SOFA – Page 9 – Communicable Diseases Research

Efficacy and safety of convalescent plasma therapy in severe COVID-19 patients with acute respiratory distress syndrome

급성호흡곤란증후군 중증 코로나19 환자에서 회복기 혈장치료제의 효능 및 안전성

Clinical Trial

Published on 2021-04-012022-09-11
Journal: International immunopharmacology [Category] SARS, 임상, 치료제,

Severe acute kidney injury in critically ill COVID-19 patients

Observational Study

Published on 2021-04-012022-10-05
Journal: Journal of Nephrology [Category] SARS, 임상,

Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies

Research

Published on 2021-04-012022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, MERS,

[키워드] acute phase addition Analysis analyzed approach CD3+ CD38 CD4+ CD79B CD8+ T cells change clinical disease Coagulation coexistent consecutive patients coronavirus disease (COVID-19) correlated correlation count COVID-19 COVID-19 patient COVID-19 patients Critical CyTOF cytokine Cytometry demonstrated Differentially expressed genes disease effector memory expressed expression First wave Gene expression profiling group Hematological malignancies Hematological malignancy Hospitalized Host immune response IFIT3 IL-6 Immune cell immune response indicate Inflammation intensive care unit involved IP-10 leukemia LIPI Low T3 syndrome marker mononuclear cell multiplex NanoString NLR NLRP3 outbreak Patient patients with COVID-19 PBMC performed Peripheral blood Pneumonia presenting radiologic reduced reduction reported Result Rome SARS-CoV-2 serum Serum level serum levels severe COVID-19 severity single-cell SOFA subtype supplementary material syndrome T lymphocytes target gene the disease thyroid function tissue damage TSS university
[DOI] 10.1186/s12967-021-02805-6 PMC 바로가기 [Article Type] Research

Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study

진통 통각 지수를 사용한 심박수 변동성 모니터링이 COVID-19 중증 환자의 질병 중증도 및 사망률의 예측인자입니까? 파일럿 연구

Observational Study

Published on 2021-03-242022-09-12
Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단,

[키워드] Analysis ANIm anti-inflammatory response autonomic Autonomic nervous system autonomous conducted correlated COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients date of death death Depletion discharge domain energy Frequency heart rate HRV Hypothesis IL-6 IL-6 level IL-6 levels Illness severity intensive care unit interval limit management material mechanical ventilation MONITOR mortalities Mortality nervous system non-survivor normalized on mechanical ventilation parameter parasympathetic parasympathetic system Patient pilot study predicted Predictive Result sensitivity severity single-center SOFA SOFA score specificity Standard deviation surgical survival Time domain Variability were recorded worse prognosis
[DOI] 10.1371/journal.pone.0249128 PMC 바로가기 [Article Type] Observational Study

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

Research

Published on 2021-03-222022-10-28
Journal: Annals of Intensive Care [Category] COVID-19,

[키워드] 30-Day mortality 95% CI acute COVID-19 acute respiratory distress adjusted age ARDS AUC Biomarker calculated changes in clinician Comorbidity Concentration control group COVID-19 COVID-19 convalescent patients COVID-19 disease severity COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 symptoms critically ill patients cut-off determine dialysis disease disease severity elevated ELISA Gender Germany healthy control healthy volunteer High-flow nasal oxygen IMPROVE Increases information Inpatient intensive care unit male management mechanical ventilation Mortality need for oxygen Non-COVID-19 Observational cohort study Odds ratio Organ failure organ support Patient Pneumonia predict prediction primary endpoint qSOFA RAGE receptor Respiratory failure Result risk secondary endpoint serum severe disease severity shown SOFA Soluble RAGE subsequent supplementary material Support syndrome therapy Variation was measured were measured with COVID-19
[DOI] 10.1186/s13613-021-00836-2 PMC 바로가기 [Article Type] Research

An open label trial of anakinra to prevent respiratory failure in COVID-19

COVID-19에서 호흡 부전을 예방하기 위한 아나킨라의 공개 라벨 시험

Clinical Trial

Published on 2021-03-082022-08-13
Journal: eLife [Category] SARS, 바이오마커, 임상,

[키워드] 30-Day mortality 95% CI Administering Anakinra antagonists approach Arthritis assigned balance Biomarker blood protein blood sample Care cause circulating class clinical Combination COVID-19 COVID-19 patients death rate death rates decrease defined develop drug effective examined form framework funding hazard ratio help highest Horizon Human identify immune function immune response immune system IMPROVE incidence individual infected individual Infection Inflammation Inflammatory Inflammatory mediators injection interleukin-10 investigated less marker medication medications non-invasive ventilation once daily open label outcome Pain Patient Pneumonia Prevent Primary outcome progressed progression Protein receptor reduce reduced respiratory Respiratory failure respiratory ratio respond restored rheumatoid arthritis risk risk of death Safe SARS-CoV-2 SARS-CoV-2 virus secondary outcome Sepsis severe respiratory failure Side effects significantly SOFA SOFA score soluble urokinase plasminogen activator receptor SRF suggested suPAR Swedish Orphan Biovitrum swelling the SARS-CoV-2 virus treat treating COVID-19 patient Treatment Trial ventilator while WHO-CPS
[DOI] 10.7554/eLife.66125 PMC 바로가기 [Article Type] Clinical Trial

Effect of early treatment with polyvalent immunoglobulin on acute respiratory distress syndrome associated with SARS-CoV-2 infections (ICAR trial): study protocol for a randomized controlled trial

SARS-CoV-2 감염과 관련된 급성 호흡 곤란 증후군에 대한 다가 면역글로불린의 조기 치료 효과(ICAR 시험): 무작위 대조 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-02-282022-09-01
Journal: Trials [Category] MERS, 임상, 진단,

[키워드] 1:1 90% power activities activity acute respiratory distress acute respiratory distress syndrome administration adverse event Alpha ARDS assessment chloride coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 daily living defined died double-blind early treatment Effect effect size Efficacy and safety EudraCT evaluate evaluate the effect failure France functional GRADE grade 3 Hospital stay Hospitalized ICU Immunoglobulin immunomodulatory increase in intensive care intensive care unit Intravenous immunoglobulin IVIG Lung injury mechanical ventilation morbidity mortality rate multicenter Occurrence Organ failure outcome parallel group participant Patient pharmacological treatment placebo group Polyvalent immunoglobulin Primary outcome Randomized Randomized controlled trial receive reduction in respiratory distress SARS-CoV-2 SARS-COV-2 infection Secondary objective Secondary objectives sequential design Sodium chloride SOFA Study protocol subject survival survival rate syndrome the placebo group treatment group Trial Trial registration ventilator-free day Ventilator-free days Volume were infected with COVID-19
[DOI] 10.1186/s13063-021-05118-7 PMC 바로가기 [Article Type] Study Protocol

Outcome Prediction in Patients with Severe COVID-19 Requiring Extracorporeal Membrane Oxygenation—A Retrospective International Multicenter Study

Article

Published on 2021-02-272022-10-31
Journal: Membranes [Category] COVID-19,

[키워드] Accuracy acute respiratory distress acute respiratory distress syndrome APACHE II ARDS assessment Belgium benefit calculated chronic Cohort COVID-19 COVID-19 patient criteria cut-off value defined enrolled evaluate Extracorporeal extracorporeal membrane oxygenation failure Germany International invasive investigator-initiated Italy large cohort Mortality multicenter multicenter study non-COVID-19 ARDS patient Patient patients patients treated Physiology predict prediction Prognosis prognostic ranged Registered reported respiratory retrospective SARS-CoV-2 score severe COVID-19 SOFA study cohort survival Switzerland syndrome The United States therapy treated Treatment V-V ECMO
[DOI] 10.3390/membranes11030170 PMC 바로가기 [Article Type] Article

Macrophage Migration Inhibitory Factor (MIF) Plasma Concentration in Critically Ill COVID-19 Patients: A Prospective Observational Study

Article

Published on 2021-02-172022-10-31
Journal: Diagnostics [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) Admission approach ARDS arterial association Biomarker Clinical course Clinical outcome Comorbidity Concentration coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient described diagnostic evaluate Factor hallmark high risk Horowitz Quotient hypertension ICU ICU treatment identify Ill IMPROVE Increased inhibitory intensive care Macrophage Migration Inhibitory Factor (MIF) management mechanically ventilated MIF Migration Organ failure organ function outcome Patient Perspective pharmacological treatment Predictive predominant Prospective prospective observational study severe COVID-19 disease Severe COVID-19 Infection significantly significantly lower SOFA SOFA score survival syndrome Treatment strategies were measured
[DOI] 10.3390/diagnostics11020332 PMC 바로가기 [Article Type] Article

Clinical significance of cellular immunity function and inflammatory factors assays in alveolar lavage fluid for severe COVID‐19 pneumonia

Research Article

Published on 2021-02-092022-10-04
Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커,

[키워드] affecting alveolar alveolar lavage fluid assessment assigned C‐reactive protein CD3 CD4 CD8 Cell cell count cells cellular immunity change chronic clinical impact Clinical significance collected correlated COVID‐19 COVID‐19 death group disease severity failure flow cytometry hypersensitive ICU admission IL‐6 immunoturbidimetry independent risk factor Inflammatory factor inflammatory factors intensive care Lymphocyte subset Patient PCT Peripheral blood Physiology Pneumonia procalcitonin Prognosis serum severe patients severity significantly higher SOFA SOFA score statistically survival group
[DOI] 10.1002/jmv.26827 PMC 바로가기 [Article Type] Research Article