Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques회복기 COVID-19 환자 및 RBD 나노입자 백신 히말라야 원숭이로부터 수집된 혈청에 의한 신규 돌연변이 B.1.1.7 및 501Y.V2를 중화하기 위한 차등 효율Article Published on 2021-04-012022-09-11 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V2 B.1.1.7 collected convalescent COVID-19 patient Efficiency mutant neutralize RBD rhesus macaque sera [DOI] 10.1038/s41423-021-00641-8 PMC 바로가기 [Article Type] Article
A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaquesShort communication Published on 2021-03-202022-10-05 Journal: Cell Reports Medicine [Category] 비임상, [키워드] ACE2 adenoviral vector Administered chimpanzee adenovirus-vectored vaccine coronavirus disease COVID-19 described disease dose Efficacy expressing human Angiotensin-converting enzyme humans Immunity immunized immunogenicity induce Infection intrabronchial intranasal intranasally limit Lower respiratory tract mice mucosal neutralizing antibody non-human primates pandemic pre-fusion Prevent PROTECT protection Protective Protein receptor required rhesus macaque SARS-CoV-2 SARS-COV-2 infection T cell response Transmission Vaccine [DOI] 10.1016/j.xcrm.2021.100230 [Article Type] Short communication
Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2IMMUNOLOGY Published on 2021-03-182022-10-30 Journal: National Science Review [Category] COVID-19, [키워드] in vivo protection ACE2 receptor adverse event antibody binding block cellular receptor characterized complex concentrations conformational change COVID-19 cryo-EM structure dose effective Fab Fab fragment Human monoclonal antibody human neutralizing antibody immuno-therapy Infection membrane fusion monoclonal antibody Mouse models occlude postfusion preclinical safety evaluation prefusion Prevent progression Receptor binding domain rhesus macaque SARS-CoV-2 single dose subsequent therapeutic trimeric [DOI] 10.1093/nsr/nwaa297 PMC 바로가기 [Article Type] IMMUNOLOGY
Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implicationsArticle Published on 2021-03-122022-10-04 Journal: Nature Communications [Category] SARS, 바이오마커, 치료기술, 치료법, [키워드] Affect alteration arginine association change chemokine Correlation analysis COVID-19 COVID-19 patient COVID-19 patients CRS cytokine cytokine release Cytokines Diseases Ex vivo healthy controls Host hyperinflammation IL-1α IL-1β IL-6 immune response implication Inflammatory response Injury M-CSF metabolic pathway metabolism metabolite metabolite analysis metabolomic metabolomics Mild modulate mononuclear cell outcome Peripheral blood Prognostic markers proinflammatory Proinflammatory cytokine purine Regulatory reveal rhesus macaque SARS-CoV-2 SARS-COV-2 infection serum sample severe COVID-19 patients stratified syndrome therapeutic therapeutic target [DOI] 10.1038/s41467-021-21907-9 PMC 바로가기 [Article Type] Article
Coronavirus-Specific Antibody Cross Reactivity in Rhesus Macaques following SARS-CoV-2 Vaccination and InfectionVaccines and Antiviral Agents Published on 2021-03-102022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] 229E acute respiratory syndrome Antibody Response Betacoronavirus binding common cold coronavirus CoV CoVs cross-react cross-reactive cross-reactivity DNA expressing facilitate full-length spike protein highlight HKU1 Humoral immunity immunization implication induce Infection macaque Neutralizing Neutralizing antibodies Neutralizing antibody response NHPs NL63 observation OC43 other coronavirus other coronaviruses pandemic polyclonal profile pseudoviruses RBD reactivity Receptor binding domain response rhesus macaque rhesus macaques robust sarbecovirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum similarity Spike protein Spike proteins the SARS-CoV-2 the vaccine vaccination Vaccine Vaccines was reduced [DOI] 10.1128/JVI.00117-21 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaquesArticle Published on 2021-03-022022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] Administered affected alveolar epithelium Bronchoalveolar lavage fluid Candidates clearance clinical development clinical trial COVID-19 pandemic days post-infection develop effective vaccine Efficacy exhibited FIVE four group groups Health histopathological IgG immunized immunogenicity immunohistochemistry inactivated Inactivated Vaccines India interstitial pneumonia lung tissue macaque Macrophage nasal swab Neutralizing antibody titer no evidence of overcome pandemic phase Placebo Pneumonia Preclinical research Protective public health rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine second dose the placebo group the vaccine three group throat swab Vaccine vaccine candidate Viral antigen viral infection [DOI] 10.1038/s41467-021-21639-w PMC 바로가기 [Article Type] Article
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques새로운 DNA 및 단백질 조합 COVID-19 백신 제형은 붉은털 원숭이에서 SARS-CoV-2에 대한 완전한 보호를 제공합니다Coronaviruses Published on 2021-03-012022-09-12 Journal: Emerging Microbes & Infections [Category] SARS, 진단, [키워드] animal models approach B cell Cell Combination component COVID-19 vaccine Critical develop DNA DNA vaccine effective elicited full-length immune response immunized immunogenic memory B neutralizing antibody non-human primate Protein protein vaccine provide Recombinant S1 protein responses rhesus macaque rhesus macaques Safe SARS-CoV-2 SARS-CoV-2 virus significantly spike spike glycoprotein T cell Vaccine [DOI] 10.1080/22221751.2021.1887767 PMC 바로가기 [Article Type] Coronaviruses
Development of a reverse transcription droplet digital PCR (RT-ddPCR) assay for sensitive detection of simian immunodeficiency virus (SIV)Methodology Published on 2021-02-152022-10-28 Journal: Virology Journal [Category] COVID-19, [키워드] Cell Combination condition Critical development digital PCR HIV HIV cure research human HIV immunodeficiency virus Infection Intervention priming quantification Raindance Research Result reverse transcriptases reverse transcription rhesus macaque RNA RNA samples RT-ddPCR sensitive Simian simian immunodeficiency virus SIV supplementary material target therapeutic tissue sample treatment regimen Viral reservoir [DOI] 10.1186/s12985-021-01503-5 PMC 바로가기 [Article Type] Methodology
BNT162b vaccines protect rhesus macaques from SARS-CoV-2 Research Published on 2021-02-012022-10-05 Journal: Nature [Category] SARS, 비임상, 유전자 메커니즘, [키워드] Antibody Response BNT162b BNT162b1 BNT162b2 candidate candidate vaccine CD4+ COVID-19 disease domain dose dose-dependent effective elicit ENCODE evaluated Evidence full-length geometric mean titre Germany human ACE2 human sera immunize immunogen intramuscular Lipid nanoparticles Lower respiratory tract macaque Messenger RNA mice Phase I populations prefusion conformation proline PROTECT RBD residue rhesus macaque S glycoprotein Safe SARS-CoV-2 secreted spike glycoprotein T cell responses titre transmembrane Trial trimer vaccination Vaccine vaccine candidate Viral RNA [DOI] 10.1038/s41586-021-03275-y [Article Type] Research