Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro다양한 용도 변경 약물과 결합된 몰누피라비르는 시험관 내 인간 비강 상피에서 SARS-CoV-2 감염을 추가로 억제합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Air-liquid interface antiviral activity Antiviral treatment antiviral treatments antivirals caused cellular Clinical efficacy clinical testing clinically Combination combinations complex Compound Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug drug combination drug combinations Drug repurposing effective effective antiviral treatment effort Emergency use evaluated highlighting identify Immunity in vitro in vitro model inhibit inhibiting molnupiravir nasal epithelium Potential treatment Repurposed drug SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected severe acute respiratory syndrome Coronavirus short duration tested the vaccine These data Treatment Vaccine variant worldwide pandemic [DOI] 10.1016/j.biopha.2022.113058 PMC 바로가기 [Article Type] Article
Salivary antibodies are detected with a commercial anti-SARS-CoV-2 assay only after two doses of vaccine using serum thresholds타액 항체는 혈청 역치를 사용하여 백신을 2회 접종한 후에만 상용 항-SARS-CoV-2 분석으로 검출됩니다.Article Published on 2022-06-012022-09-11 Journal: Clinical biochemistry [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Anti-spike antibody antibody assay BNT162b2 BNT162b2 vaccine Cohort collected convalescent COVID-19 patient COVID-19 COVID-19 serology declined detect dose feasibility first dose Matched nucleic acid of BNT162b2 Pfizer-BioNTech Quantitative receiving Roche Diagnostics Saliva saliva samples salivary SARS-CoV-2 second dose serology serum Serum level serum levels single dose specimen Surveillance tested These data threshold thresholds Total U/mL vaccination Vaccine vaccine dose Volunteer [DOI] 10.1016/j.clinbiochem.2022.02.002 PMC 바로가기 [Article Type] Article
An overview of COVID-19 in solid organ transplantationReview article Published on 2022-06-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] acute COVID-19 anti-inflammatory treatment Antiviral approach article candidate Case series changes in Contact content Course COVID-19 COVID-19 infection COVID-19 pandemic defined Donor Donor selection Donor-derived infections evaluated feasible General population Google Scholar hygiene Impact increasingly Infection Intervention Lung disease lung transplant Mortality notable objective occur other organ outcomes PCR-positive performed physical distancing prevention prevention of COVID-19 recipient recipients SARS-CoV-2 SARS-COV-2 infection searched solid organ transplantation solid organ transplants SOT Source These data Transplant candidates transplantation Treatment vaccination Volume Web of Science [DOI] 10.1016/j.cmi.2022.02.005 [Article Type] Review article
Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season2021-22 북반구 인플루엔자 시즌을 계속 지배하는 H3N2 변이체의 항원 및 바이러스 특성Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] 변종, [키워드] Alter antibodies antibody antigenic antigenic mismatch binding COVID-19 pandemic CP: Microbiology elicited glycosylation site H3N2 H3N2 strain hemagglutinin Hemisphere human airway cells human cell human cells Influenza influenza vaccine Influenza virus influenza viruses maintain Microbiology neutralize population immunity replicate sialic acid Substitution These data these viruses Vaccine vaccine strain variant Virological virus [DOI] 10.1016/j.celrep.2022.110897 PMC 바로가기 [Article Type] Article
Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise에어로졸 입자 방출은 기하 급수적으로 기하 급수적으로 증가하여 최대 운동 동안 초강력을 초래합니다.Article Published on 2022-05-312022-08-31 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol aerosol particle concentration aerosol particle emission Affect airway Concentration coronavirus During Exercise eight event exercise exhale Exhaustion expired air explain Factor graded exercise test greater hydration status increase Infection prevention intensity investigation measure men moderate Particle Particles pathogen Pathogens physical activity pulmonary ventilation respiratory resulting SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex difference significantly significantly more subject subjects These data transmitted Ventilation Volume women [DOI] 10.1073/pnas.2202521119 PMC 바로가기 [Article Type] Article
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccineSARS-CoV-2 mRNA 백신 3차 접종 후 오미크론 반응성 B 세포 기억의 효율적인 회수Article Published on 2022-05-262022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] added Alpha antibody Antibody titer Antibody titers Antigen B cell memory Beta booster Cell circulating antibodies circulating antibody correlated COVID-19 Delta dose efficient examined fold immune immune memory Immunity IMPROVE increase in limit memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine neutralizing antibody titers omicron Omicron variants quantity RBD-specific memory B cells recall remained response SARS-CoV-2 spike These data vaccination Vaccine variants variants of concern wild-type [DOI] 10.1016/j.cell.2022.04.009 PMC 바로가기 [Article Type] Article
Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease Research Published on 2022-05-262022-10-05 Journal: NPJ Vaccines [Category] 변종, 유전자 메커니즘, [키워드] antibody Antigen antigenicity BALB/c mice Combination comparable convalescent plasma COVID-19 cases COVID-19 pandemic defined disease effective vaccine elevated elicited Emergency use Endpoint facilitate highlight immunization immunized immunogenic infected patients Infection Live virus Lung infection MERS-CoV neutralization titer neutralizing antibody responses Particle pathogenic coronavirus physiochemical property platform PLP PROTECT Protein provide RBD RBD-specific IgG robust SARS-CoV-2 SARS-CoV-2 variant serum the receptor-binding domain the United State These data Vaccine Vaccines [DOI] 10.1038/s41541-022-00481-1 [Article Type] Research
Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in miceClofoctol은 SARS-CoV-2 복제를 억제하고 쥐의 폐 병리를 감소시킵니다Article Published on 2022-05-192022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] antiviral activity Bacterial cells Clofoctol Compound compounds COVID-19 patients drug Drug repurposing exhibited exhibiting Gene Expression geographical areas human ACE2 receptor human lung IC50 identify Inflammatory inhibit investigated library Lung pathology mice peak concentration pharmacokinetic Pulmonary pathology reduce reduced Registered Regulatory Respiratory tract infections safety profile SARS-CoV-2 SARS-CoV-2 replication screened Support tested therapeutic Therapeutic treatment These data transgenic mice Treatment treatment of COVID-19 patients Viral load [DOI] 10.1371/journal.ppat.1010498 PMC 바로가기 [Article Type] Article
mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functionsmRNA-1273 및 BNT162b2 COVID-19 백신은 Fc 매개 효과기 기능에 차이가 있는 항체를 유도합니다Article Published on 2022-05-182022-09-11 Journal: Science Translational Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody approved binding BNT162b2 cell activation Cohort Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Efficacy elicit epitope evade Fc-mediated effector function function functional functional capacity Hospital staff humoral immune response humoral immune responses IgA immune response immune responses Killer cell morbidity morbidity and mortality mRNA mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines N-terminal N-terminal domain natural killer natural killer cell neutralization Neutralizing antibodies neutrophil phagocytosis potential differences protective immunity RBD Receptor binding domain recipient recipients reduced Region respiratory responses robust SARS-CoV-2 the vaccine the vaccines These data Vaccine Vaccines variants variants of concern Variation Viral viral variant Viral variants wake wild-type [DOI] 10.1126/scitranslmed.abm2311 PMC 바로가기 [Article Type] Article
A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate BindingSARS-CoV-2의 스파이크 수용체 결합 도메인과 친밀한 결합의 구조적 기초를 표적으로 하는 강력한 중화 나노바디Article Published on 2022-05-182022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basis binding binding affinity binding site biochemical analyses characterization competing complex coronavirus delta variant Diseases domain drug candidates engage epitope In-vitro increase nanobodies nanobody neutralization neutralization activity Neutralizing overlapping potent Potential treatment raised receptor related diseases respiratory reveal S-RBD SARS-CoV-2 SARS-CoV-2 S severe acute respiratory syndrome Coronavirus spike receptor-binding domain Spread structural basis target targeting the Spike These data Viral viral spike virus [DOI] 10.3389/fimmu.2022.820336 PMC 바로가기 [Article Type] Article