Estimating the Effects of Public Health Measures by SEIR(MH) Model of COVID-19 Epidemic in Local Geographic AreasPublic Health Published on 2022-01-042022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] age Area Belgium Comparative COVID-19 COVID-19 pandemic dynamic Effect effective Epidemic Europe Geographic hospital Hospital capacity linear lockdown lombardy management mathematical model measure medical system Model modeling outcome parameter patients Public Public health policies public health system public health systems Region SEIR structures Support Switzerland [DOI] 10.3389/fpubh.2021.728525 PMC 바로가기 [Article Type] Public Health
Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface diseaseObservational Study Published on 2022-01-012022-10-05 Journal: The Ocular Surface [Category] SARS, 임상, [키워드] alteration association asymptomatic patients Cell confocal microscopy control group Corneal Corneal neuropathy COVID-19 COVID-19 infection dendritic cells Diabetic disease Dry Dry eye Dry eye disease examined eye fiber healthy subject Image in vivo In vivo confocal microscopy. index Infection Morphological ocular Ocular surface overcome pathology Patient patients positive questionnaire recruited reported Retrospective study small fiber structures subject surface Symptoms tissue tissue damage uninfected Volunteer were used [DOI] 10.1016/j.jtos.2021.10.010 PMC 바로가기 [Article Type] Observational Study
Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells일시적인 미니 풀 유래 및 단일 클론 CHO 세포 전반에 걸친 SARS-CoV-2 중화 항체의 품질 동등성 평가Comparative Study Published on 2022-01-012022-09-12 Journal: mAbs [Category] SARS, 진단, [키워드] accelerate acute respiratory syndrome adopted Cell cell line Chemistry Chinese hamster CHO cell clinical trial comparability comparable conducted Control coronavirus Degradation immunological functions indicated measure mini-pool monoclonal antibody Neutralizing neutralizing antibody patients Phase 1 profiles public health crisis Quality Research SARS-CoV-2 SARS-CoV-2-neutralizing antibody Spike protein stress condition structures Support the disease the SARS-CoV-2 therapeutic transient. triggered Variation [DOI] 10.1080/19420862.2021.2005507 PMC 바로가기 [Article Type] Comparative Study
Placental deficiency during maternal SARS-CoV-2 infection산모의 SARS-CoV-2 감염 중 태반 결핍Multicenter Study Published on 2022-01-012022-09-12 Journal: Placenta [Category] MERS, SARS, 진단, [키워드] abnormality age anti-SARS-CoV-2 anti-SARS-CoV-2 IgM antibody change Clinical severity collected Concentration correlated COVID-19 cross deficiency disease evaluate feature fetal Gross histopathological indicated Infection Maternal moderate mother Nasopharyngeal swab Neonatal Neonate Neonates outcome outcomes pathology Placenta placental Placental infection Placental pathological findings positive Pregnancy pregnant women prospective cohort study Prospective Study Protein reported risk SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection sera severe disease severity spike staining structures Swab the disease transmission of SARS-CoV-2 umbilical [DOI] 10.1016/j.placenta.2021.10.012 PMC 바로가기 [Article Type] Multicenter Study
COVID-19 Daily Realities for Families: A South African SampleArticle Published on 2021-12-252022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] affected African approach assist contrary COVID-19 COVID-19 pandemic Daily events exploratory family family experiences finding Health Health status Impact include Intervention lack management outcome pandemic positive psychological impacts REALITY Research Sample South South Africa structures [DOI] 10.3390/ijerph19010221 PMC 바로가기 [Article Type] Article
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data sciencePykvfinder : 데이터 과학의 생체 분자 공동 탐지 및 특성을위한 효율적이고 통합 가능한 파이썬 패키지Software Published on 2021-12-202022-09-10 Journal: BMC Bioinformatics [Category] 치료기술, [키워드] Analysis automated Automated pipelines biological processe biological processes block blocks Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction machine learning mathematical modulate molecular dynamics NumPy occur proof Protein protocols Python Result SARS-CoV-2 SciPy structural biology Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data scienceSoftware Published on 2021-12-202022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Analysis automated Automated pipelines biological processe block Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction mathematical modulate molecular dynamics NumPy occur Protein protocols Python Result SARS-CoV-2 SciPy Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
pyKVFinder: an efficient and integrable Python package for biomolecular cavity detection and characterization in data scienceSoftware Published on 2021-12-202022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, [키워드] Analysis automated Automated pipelines biological processe block Cavity characterization Cavity detection Computational methods Data analysis Data science Data structure detect drug design ecosystem facilitate homologous hydropathy Interaction mathematical modulate molecular dynamics NumPy occur Protein protocols Python Result SARS-CoV-2 SciPy Structure structures supplementary material Volume [DOI] 10.1186/s12859-021-04519-4 PMC 바로가기 [Article Type] Software
LinearTurboFold: Linear-time global prediction of conserved structures for RNA homologs with applications to SARS-CoV-2408 Published on 2021-12-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Algorithm Antisense oligonucleotides conserved conserved structures coronavirus Coronaviruses COVID-19 Critical diagnostic diagnostics disease drugs Effectiveness effort experimental work faster full-length full-length genome functions Genome genomes guide RNAs help homolog homologous folding homologs identify in silico Interaction knowledge Local magnitude Pandemics predict Primers reduce Region RNA RNA secondary structure RNA structure RNA virus RNA viruses RT-PCR SARS-CoV-2 sequence Significance siRNAs structural alignment Structural analysis Structure structures target therapeutic UTRs Vaccine variant variants viral genomes whole genome [DOI] 10.1073/pnas.2116269118 PMC 바로가기 [Article Type] 408
Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific glial proteinsSARS-COV-2 스파이크 에피토프 서열의 분자 도킹으로 인간 Zo-1, TLR8 및 뇌 특이적 신경교 단백질과의 이종이량체 펩티드-단백질 복합체 형성 확인Article Published on 2021-12-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 유전자 메커니즘, [키워드] allele asphyxia binding Blood brain barrier blurred vision Brain Brain infection cause clinical observation clinical observations complex death deviation docking epitope epitope peptide Epitopes experiment Glia glial cell headache heterodimeric HLA-DRB1 Human brain human population Hypothesis identify immunogenic induce infect Infection Inflammation Interaction Loss of Smell mechanism modify molecular molecule NDRG2 neurological abnormalities neurological abnormality observation observations peptide peptides performed Protein Proteins question receptor respiratory tract illness RMSD root S100B SARS-CoV-2 SARS-COV-2 infection selected sequence specific protein spike spike epitopes Spike protein structures Symptoms tested the Spike TLR TLR8 Toll-like receptor VCAM1 virus working hypothesis zonula zonula occludens [DOI] 10.1016/j.mehy.2021.110706 PMC 바로가기 [Article Type] Article