral spike viral spike protein virulence
[DOI] 10.1371/journal.pone.0260283 PMC 바로가기 [Article Type] Research Article

An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants

SARS-COV-2 감염에 대한 TLR의 반응에 대한 최근의 통찰력과 SARS-COV-2 백신 보조제로서 TLR 작용제의 잠재력에 대한 개요

Review

Published on 2021-11-182022-08-31
Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity addition adjuvant adjuvants agonist approach chemokine coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines Critical cytokine death Defense downstream dysregulated Efficacy ENhance focus Health Host host defense host innate immunity human disease immune responses Immune-mediated Immunity Immunopathogenesis initial innate immune response innate immune system Innate immunity insight Interaction invading pathogen invading pathogens pandemic pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogens pathology Potential pro-inflammatory cytokine recent recognize respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shaping Signaling therapeutic TLR TLR agonist TLR agonists TLR response TLRs Toll-like receptor Toll-like receptors Vaccine
[DOI] 10.3390/v13112302 PMC 바로가기 [Article Type] Review

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms

Curcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다

Article

Published on 2021-11-162022-09-10
Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used
[DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article