Personalized treatment supported by automated quantitative fluid analysis in active neovascular age-related macular degeneration (nAMD)—a phase III, prospective, multicentre, randomized study: design and methods Research Published on 2022-07-052022-10-05 Journal: Eye (London, England) [Category] 바이오마커, [키워드] 1:1 absence Age-related macular degeneration Analysis artificial intelligence assessments automated benefit Biomarker Care change clinical trial clinician defined disease Disease activity ENhance healthcare providers Hypothesis implementation injection investigator IRF less management multicentre offer Optical coherence tomography outcome Patient patient safety point-of-care Primary outcome protocol quantification Quantitative Randomized secondary outcome SRF subretinal fluid supported the mean therapeutic decisions therapy treated Treatment Variability Volume [DOI] 10.1038/s41433-022-02154-8 [Article Type] Research
Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection경증 감염 후 소아 및 성인의 SARS-CoV-2 감염에 대한 장기 면역 반응Article Published on 2022-07-012022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis anti-SARS-CoV-2 antibody Asymptomatic chemiluminescent immunoassay children clinic Cluster Cohort cohort study COVID-19 COVID-19 vaccination demonstrated Department enrolled Evidence family Follow-up follow-up time help IgG IgG titer immune response individual Infection Italian longitudinal median Mild Older older patient parent Patient pediatric persistence prospective cohort study provide quantification response S-RBD SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection significantly higher single-center spike receptor-binding domain study participant Study participants sustained understanding university Vaccination strategies [DOI] 10.1001/jamanetworkopen.2022.21616 PMC 바로가기 [Article Type] Article
Influence of SARS-CoV-2 inactivation by different chemical reagents on the humoral response evaluated in a murine model쥐 모델에서 평가된 체액 반응에 대한 다양한 화학 시약에 의한 SARS-CoV-2 비활성화의 영향Article Published on 2022-07-012022-09-12 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Administered anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antigen antigenic biosafety Brazil cell culture supernatant Cytopathic effect ELISA ELISA assay evaluate evaluated expressive formaldehyde glutaraldehyde highest humoral IgG immunization immunized immunogen inactivated Inactivated virus inactivation influence mice murine model Neutralizing neutralizing antibody observation pandemic plaque polymerase chain PRNT PRNT(50) protocol purified quantification reagent real time risk RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 viral subsequent Test the SARS-CoV-2 Toxicity Treatment verification Vero cells Viral antigen viral inactivation Viral protein virus was performed [DOI] 10.1016/j.molimm.2022.05.012 PMC 바로가기 [Article Type] Article
Detection and Stability of SARS-CoV-2 in Three Self-Collected Specimen Types: Flocked Midturbinate Swab (MTS) in Viral Transport Media, Foam MTS, and Saliva자체 수집한 3가지 표본 유형에서 SARS-CoV-2의 검출 및 안정성: 바이러스 수송 배지, 거품 MTS 및 타액의 무리를 이루는 중비갑개 면봉(MTS)Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ambient Analysis children cohorts collected Community Concordance conditions coronavirus COVID-19 detection evaluated exposure to facilitate feasible finding Foam illness illnesses in viral nucleocapsid Open reading frame ORF pandemic positive provided quantification reading respiratory respiratory specimens RT-PCR RT-PCR detection Saliva saliva samples saliva specimen saliva specimens sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 testing sensitivity severe acute respiratory syndrome Coronavirus specimen specimen collection spike stability Support Swab temperature tested Transport Transport media transported viral transport media VTM widespread [DOI] 10.1128/spectrum.01033-22 PMC 바로가기 [Article Type] Article
Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis항체 매개 신경 혈관 혈전증 동안 혈소판 및 호중구의 실시간 영상Article Published on 2022-06-282022-09-12 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activate acute respiratory syndrome adenoviral vector vaccine administration allergic disease analyses animal model approach Autoimmune Blood Brain can be used cellular cellular response complexes coronavirus disease downstream Endothelium event expressing immune complex Immune complexes implicated Infection interactions leukocyte medications mice Neurovascular neutrophil pathogenic Platelet Platelets quantification receptor rheumatological SARS-CoV-2 systemic disorder thrombosis thrombotic thrombotic complication transgene transgenic vasculature vessel walls [DOI] 10.1182/bloodadvances.2021006728 PMC 바로가기 [Article Type] Article
Saliva changes in composition associated to COVID-19: a preliminary studyCOVID-19와 관련된 타액 조성 변화: 예비 연구Article Published on 2022-06-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Activation ACTN4 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aggregation Anosmia antibody ANXA4 Asymptomatic CA6 can be used caused changes in clinical presentation Clinical presentations composed control group coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID 19 COVID-19 COVID-19 group diagnostic diagnostics disease Diseases downregulation dysgeusia FGB FIVE healthy healthy individual immune response involved Mild mild COVID-19 patient mild COVID-19 patients occur oxidative damage pathophysiology Patient patients patients with COVID-19 Perspective positive Potential biomarker potential biomarkers Protective Protein proteome proteomic study proteomics pulmonary tissue quantification respiratory complication Respiratory complications RT-PCR Saliva saliva samples salivary SARS-CoV 2 separated severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 stimulus taste perception tested TGM3 the disease tissue Treatment two groups upregulation variety viral infection virus [DOI] 10.1038/s41598-022-14830-6 PMC 바로가기 [Article Type] Article
Broadly Applicable, Virus-Free Dual Reporter Assay to Identify Compounds Interfering with Membrane Fusion: Performance for HSV-1 and SARS-CoV-2막 융합을 방해하는 화합물을 식별하기 위해 광범위하게 적용 가능한 바이러스 없는 이중 보고자 분석: HSV-1 및 SARS-CoV-2에 대한 성능Article Published on 2022-06-212022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] alkaline alkaline phosphatase antiviral agent Antiviral agents cell-cell fusion cell–cell fusion Compound doxycycline dual reporter assay Efficacy enzyme expressed expression fluorescent fusion inhibition HSV-1 identify inhibitors Internal control marker membrane fusion nanoluciferase nuclear Pathogens performance phosphatase quantification Replication reported reporter reporter fusion reporter gene SARS-CoV-2 secreted secreted alkaline phosphatase secreted nanoluciferase. Sensitivity and specificity Tetracycline transient transfection Vero Cell Vero cells viral pathogens was tested [DOI] 10.3390/v14071354 PMC 바로가기 [Article Type] Article
Rapid Quantification of SARS-Cov-2 Spike Protein Enhanced with a Machine Learning Technique Integrated in a Smart and Portable Immunosensor스마트하고 휴대용 면역 센서에 통합된 기계 학습 기술로 강화된 SARS-Cov-2 스파이크 단백질의 신속한 정량화Article Published on 2022-06-172022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 신종인플루엔자, 치료기술, [키워드] Accuracy addition Affect Algorithm Algorithms Analysis applicability Classifier COVID-19 Data processing demonstrated electrochemical immunosensor electrode enhanced evaluated Features gold Gold nanoparticles H1N1 hemagglutinin immobilization Influenza influenza A influenza A virus IoT-WiFi lentiviral machine machine learning medium Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus monoclonal antibodies monoclonal antibody nasopharyngeal swabs negative sample point of care point of care testing protocol pseudotyped quantification Rapid respiratory syndrome coronavirus S1 subunit SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein Screen SmaRT specificity spike spike glycoprotein Spike protein spike protein S1 Support technique tested the SARS-CoV-2 transfer virus detection [DOI] 10.3390/bios12060426 PMC 바로가기 [Article Type] Article
Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response중증 급성 호흡기 증후군 코로나바이러스 2 환자에서 전염증성 지질 매개체 및 전문 분해 분자의 혈청 수준이 증가하고 적응 면역 반응의 마커와 상관 관계가 있습니다Article Published on 2022-06-152022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anti-inflammatory Anti-nucleocapsid Anti-spike anti-spike antibody assays binding bioactive lipids Clinical outcome collected Concentration Control coronavirus coronavirus 2 died female hospital identify immune immune response Increased innate response Inpatient Level linoleic acid Lipid lipids male mediator molecule Omega pandemic pathogenic inflammation Pathways Patient patients positive correlation processed proinflammatory quantification Quantitative respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients serum Serum level serum levels severe acute respiratory syndrome Coronavirus Sex significantly higher significantly lower specialized proresolving molecules. symptomatic SARS-CoV-2 infection transition [DOI] 10.1093/infdis/jiab632 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes중환자 COVID-19 환자의 폐실에서 SARS-CoV-2 바이러스 부하가 바이러스 혈청 부하 및 치명적인 결과와 상관관계Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] association BAL Blood bronchoalveolar Bronchoalveolar lavage clinical Clinical data Clinical outcome clinical outcomes compartment contribute copy number correlation COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical care Critically ill Critically ill patient critically ill patients Croatia diagnostic disease elevated highest hospital ICU admission Ill intensive care intensive care unit load Lower respiratory tract lung Lungs mechanical ventilation support outcome outcomes pandemic parameter Predictive Prognostic value pulmonary qPCR quantification quantified SARS-CoV-2 SARS-CoV-2 detection serum sample serum samples sputum survival Swab swabs upper respiratory tract Viral load viral load analysis viral loads Virus quantification virus titers while [DOI] 10.3390/v14061292 PMC 바로가기 [Article Type] Article