Emergence and Spread of a B.1.1.28-Derived P.6 Lineage with Q675H and Q677H Spike Mutations in Uruguay우루과이에서 Q675H 및 Q677H 스파이크 돌연변이를 갖는 B.1.1.28 유래 P.6 계통의 출현 및 확산Article Published on 2021-09-102022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] analyzed B.1.1.28 cleavage site dissemination emergence epidemic wave Evidence evidence of followed by genetic diversity Lineage lineages Local Mutation nine P.1 P.2 pandemic phylogenetics phylogeography predominant prevalent Q675H Q677H replaced REPLACED BY S1/S2 boundary SARS-CoV-2 SARS-CoV-2 pandemic Spain spike Spread spread to the SARS-CoV-2 Transmission Uruguay USA variant Viral viral variant VoC VOCs [DOI] 10.3390/v13091801 PMC 바로가기 [Article Type] Article
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5Article Published on 2021-09-072022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Activation Calu-3 cell caused CCL5 change circulating clade Contact Ex vivo experiment functional Human IFN IFNB1 IFNL1 immune gene in vitro innate immune isolate Lineage lung cell MERS-CoV Middle East nosocomial outbreak onward transmission pandemic parental phenotypic Pneumonia receptor reduced remained Replication replicative fitness respiratory syndrome coronavirus reveal Saudi Arabia sequence Signaling significantly increased South Korea spread to Strains Surveillance viral epidemiology viral evolution Viral immune evasion virus viruses [DOI] 10.1038/s41467-021-25519-1 PMC 바로가기 [Article Type] Article
Multiepitope Proteins for the Differential Detection of IgG Antibodies against RBD of the Spike Protein and Non-RBD Regions of SARS-CoV-2Article Published on 2021-09-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence Analysis analyzed antibodies approach Asymptomatic carrier benefit chimeric contributed coronavirus COVID-19 COVID-19 pandemic de novo De novo design detection Diagnostic method diagnostic tests Diseases ELISA epitope generate identify IgG immunological linear B cell epitopes non-specific offer pathogen platform populations produced Protein RBD reactivity Region SARS-CoV-2 sequence serodiagnostic serological test similarity spread to target the RBD the receptor-binding domain the Spike the spike protein Transmission virus while Wuhan, China [DOI] 10.3390/vaccines9090986 PMC 바로가기 [Article Type] Article
The Role of Micronutrients to Support Immunity for COVID-19 PreventionReview Published on 2021-09-022022-10-29 Journal: Revista Brasileira De Farmacognosia [Category] COVID-19, [키워드] boost caused Coronavirus infection country COVID-19 death Effect Evidence global pandemic healthy immune response immune system ingestion ingredient macromolecule mechanism Micronutrient mineral Minerals Novel coronavirus nutrition prevention PROTECT reduction in role SARS-CoV-2 serious infections spread to Supplements the disease Vitamin vitamins World Health Organization [DOI] 10.1007/s43450-021-00179-w PMC 바로가기 [Article Type] Review
Knowledge, awareness and practices of Pakistani professionals amid-COVID-19 outbreakClinical Trial Published on 2021-09-022022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] addressed caused China contagious coronavirus country COVID-19 curative disease effective End evaluate Health care healthcare include indicated individual Infection information Italy Keeping measure media medication Microbiology Molecular biology outbreak pandemic performed persistence preventive measures professional professionals question questionnaire recorded response responses against Self-isolation Spain Spread spread to SPSS software susceptible the disease the SARS-CoV-2 Vaccine virus WHO World Health Organization [DOI] 10.1038/s41598-021-96705-w PMC 바로가기 [Article Type] Clinical Trial
Could the new coronavirus have infected humans prior November 2019?Research Article Published on 2021-08-192022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] calculated caused China Cluster confidence interval country Epidemics expression growth Human individual Italian Italy journal New coronavirus outbreak pandemic reported representing spread to stroke the epidemic the SARS-CoV-2 virus unlikely virus [DOI] 10.1371/journal.pone.0248255 PMC 바로가기 [Article Type] Research Article
Plant-Produced Glycosylated and In Vivo Deglycosylated Receptor Binding Domain Proteins of SARS-CoV-2 Induce Potent Neutralizing Responses in MiceArticle Published on 2021-08-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 antibody antigens Antiviral binding caused country COVID-19 COVID-19 pandemic elicited enzyme global public health glycosylated greater high risk immunized in vivo knowledge mice monoclonal antibody Neutralizing activity Nicotiana benthamiana plant potent prevention of COVID-19 produced Protein purification purified RBD RBD antigen RBD protein RBD proteins RBD-specific antibody reactivity receptor Receptor binding domain receptor binding domain (RBD) vaccine response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 vaccines Spike protein spread to Support the SARS-CoV-2 therapeutic drug transient expression system vaccine candidate vaccine candidates virus-neutralizing [DOI] 10.3390/v13081595 PMC 바로가기 [Article Type] Article
Transmission dynamics of SARS-CoV-2 in a mid-size city of ChinaResearch Article Published on 2021-08-102022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition affected Asymptomatic carrier asymptomatic patient asymptomatic patients basic reproductive number case sery characteristic Characteristics China Chinese Clinical characteristics Contact coronavirus cough country COVID-19 described effective epidemiological evaluated example female global pandemic had no help individual Intervention lowest median age outbreak pandemic Patient Pneumonia Prevention and control measures Public health intervention R0 Rt reached Reproduction number Result SARS-CoV-2 SARS-CoV-2 transmission spread to supplementary material Symptom Symptoms the epidemic the patient Transmission Transmission dynamics Wuhan [DOI] 10.1186/s12879-021-06522-9 PMC 바로가기 [Article Type] Research Article
Neurological manifestations in mild and moderate cases of COVID-19Research Published on 2021-08-042022-10-31 Journal: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery [Category] COVID-19, [키워드] acute phase added China CNS collected collected data Concentration coronavirus disease country COVID-19 COVID-19 patient Dizziness Encephalitis Encephalopathy fatigue headache Health Home-isolated patients Infection information Invasion less manifestation Mild mild cases moderate Moderate COVID-19 myalgia neurological neurological manifestation neurological manifestations pandemic Patient patients questionnaire reached recorded reported Result Seizures spread to stroke Support Symptom syndrome the disease virus while Wuhan [DOI] 10.1186/s41983-021-00363-8 PMC 바로가기 [Article Type] Research
Understanding COVID-19 in Africa아프리카의 COVID-19 이해Article Published on 2021-08-012022-09-11 Journal: Nature reviews. Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Asymptomatic Comorbidities containment measures coronavirus disease Coronavirus disease 2019 country COVID-19 environmental factors explain Factor heterogeneity heterogeneous host genetics immune factors majority pandemic Prevalence prevalence of COVID-19 SARS-CoV-2 variant SARS-CoV-2 variants serological studies Spread spread to status thought understanding Vaccine [DOI] 10.1038/s41577-021-00579-y PMC 바로가기 [Article Type] Article