SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavageArticle Published on 2021-08-042023-06-16 Journal: The EMBO Journal [Category] MERS, SARS, [키워드] Autophagy & Cell Death GSDMD Inflammasome Microbiology, Virology & Host Pathogen Interaction nucleocapsid pyroptosis SARS‐CoV‐2 [DOI] 10.15252/embj.2021108249 PMC 바로가기 [Article Type] Article
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 may trigger inflammasome and pyroptosis in the central nervous system: a mechanistic view of neurotropismReview Published on 2021-07-092023-06-16 Journal: Inflammopharmacology [Category] MERS, SARS, [키워드] Inflammasome neurotropism pro-inflammatory cytokines pyroptosis SARS-CoV-2 [DOI] 10.1007/s10787-021-00845-4 PMC 바로가기 [Article Type] Review
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and ThromboembolismImmunology Published on 2021-06-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 48 hour ACE2 ANPEP Apoptosis Autoimmune disease cancers cardiovascular comorbidity cardiovascular disease CEACAM1 cell death changes in complexes contribute controls coronavirus Coronavirus infection Coronaviruses COVID-19 CSF1 CSF3 CVD Cytokine storms DAMP DAMPs dataset death DPP4 Endothelial cell enzyme Epigenetic ER stress examined Express expressed expression facilitate Factor Ferroptosis hours post-infection Human hyperlipidemia IL6 Immunity Inflammation innate immune innate immune responses LPS majority marker MERS-CoV Microarray mitochondrial mitotic modulated monocyte Myelopoiesis Nrf2 nucleic acid oxidative phosphorylation PAMP Proinflammatory cytokine Proinflammatory response protein complex pyroptosis receptor regulate ROS stimulated Stimulation storm Stress subsequent Thromboembolism thrombosis TMPRSS2 TNFα trained immunity transcriptomic upregulated upregulation Viremia virus entry [DOI] 10.3389/fimmu.2021.653110 PMC 바로가기 [Article Type] Immunology
Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19Review Published on 2021-06-232022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Apoptosis caused cell death cells chemokines circulating Concentration coronavirus coronavirus disease COVID-19 COVID-19 patients cytokine Cytokine storm death deleterious effect dysregulation feature healthy hypothese Immune cell immune cells Immunopathogenesis knowledge maintain mechanism monocytopenia necroptosis occur pathway pyroptosis raised reduction role SARS-CoV-2 specific type the disease Therapeutic strategies viral infections virus entry [DOI] 10.3390/cells10071585 PMC 바로가기 [Article Type] Review
Release mechanisms of major DAMPs주요 DAMP의 방출 메커니즘Review Published on 2021-03-132022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] Activation addition anti-DAMP strategies Apoptosis ATP Cancer Cell cell death cell membrane cell-free DNA channel pores contribute Damage-associated molecular patterns DAMP DAMP release DAMP-specific mechanism DAMPs disorder disorders ectosomes effective endogenous molecule endogenous molecules Exocytosis Exosome Exosomes Extracellular extracellular cold-inducible RNA-binding protein extracellular RNA extracellular RNAs Ferroptosis focus foment heat shock proteins Histones Inflammation inflammatory mediator Inflammatory mediators live cell live cells Lysosomes mechanism mechanisms of release mediators membrane rupture molecular pattern necroptosis Necrosis NETosis Other Protein pyroptosis Release released reported secretory lysosome secretory lysosomes Sepsis tissues [DOI] 10.1007/s10495-021-01663-3 PMC 바로가기 [Article Type] Review
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytesArticle Published on 2021-03-012022-10-04 Journal: Cell Death Discovery [Category] 치료제, [키워드] 2019 coronavirus disease Activation acute respiratory syndrome caspase-1 cellular component cleavage coronavirus COVID-19 critically ill patients death engage gasdermin D human monocytes hyper-inflammation IL-1ß Inflammasome Inflammatory response intensive care leukopenia mechanism monocyte Monocytes Patient Peripheral blood pro-inflammatory cytokine pyroptosis recruited reduce viral replication respiratory tract SARS-CoV-2 severe COVID-19 therapy Trigger viral infection [DOI] 10.1038/s41420-021-00428-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeuticsSARS-CoV-2 감염: 치료법을 제안하는 심각한 결과의 분자 메커니즘Review Published on 2021-02-012022-09-11 Journal: Expert review of proteomics [Category] MERS, 유전자 메커니즘, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome. ARDS Area base pair base pairs Biomarker Biomarkers Clinical course clinical risk factor Clinical risk factors Combination COVID-19 cytokine cytokine signaling dataset datasets defined door drug endotheliopathy expert genetics Google Scholar Human Impact infect Infection literature MODS molecular molecular mechanism multiple organ dysfunction multiple organ dysfunction syndrome NCBI NETosis opens organ dysfunction syndrome outcome pathology pathway Patient patients with COVID-19 Pneumonia positive feedback positive feedback loop Precision pyroptosis respiratory distress Respiratory distress syndrome Risk factors RNA SARS-CoV-2 SARS-CoV-2 genome secondary infections severe COVID-19 SRA Support syndrome tested the SARS-CoV-2 genome therapeutic Therapeutics thrombocytopathy treat Treatment Treatment strategies treatment strategy understanding unique [DOI] 10.1080/14789450.2021.1908894 PMC 바로가기 [Article Type] Review
Cannabinoids as Key Regulators of Inflammasome Signaling: A Current PerspectiveInflammasome 신호 전달의 주요 조절자로서의 칸나비노이드: 현재의 관점Review Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, 치료제, [키워드] activated Anti-inflammatory cannabidiol cannabinoid cannabinoids cannabis caspase caspase-1 chronic inflammatory diseases chronic inflammatory disorder chronic inflammatory disorders concerning coronavirus coronavirus disease COVID-19 current Cytokines cytoplasmic Delta-9 tetrahydrocannabinol detect drug elements etiology Evidence human disease human diseases human disorder IL-18 indicate Inflammasome inflammasome activation inflammasome signaling inflammasomes Inflammatory Inflammatory diseases inflammatory disorders inflammatory signaling ingredient Innate immunity interleukin marijuana maturation mechanism Medical conditions microbial milieu modulating pandemic pathophysiology plant pro-inflammatory cytokines promote protein complex protein complexes pyroptosis referred to Regulation regulator Research secretion Support tetrahydrocannabinol Treatment variety [DOI] 10.3389/fimmu.2020.613613 PMC 바로가기 [Article Type] Review
Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 InfectionInflammasome 및 Pyroptosis 경로의 주요 구성 요소는 송곳니와 고양이에서 결핍되어 SARS-CoV-2 감염에 대한 반응에 영향을 미칠 수 있습니다Immunology Published on 2021-01-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] Activation activation of inflammasome AIM2 canine canines cats cause Comparative genomics component COVID-19 pandemic cytokine Cytokine storm deficiencies deficiency Deficient dog Excessive activation felines genomics study GSDMB GSDME Host infected with SARS-CoV-2 Infection Inflammasome mechanism Mild Mild symptom mild symptoms natural NLRC4 NLRP1 pathway performed pyroptosis reducing response SARS-CoV-2 SARS-COV-2 infection Severe Acute Respiratory Syndrome Corona Virus 2 Symptom Trigger [DOI] 10.3389/fimmu.2020.592622 PMC 바로가기 [Article Type] Immunology