Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemicResearch article Published on 2022-05-012022-10-05 Journal: Heart Rhythm [Category] 신약개발, [키워드] 24 hour African African American APD arrhythmia baseline cells condition conditions coronavirus disease COVID-19 COVID-19 pandemic death Drug-induced long QT syndrome early stage Effect had no HCQ Hydroxychloroquine increase in individual Induced pluripotent stem cell–derived cardiomyocyte Long QT syndrome male no difference objective p.Ser1103Tyr-SCN5A pandemic physiological polymorphism Result risk SCD SCN5A significant increase significantly significantly higher Stress Treatment variant was used [DOI] 10.1016/j.hrthm.2021.12.029 [Article Type] Research article
Trends in the Clinical Presentation of Primary Rhegmatogenous Retinal Detachments During the First Year of the COVID-19 PandemicObservational Study Published on 2022-05-012022-10-05 Journal: American journal of ophthalmology [Category] 임상, [키워드] clinical Cohort cohort patient consecutive patient coronavirus disease COVID-19 COVID-19 pandemic demographic demonstrated Detachment disease evaluate the effect Factor Final Follow-up greater logarithm median Observational cohort study outcome outcomes pandemic Patient patients treated presentation presenting proliferative vitreoretinopathy Retinal retrospective Rhegmatogenous retinal detachment significant increase significantly significantly higher treated trend visual acuity Year [DOI] 10.1016/j.ajo.2021.11.017 PMC 바로가기 [Article Type] Observational Study
Repurposing of Mycobacterium indicus pranii for the severe form of COVID-19 patients in India: A cohort studyRandomized Controlled Trial Published on 2022-05-012022-10-05 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome BST C-reactive protein Chest chest CT scan clinical study cohort study complications Computed tomography conducted consecutive patient Controlled clinical trial coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient Cytokine storm D-dimer levels decreased mortality disease double-blind Efficacy evaluate ferritin hospital India induce infected with SARS-CoV-2 Interleukins Jammu and Kashmir lung abnormality mechanical ventilation MIP Mortality Mycobacterium Mycobacterium indicus pranii normalized offer oxygen saturation placebo-controlled proinflammatory cytokines Proinflammatory response proinflammatory response and oxygen saturation. Randomized reduced reported repurposing restored SARS-CoV-2 severe COVID-19 severe COVID-19 patient significant increase significantly standard treatment Treatment two groups Ventilation [DOI] 10.1002/jmv.27547 PMC 바로가기 [Article Type] Randomized Controlled Trial
Increase in the Number of Pediatric New-Onset Diabetes and Diabetic Ketoacidosis Cases During the COVID-19 PandemicObservational Study Published on 2022-05-012022-10-05 Journal: Endocrine practice : official journal of the American College of [Category] COVID19(2023년), SARS, 임상, [키워드] 95% confidence interval black cause children Clinical data COVID-19 COVID-19 pandemic demographic diabete diabetes Diabetic disparity examined greater Hospitalization Hospitalized hyperglycemia increase induce intensive care ketoacidosis ketoacidosis. Laboratory MOST number occurred Odds ratio outcome oxygen support pandemic Patient pediatric Pediatric patient presenting proinflammatory proportion required retrospective risk SARS-CoV-2 significant increase significantly more single-center study period T2D type 2 diabete [DOI] 10.1016/j.eprac.2022.02.005 PMC 바로가기 [Article Type] Observational Study
Post-COVID-19 patients show an increased endothelial progenitor cell productionResearch article Published on 2022-05-012022-10-05 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 6-minute walk test 6MWT6-minute walk test abnormal increase ACE-2Angiotensin-Converting Enzyme 2 Admission angiotensin-converting enzyme 2 Arterial hypertension blood circulation BMIbody mass index body mass index C-reactive protein Carbon monoxide diffusing capacity cardiovascular complications Cell clinical parameter colony colony forming cell Control COVID-19 COVID-19 patient CRPC-reactive protein damaged DDDimer-D Diabetes Mellitus Dimer-D DLCOCarbon monoxide diffusing capacity DLPDyslipidemia DMDiabetes mellitus dyslipidemia ECFCEndothelial colony forming cell elevated endothelial Endothelial colony forming cell Endothelial dysfunction Endothelial progenitor cell Endothelium EPCEndothelial progenitor cell EPOerythropoietin erythropoietin evaluate FEVForced expiratory volume FIBFibrinogen fibrinogen forced expiratory volume forced vital capacity FVCForced vital capacity Gender HbHemoglobin healthy controls hematocrit hemoglobin HTAArterial hypertension HTCHematocrit hypertension Injury Isolation lactate dehydrogenase LDHlactate dehydrogenase LymLymphocytes Lymphocytes male Maximum ferritin MFMaximum ferritin no difference PaO2 PaO2Partial pressure of oxygen Partial pressure of oxygen Patient PBMC'sPeripheral blood mononuclear cells PEPulmonary Embolism Peripheral blood mononuclear cells Post-COVID-19 patients Postinfection progenitor cell Pulmonary embolism recruited Residual volume RVResidual volume SARS-CoV-2 SARS-COV-2 infection significant increase significantly subject the patient TLCTotal lung capacity Total lung capacity Vascular Vascular damage [DOI] 10.1016/j.trsl.2022.01.004 [Article Type] Research article
Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by ParvulanCOVID-19 전염병 동안의 타고난 면역 자극: Parvulan의 도전Article Published on 2022-04-292022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), SARS, 변종, [키워드] administration affected antibody antipyretics Asymptomatic average baseline challenge chronic disease Clinical course Complete consent form consultation Corynebacterium COVID COVID-19 cystitis Delta disappearance double-blind drug effective Efficacy endpoints ENhance enrolled Epidemic event Frequency full recovery Health Health status herpetic neuralgia immune response improvement Infection informed consent form injected injection Innate Innate immunity Last low-dose lymphocyte Lymphocyte count Lymphocytes mail men Mental Mild moderate network observation omicron opinion outcome Outpatient Pain pandemic parent Patient patients patients treated physical Placebo promote prostatitis Quality improvement questionnaire recurrent cystitis reduced reduction required retrospective risk Role performance Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 patient second Second opinion short term significant increase Skype Social role steroid Steroids Stimulation subcutaneously Symptom Telemedicine tested the patient Treatment variants vitality WhatsApp women [DOI] 10.1155/2022/4593598 PMC 바로가기 [Article Type] Article
Sequential IgG antibody monitoring for virus‐inactivated and adenovirus‐vectored COVID‐19 vaccine in Brazilian healthcare workersResearch Article Published on 2022-04-272022-10-04 Journal: Journal of medical virology [Category] 진단, 치료법, [키워드] acute respiratory syndrome antibody AZ vaccine booster dose convalescent individual CoronaVac coronavirus COVID‐19 COVID‐19 serological testing dose effective Effectiveness exhibited glycoprotein healthcare healthcare worker humoral IgG IgG antibody immune response immune senescence immunized Immunoglobulin Immunoglobulin G immunosorbent individual nucleocapsid protein pandemic Protein respond SARS‐CoV‐2 second dose Seroconversion seroconversion rate Side effect significant increase spike glycoprotein vaccination Vaccine were assessed were given [DOI] 10.1002/jmv.27782 PMC 바로가기 [Article Type] Research Article
Analysis of Clinical Course and Vaccination Influence on Serological Response in COVID-19 Convalescents코로나19 회복기의 임상 경과 및 백신 접종이 혈청 반응에 미치는 영향 분석Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute phase Analysis anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies antibody Blood clinical clinical and laboratory parameters concerning convalescent correlation correlations COVID-19 COVID-19 infection COVID-19 patient detection DiaSorin disease severity Gender Hospitalization Hospitalized IgG antibodies IgG test immune response Immunological response Infection Inflammation Inflammatory inflammatory parameters influence information Italy knowledge laboratory parameter Laboratory tests LIAISON lung observé parameter Patient patients response S1/S2 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serological serological test Serological tests serology severe COVID-19 severity Sex Significant significant difference significant differences significant increase significantly higher subgroup analysis symptomatic patient Symptomatic patients the disease the patient vaccination was performed [DOI] 10.1128/spectrum.02485-21 PMC 바로가기 [Article Type] Article
The COVID-19 Humoral Immunological Status Induced by CoronaVac and AstraZeneca Vaccines Significantly Benefits from a Booster Shot with the Pfizer VaccineCoronaVac 및 AstraZeneca 백신으로 유발된 COVID-19 체액 면역학적 상태는 화이자 백신으로 추가 접종을 하면 상당한 이점이 있습니다Article Published on 2022-04-272022-09-12 Journal: Journal of Virology [Category] Coronavirus, COVID19(2023년), SARS, 진단, [키워드] addition antibody Antibody Response Antiviral antiviral antibody AstraZeneca benefit booster booster shot Brazil CoronaVac country COVID-19 Critical decrease defined distribution dose Effectiveness ELISA enzyme-linked immunosorbent evaluate humoral Humoral immunity immunization immunological indicate individual induce induced infected individual natural infection participant Patient Pfizer population immunity postvaccination profile Protective protective immunity provided reduced regimen restored reveal robust SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection second dose Serum level serum levels serum samples significant increase significantly significantly higher specific antibody Spread status vaccination Vaccine vaccine dose vaccine platform [DOI] 10.1128/jvi.00177-22 PMC 바로가기 [Article Type] Article
Analyzing changes in radiotherapy treatment planning error reporting during the COVID-19 pandemicResearch article Published on 2022-04-112022-10-05 Journal: Medical Dosimetry [Category] 치료법, [키워드] affected Cancer Care change changed changes in coronavirus COVID-19 COVID-19 pandemic database determine Efficiency Error reporting event Frequency Health implementation Incident reporting multisite oncology pandemic Radiation radiation therapy Radiotherapy Remote treatment planning reported significant increase Treatment [DOI] 10.1016/j.meddos.2022.04.001 [Article Type] Research article