The Cell Tropism of Porcine Respiratory Coronavirus for Airway Epithelial Cells Is Determined by the Expression of Porcine Aminopeptidase NArticle Published on 2020-10-232022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] abundantly expressed air–liquid interface air–liquid interface culture airway airway epithelial cell aminopeptidase Analysis apical membrane APN applied bronchial cell bronchial epithelial cell Cell cell tropism cells cellular receptor complex Coronaviruses Culture determined by disease domain epithelial cell expected Express expression immortalized cell lines in vitro infect Infection mild respiratory non-mucus-producing occurred porcine aminopeptidase N porcine respiratory coronavirus reported respiratory Respiratory Coronavirus respiratory tract susceptibility susceptible target the cell tracheal tropism virus virus entry [DOI] 10.3390/v12111211 PMC 바로가기 [Article Type] Article
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic뮤신-1 감소 화합물에 대한 고함량 검사를 통해 포스타마티닙이 COVID-19 대유행 기간 동안 급성 폐 손상에 대한 신속한 용도 변경을 위한 후보로 확인됨Article Published on 2020-06-302022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] acute lung injury apical surface approved ARDS arising biochemical marker breath candidate Cell cell surface clinical development clinical outcomes clinical trial clinical trials Compound content COVID-19 pandemic distress drug drug candidate Drug repurposing Efficacy elevated epithelial cells expressed fostamatinib identify Immune thrombocytopenia inhibitor Lung disease lung epithelial cell Lung epithelial cells Lung injury membrane-bound mouse model MUC1 mucin mucosal pandemic pandemic spread Patient patients with COVID-19 predict promoted Protein provide R788 Rapid rationale reduce reduced repurposing required respiratory distress Respiratory distress syndrome reveal SARS-CoV-2 SARS-COV-2 infection Screen spleen Spread Stage standing up SYK syndrome the cell thrombocytopenia Treatment tyrosine [DOI] 10.1101/2020.06.30.180380 PMC 바로가기 [Article Type] Article
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes모노티올 글루타레독신 Grx3의 단백질체 프로파일링은 철 의존적 과정의 조절에서 그것의 전체적인 역할을 보여줍니다Research Article Published on 2020-06-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affinity purification amplify applied approach associations biological processes Candida albican Candida albicans Cell cellular processes cofactor commensal component conserved Critical cytosolic determine DNA essential nutrient expression function functions fungal Gene Expression genotoxic glutaredoxin growth Grxs Heat shock histidine homeostasis Host human host humans in vivo interact iron iron homeostasis leucine maintain mass spectrometry metabolism mutant organism Organisms oxidative oxygen pathogen Pathogens performed Protein protein translation proteomic regulate Regulation regulatory circuit repair repression required respond reveal sulfur Support survival Taking target gene Target genes the cell Tryptophan utilization virulence [DOI] 10.1371/journal.pgen.1008881 PMC 바로가기 [Article Type] Research Article
The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome studySARS-CoV-2 수용체 ACE2 단일 세포 전사체 연구에 의한 모체-태아 경계면 및 태아 기관의 발현Research Article Published on 2020-04-162022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] abortion ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 caused Cell cell type cell types changed Characteristics Clinical practice collected coronavirus cytotrophoblast decidua diagnosed enzyme evaluate exhibited expressed expression fetal global public health human infection human infections investigated kidney liver lung mice Neonatal organ organs perivascular perivascular cells Placenta Pneumonia receptor respiratory SARS-CoV-2 SARS-CoV-2 receptor scRNA-seq severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell Single-cell RNA sequencing Spread stromal cell stromal cells the cell the SARS-CoV-2 Transcriptome Transmission vertical transmission virus WHO [DOI] 10.1371/journal.pone.0230295 PMC 바로가기 [Article Type] Research Article
Expression of a novel class of bacterial Ig-like proteins is required for IncHI plasmid conjugationIncHI 플라스미드 접합을 위해서는 새로운 종류의 세균성 Ig 유사 단백질의 발현이 필요합니다Research Article Published on 2019-09-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (colistin Antibiotic resistance Antibiotics antimicrobial resistance Bacterial bacterial cell bacterial cells Bacterial infections caused Cell cell motility cells cellular cellular structure coding colistin Contact contribute Critical determinants dissemination DNA domain enterobacteria Enterobacteriaceae Europe Express expression facilitate flagella group Infection instances interact Interaction involved liquid medium mating pair medium multidrug-resistant occur ORF Plasmid plasmids Population Protein reduce reported required restrict retained Salmonella secretion significantly Spread target the cell transfer Transmission Treatment widespread [DOI] 10.1371/journal.pgen.1008399 PMC 바로가기 [Article Type] Research Article
SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilisSweC와 SweD는 Bacillus subtilis에서 FtsEX-CwlO 세포벽 가수분해효소 복합체의 필수 보조인자입니다.Research Article Published on 2019-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABC Amino acid amino acid substitution amino acid substitutions ATPase Author autolytic enzymes Bacillus subtilis Bacteria bacterial cell bacterial species Cell cell division cell wall characterized cleavage complex composed conserved Control control cell cytokinesis division divisome domain enzyme Factor firmicutes function gram gram-positive bacterium growth homologs hydrolase Hydrolases involved mechanism membrane osmotic lysis peptide peptides peptidoglycan performed Prevent PROTECT Protective Protein regulate regulated Regulatory remodeling required residue residues sacculus subset Support synthesis the cell [DOI] 10.1371/journal.pgen.1008296 PMC 바로가기 [Article Type] Research Article
Essential gene deletions producing gigantic bacteria거대 박테리아를 생성하는 필수 유전자 결실Research Article Published on 2019-06-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accelerated Acinetobacter Analysis antibiotic Antibiotics Bacteria Bacterial Bacterial infections blocked Cell cell wall cell wall synthesis cells cleave consequence conserved creating dead dead cell dead cells deleted Deletion eliminating enzyme Essential feature function functions Genetic Giant giant cell giant cells help hydrolysis identify inactivated independent life lysed lytic transglycosylase mutant mutants Mutation natural transformation osmotic overcome overlapping pathogenic pathway peptide peptidoglycan polymerization precursor predicted produced producing required respond responsible resulting sacculus targets the cell the dead Tn-seq transposon Treatment [DOI] 10.1371/journal.pgen.1008195 PMC 바로가기 [Article Type] Research Article
Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function이 기능을 수행할 수 없는 모 단백질로부터 Saccharomyces eubayanus의 새로운 키메라 말토트리오스 수송체의 진화Research Article Published on 2019-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptive breakpoint bypassing Cell changes in Chimera chimeric classic Deleterious determine domain duplicate gene ectopic recombination epistatic interaction epistatic interactions Evolution example experiment function functional functions gene encoding Gene Expression gene sequence generate genes encoding Genetic hybrid Interaction lack less limit locus MALT malt extract maltose maltotriose mapped molecular multiple mutation multiple mutations occurred overexpressing paralog paralogs performed Point mutation proceed Protein Proteins provide Recombination Research Saccharomyces cerevisiae sequence strain Strains Substitution substitutions sugar Support the cell thought Transport transporter while wild strain wild strains yeast [DOI] 10.1371/journal.pgen.1007786 PMC 바로가기 [Article Type] Research Article
Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathwayCek1 경로의 활성화에 의해 칸디다 알비칸스 β(1,3)-글루칸의 노출이 촉진됩니다Research Article Published on 2019-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition AIDS antigenic approach biogenesis bloodstream Cancer patients Candida Candida albican Candida albicans cascades cause Cdc42 Cell cell wall cell wall synthesis decrease detect disrupt Disruption downstream drug exhibit exposure Fungal infection fungal infections fungal pathogens glucan glycosylated GTPase homozygous Hyperactivation immune immune cells immune function immune system increase independent innate immune cell Innate immune cells Intracellular kinase kinases lab lead leads mannan MAPK masking mitogen Mortality mutant Mutation Pathogens pathway Patient Phosphatidylserine polysaccharide promoted protein kinase receptor receptors regulate remodeling responsible Signaling signaling cascade significantly increased synthesis the cell up-regulated upregulated upregulation upstream virulence virulence factor weakened were used wild-type wild-type cell wild-type cells [DOI] 10.1371/journal.pgen.1007892 PMC 바로가기 [Article Type] Research Article
A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery박테리아 세포 신장 기계에 의한 펩티도글리칸 중합의 활성화에서 PBP2의 중심 역할Research Article Published on 2018-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin activate activated Activation activation pathway activities activity Analysis antibiotic Author Bacteria bacterial cell biogenesis Cell Cell elongation cell wall cell wall synthesis changes in complex complexes component conserved Control control cell crosslinking cytokinesis cytoskeletal filament cytoskeletal filaments determine disrupt enzymatic activity enzyme Enzymes Escherichia coli Evidence exhibited Genetic genetic evidence glycan glycan polymerase glycan polymerases hyperactivate identify in vitro in vivo inactivated morphogenic MreB Mutation osmotic lysis pathway PBP PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins polymerase Prevent promote PROTECT provide remained required Rod system RodA stimulate the cell uncrosslinked variant [DOI] 10.1371/journal.pgen.1007726 PMC 바로가기 [Article Type] Research Article