Knowledge and Attitudes Toward Covid-19 and Vaccines Among a New York Haredi-Orthodox Jewish Community뉴욕 Haredi-Orthodox 유대교 공동체의 Covid-19 및 백신에 대한 지식과 태도Observational Study Published on 2021-12-012022-09-11 Journal: Journal of community health [Category] SARS, 변종, 임상, [키워드] 95% CI 95% confidence interval adjusted odds ratio Antibody test Attitude Brooklyn Community conducted COVID-19 COVID-19 pandemic COVID-19 vaccine cross-sectional difficulty examined group Health health information Immunity impacted independent predictors individual Infection information morbidity morbidity and mortality naïve individuals natural immunity natural infection New York observational study organizations Orthodox Jewish pandemic paper participant path physician Physicians positive predictor provide public health question reported Research respond risk SARS-CoV-2 viral subpopulations survey Transmission Trust unique vaccination Vaccine Vaccine hesitancy Vaccines variants [DOI] 10.1007/s10900-021-00995-0 PMC 바로가기 [Article Type] Observational Study
Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial SourcesReview Published on 2021-11-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3-chymotrypsin-like protease 3CLpro Antiviral Bacteria candidate caused Community Compound coronavirus 2 COVID-19 COVID-19 pandemic cysteine protease drug drug design drug target expand function fungi Health HIV protease inhibitor Host Infection information inhibitor inhibitors less microbial Modification nucleic acids nucleosides nucleotides Papain-like protease platform PLPro Potential protease Proteases Protein protein synthesis reported researcher resource respiratory RNA SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 proteases SARS-CoV-2 viral SARS-CoV2 Source Spread structures suggested the SARS-CoV-2 Transcription translation Treatment urgency virus virus replication while with COVID-19 [DOI] 10.3390/microorganisms9122481 PMC 바로가기 [Article Type] Review
Sex-Specific Microglial Activation and SARS-CoV-2 Receptor Expression Induced by Chronic Unpredictable StressNeuroscience Published on 2021-11-242022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] angiotensin-converting enzyme 2 Anxiety Brain changes in chronic chronic unpredictable mild stress coronavirus disease COVID-19 detrimental effect disorders Effect Evidence exacerbate expression female General population glial cells globe Immune homeostasis induced infected patient male MHCII mice microglia Mild monocyte mRNA level Neuroinflammation Neuropsychiatric neuropsychiatric disorders NRP1 pandemic provided receptor receptors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral SARS-CoV2 Stress susceptibility susceptible the SARS-CoV-2 upregulated Withdrawal [DOI] 10.3389/fncel.2021.750373 PMC 바로가기 [Article Type] Neuroscience
Sampling for SARS-CoV-2 Aerosols in Hospital Patient Rooms병원 환자 실에서 SARS-COV-2 에어로졸에 대한 샘플링Article Published on 2021-11-232022-09-10 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료법, [키워드] aerosol Aerosols airborne disease Chain Reaction Clinical characteristics collected COVID-19 COVID-19 patient Extracted floor foot gene region head hospital individual infected with SARS-CoV-2 investigated majority nine no significant differences nucleocapsid occupational participant Participants Patient patient room patient rooms Personal protective equipment polymerase chain polymerase chain reaction positive positive sample reassurance reverse transcription reverse transcription polymerase chain reaction room Safety sampling SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus selected significant difference Spread the patient the SARS-CoV-2 virus Viral viral aerosols virus [DOI] 10.3390/v13122347 PMC 바로가기 [Article Type] Article
Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine inductionResearch Article Published on 2021-11-182022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies Antiviral antiviral activity approach binding binding affinity cell entry Contact crystal structure demonstrated Effect experiment expressing glycoprotein high affinity host cell human cell Inflammation inhibiting inhibitor Interaction linear majority membrane nanobody neutralisation assay peptide peptides pro-inflammatory cytokine RBM Receptor binding domain receptor binding motif residue responsible S RBD SARS-CoV-2 SARS-CoV-2 viral selected sequence soluble ACE2 Spike protein suggested suppress the S1 subunit the SARS-CoV-2 the spike protein to define trimer viral cell viral spike viral spike protein virulence [DOI] 10.1371/journal.pone.0260283 PMC 바로가기 [Article Type] Research Article
A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 PatientsSystematic Review Published on 2021-11-112022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 5′-UTR analyzed conducted country COVID-19 deaths disease severity Effectiveness eligible Genome indicated item majority Meta-analysis MONITOR Mutation mutational profile Nucleocapsid phosphoprotein ORF1ab gene ORF3a Prevalence profile Protein random-effects model reported Reporting review SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 viral Study protocol systematic review the Spike the WHO Transmissibility USA Vaccine variants [DOI] 10.3390/life11111224 PMC 바로가기 [Article Type] Systematic Review
491. Persistence of SARS-CoV-2 Iinfection in Immunocompromised ChildrenPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 2019-nCoV 24 hour age Asymptomatic CDC center Chi-square children Clinical characteristics clinical testing Cohort Comorbidity conducted consecutive negative test consultant Control Ct value cycle threshold defined diagnose DiaSorin evaluated Factor figure Fisher had more hospital Immunocompromised immunocompromising condition immunodeficiency Immunosuppressive treatment Implications inclusion criteria infection control initial IQR Kaplan-Meier curve Latinx log-rank test lymphopenia male median median time moderate MOST negative test no difference no significant difference outcomes Panel Patient PCR pediatric persistence Pfizer platform plot polymerase chain reaction positive Positive test potential transmission Primary outcome Result retrospective cohort study risk RT-PCR Samuel SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV-2 PCR testing SARS-CoV-2 viral SAS shown specific diagnoses subsequent symptomatic temporal dynamics tested timeline unique Viral load viral loads viral persistence were used Wilcoxon test [DOI] 10.1093/ofid/ofab466.690 PMC 바로가기 [Article Type] Poster Abstracts
1088. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration airway Ambrose ambulatory patient Andrew association being binding kinetics binding site calculated CDC Complete Concentration coronavirus Course COVID-19 criteria Developed dissociation rate distribution Donald dose employee epithelial lining evaluated expressed Extended figure human IgG1 in vitro Inc Inc. indicated initial viral load intramuscularly log maintain material median Mild Model Moderate COVID-19 Molar monoclonal antibody neutralization Other pandemic patients Pharmacology phase Post-infection profile rate constant Receptor occupancy regimen regimens representing Result SARS-CoV-2 SARS-CoV-2 viral SARS-like CoV Selection Spike protein submitted Support System Therapeutics threshold Treatment Trial Van viral clearance viral growth Viral load virion Walker Wart was used were used [DOI] 10.1093/ofid/ofab466.1282 PMC 바로가기 [Article Type] Poster Abstracts
553. Outcomes in Patients Positive for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection After Treatment with Monoclonal Antibody Therapy (MAT) in the Outpatient SettingPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 95% confidence interval Admissions Analysis authorization center Clinical characteristics confounders control group coronavirus 2 coronavirus disease COVID-19 criteria determine diagnosed diagnosed with COVID-19 drug Emergency EUA evaluate food high risk Hospital admission Hospitalization Inc Lilly Logistic regression analysis Mild moderate monoclonal antibody monoclonal antibody therapy Mortality Odds ratio outcomes Outpatient Panel Patient patients positive progression receive receiving reflected Regeneron remained respiratory Result Retrospective study review SARS-CoV-2 SARS-CoV-2 viral setting severe COVID-19 single-center state statistically significant difference study cohort Symptoms Treatment university [DOI] 10.1093/ofid/ofab466.751 PMC 바로가기 [Article Type] Poster Abstracts
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication지방산 합성의 약리학적 억제는 SARS-CoV-2 복제를 차단합니다Article Published on 2021-11-012022-09-11 Journal: Nature metabolism [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] ACACA acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airways block cellular clinical clinical trials contagious coronavirus COVID-19 death Delta drug Drug administration drug candidate drug candidates Efficacy evaluate FASN fatty Fatty acid food Genes hACE2 humans identify in vitro inflammatory disease inhibit inhibiting inhibitor injection Injections Intervention K18-hACE2 K18-hACE2 transgenic mice leads lung Lung pathology Lungs metabolic genes mouse model Multi-organ damage offer orlistat pathway pharmacological promote reduced replication of SARS-CoV-2 required respiratory RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral infection screened Screening severe acute respiratory syndrome Coronavirus severe COVID-19 survival target transgenic mice Treatment treatment of COVID-19 Trial variants Viral [DOI] 10.1038/s42255-021-00479-4 PMC 바로가기 [Article Type] Article