Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
5 개의 면역 저하 환자 및 전향 적 개방형 임상 시험에서 건강한 대조군에서 SARS-COV-2에 대한 mRNA BNT162B2 백신의 안전성 및 효능
Research paper
[키워드] Adverse
adverse events
Adverse reaction
Allogeneic
allogeneic hematopoietic stem cell transplantation
Antibody titre
antibody titres
BNT162b2
BNT162b2 mRNA
BNT162b2 mRNA vaccination
CAR T, Chimeric antigen receptor T
CAR-T
Cell
Cell therapy
certain immunocompromised patient groups
chronic lymphocytic leukemia
clinical trial
clinical trials
CLL
CLL, Chronic lymphocytic leukemia
Control
controls
Council
COVID-19, Coronavirus disease 2019
disorder
Efficacy
event
excluded
finding
FIVE
five group
foundation
funding
generally mild
group
healthy control
healthy controls
Hematopoietic stem cell
highlight
HIV
HIV, Human immunodeficiency virus
HSCT, Allogeneic hematopoietic stem cell transplantation
Human immunodeficiency virus
human stem-cell transplantation
Ibrutinib
Immunity
Immunocompromised
Immunocompromised patient
immunocompromised patient group
Immunocompromised patients
immunodeficiency disorder
immunodeficiency disorders
IMPROVE
Infection
ITT, Intention to treat
Knut
leukemia
Lymphocytic leukemia
mPP, Modified per protocol
mRNA BNT162b2 vaccine
mRNA vaccination
mycophenolate
mycophenolate mofetil
occurred
of BNT162b2
Open-label
organ transplantation
organization
organizations
Patient
patient group
patient groups
PID, Primary immunodeficiency disorders
PP, Per protocol
primary endpoint
Primary Immunodeficiency
Prospective clinical trial
Rate
Region
Safe
Safety
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
second dose
secondary endpoint
Secondary endpoints
selected
serious adverse reaction
Seroconversion
seroconversion rate
seroconverted
solid organ
solid organ transplantation
SOT
SOT, Solid organ transplantation
stem cell
subgroups
subject
Swedish
T cell
therapy
Treatment
vaccination against COVID-19
vaccine dose
virus infection
[DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper
[DOI] 10.1016/j.ebiom.2021.103705 PMC 바로가기 [Article Type] Research paper