Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies자연적으로 유도된 항-SARS-CoV-2 항체에 의한 SARS-CoV-2 중화의 구조적 유연성Article Published on 2022-08-052022-09-11 Journal: Communications Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding site Alpha anti-RBD anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Arm array Beta bind binding conformations convalescent Cross linking cross-neutralizing Culture Delta Donor elicited epitope evaluate exhibit FIVE flexible Gamma likelihood mAb mAbs mechanism molecular monoclonal antibodies monoclonal antibody mutated neutralization neutralize Neutralizing nine omicron Proteins provide pseudoviruses RBD Receptor binding domain recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer SARS-CoV-2 variants Spike protein Spike proteins spike trimer Structure structures subunits tested the RBD the SARS-CoV-2 unique variant variants of concern variants of SARS-CoV-2 Viral viral evolution virus viruses VoC VOCs wild type Wuhan-Hu-1 [DOI] 10.1038/s42003-022-03739-5 PMC 바로가기 [Article Type] Article
The influence of new SARS-CoV-2 variant Omicron (B.1.1.529) on vaccine efficacy, its correlation to Delta variants: A computational approach새로운 SARS-CoV-2 변이체 Omicron(B.1.1.529)이 백신 효능에 미치는 영향, Delta 변이체와의 상관관계: 전산적 접근Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Analysis antibody approach AY.1 B.1.1.529 binding affinity caused computational analysis correlation COVID CR3022 Delta Delta variants docking docking analysis domain Effect Efficacy Host hosts human ACE2 receptor human monoclonal antibodies Human monoclonal antibody immune evasion in silico Approach In-silico analysis Interaction lead MD simulation Modification Mutation neutralizing antibody new SARS-CoV-2 omicron Omicron variant pathogenicity promote Proteins RBD RBD variant Reinfection SARS-CoV-2 variant Spike proteins Strains Structure the binding affinity the WHO Vaccine variant [DOI] 10.1016/j.micpath.2022.105619 PMC 바로가기 [Article Type] Article
Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용Article Published on 2022-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, [키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database [DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literatureReview article Published on 2022-08-012022-10-05 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE addition affecting age article association CCR5 cellular protease Clinical outcome Comorbidities correlation COVID-19 COVID-19 severity Deletion evaluate expression finding Genetic Genetic predisposition genetic risk genetic susceptibility genetics help HLA haplotypes host genetics IFNs IFNλ immune system individual Mortality mutations polymorphism Polymorphisms Proteins reduced retrieved risk risk factor SARS-CoV-2 several gene severity severity of COVID-19 smoking susceptibility systematic review TLR TMPRSS2 TNF Treatment upregulation vaccination Variability with COVID-19 [DOI] 10.1016/j.gene.2022.146674 [Article Type] Review article
SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregationSARS-CoV-2는 스트레스 과립의 분해를 손상시키고 ALS 관련 아밀로이드 응집을 촉진합니다Article Published on 2022-08-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 addition aggregation bind Cell cells cellular clearance experiment FUS Host host cells impair in vitro incorporation increased risk indicate infect Infection interactions Invasion mammalian cell mammalian cells Mutation N protein neurodegeneration NMR non-specific nucleocapsid nucleocapsid protein occur phase transition promote Protein Proteins reported SARS-CoV-2 SARS-COV-2 infection scenario stimulated Stress stress granule stress granules [DOI] 10.1007/s13238-022-00905-7 PMC 바로가기 [Article Type] Article
Platelets in the NETworks interweaving inflammation and thrombosis염증과 혈전을 뒤섞는 NETworks의 혈소판Review Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] 치료기술, 치료제, [키워드] activate Bacterial Capillaries capillary characterized chemokine chemokines chromatin Clinical outcome Coagulation factors contribute contributing to Course COVID-19 COVID-19 pandemic COVID-19 patient Cytokine storm disease DNA engage ENhance Evidence expression Extracellular extracellular space Growth factors hemorrhage Hemostasis histone Histones host innate immunity immune response immunothrombosis IMPROVE increased mortality induce infiltration Inflammation Inflammatory diseases inflammatory signaling Interaction interface kill lesion lung majority mechanism microthrombi molecular mechanism NET NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil infiltration Neutrophils other tissue other tissues pathogen Pathogens Pathways Patient Pattern recognition Pattern recognition receptors Platelet Platelets procoagulant Protein Proteins provide provided resulting signaling pathway subsequent surface expression survival target thrombi thrombosis thrombotic TLR2 TLR4 Topic TRAP Treatment vascular beds virus [DOI] 10.3389/fimmu.2022.953129 PMC 바로가기 [Article Type] Review
TMED3 Complex Mediates ER Stress-Associated Secretion of CFTR, Pendrin, and SARS-CoV-2 SpikeTMED3 복합체는 CFTR, Pendrin 및 SARS-CoV-2 스파이크의 ER 스트레스 관련 분비를 매개합니다Article Published on 2022-08-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis CFTR complex conditions Critical cystic fibrosis ER stress Evidence expression fibrosis gene silencing improves involved mechanism membrane protein Membrane proteins pathway pendrin pendrin. plasma membrane Protein Proteins recognize reduce reduces SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral secretion spike syndrome TMED TMED10 TMED2 TMED3 TMED9 transmembrane transmembrane protein Transport UPS [DOI] 10.1002/advs.202105320 PMC 바로가기 [Article Type] Article
Computational repurposing approach for targeting the critical spike mutations in B.1.617.2 (delta), AY.1 (delta plus) and C.37 (lambda) SARS-CoV-2 variants using exhaustive structure-based virtual screening, molecular dynamic simulations and MM-PBSA methods철저한 구조 기반 가상 스크리닝, 분자 역학 시뮬레이션을 사용하여 B.1.617.2(델타), AY.1(델타 플러스) 및 C.37(람다) SARS-CoV-2 변이체에서 중요한 스파이크 돌연변이를 타겟팅하기 위한 전산 용도 변경 접근 방식 및 MM-PBSA 방법Article Published on 2022-08-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] ACE-2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin-converting enzyme 2 approach Area atovaquone AY.1 B.1.617.2 binding affinity binding site candidate causative agent complex complexes Compound contagious contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Delta delta variant Delta variants docking result docking results drug Drug repurposing drug-likeness drugs eight enzyme FDA approved drug FDA approved Drugs followed by genomic help heparin highest binding affinity Host hydrogen Hydrogen bond identify in silico inhibiting inhibitor inhibitors interact Interaction interactions Lambda Ligand MD simulation MD simulations molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics morbidity and mortality mortality rates Mutation mutations Praziquantel Protein Proteins RBD Receptor-binding domain reported Research researcher residue SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simulation spike spike mutation Spike protein stability surface surface area targets the receptor-binding domain the spike protein variant variants variants of concern viral cell Virtual screening VoC was done was performed wild type Wuhan Wuhan, China [DOI] 10.1016/j.compbiomed.2022.105709 PMC 바로가기 [Article Type] Article
Dysregulation of Protein S in COVID-19Review article Published on 2022-08-012022-10-05 Journal: Best Practice & Research Clinical Haematology [Category] 진단, [키워드] Acquired Activation Anticoagulant binding C4b-binding protein caused clearance Coagulation complement COVID-19 COVID-19 patients deficiency Degradation Efferocytosis Evidence function Inflammatory mechanism mechanisms multiple study Patient plasma plasma protein potential mechanism Protein protein S Protein S deficiency Proteins regulate reported TAM receptors thrombosis thrombotic risk viral infection [DOI] 10.1016/j.beha.2022.101376 [Article Type] Review article