[Effect and mechanism of Mahuang Tang against influenza A/H1N1 virus in vitro]Article Published on 2018-02-012023-06-23 Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of [Category] 신종인플루엔자, [키워드] Influenza A/H1N1 virus Mahuang Tang MDCK cell TLR4 TLR7 virus load [DOI] 10.19540/j.cnki.cjcmm.20171113.010
Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse modelTLR7 작용제를 세포가 없는 백일해 백신에 추가하면 마우스 모델에서 Th1 및 Th17 반응과 보호 면역이 향상됩니다.Article Published on 2017-09-182024-08-25 Journal: Vaccine [Category] 백일해, [키워드] adjuvant pertussis protective immunity TLR7 Vaccine [DOI] 10.1016/j.vaccine.2017.08.009
Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in MiceArticle Published on 2017-09-122023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] adjuvant Influenza virus TLR4 TLR7 Toll-like receptor Vaccine [DOI] 10.1128/JVI.01050-17 PMC 바로가기
Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profilesResearch Article Published on 2017-02-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Activation association bronchitis changes CMI downregulation early immune response epithelial cell expression expression profile Genotype IBV immune immune modulatory immune response Increased Infectious Bronchitis Virus Inflammatory isolate kidney lesion local immune response lower expression mechanism Morphological Pathogenesis pathological change pathway pro-inflammatory response profile renal replicate Replication response responses TLR7 tracheal upper respiratory tract Viral load viral replication virulence virus [DOI] 10.1371/journal.pone.0172275 PMC 바로가기 [Article Type] Research Article
The link between TLR7 signaling and hepatitis B virus infectionReview Published on 2016-08-012023-06-18 Journal: Life sciences [Category] B형 간염, [키워드] Hepatitis B virus (HBV) prolonged HBV infection TLR7 [DOI] 10.1016/j.lfs.2016.06.026 [Article Type] Review
Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malariaToll-like 수용체 7의 손실은 사이토카인 생산을 변화시키고 실험적 뇌 말라리아로부터 보호합니다.Research Published on 2014-09-052024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] cerebral malaria Cytokines mouse Plasmodium berghei TLR7 Toll-like receptors [DOI] 10.1186/1475-2875-13-354 PMC 바로가기 [Article Type] Research
MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus ErythematosusMicroRNA-3148은 전신성 홍반성 루푸스와 관련된 톨 유사 수용체 7 변이체의 대립형질 발현을 조절합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3′ UTR 3′UTR activate affecting African Americans allelic Americans Antigen Asian Asians association Author Autoimmune Autoimmune disease binding binding site C allele C-allele carriers conducted contributed Control copy number correlated debilitating autoimmune disease decrease Degradation dose-dependent downregulated driven by duplication elevated Epigenetic European Evidence exhibited exhibiting expression functional G allele G-allele genomic greater HEK-293 HEK-293 cell HEK-293 cells Human identify IFN IFN-α pathway increased risk independent individual innate immune activation lack led to luciferase luciferase activity Lupus lupus erythematosus lupus-like disease mechanism microRNA microRNA-3148 microRNA–gene miR-3148 modulation mononuclear cell mononuclear cells mRNA murine model non-risk allele non-risk C allele nuclear nucleotide Odds ratio overexpression Pathways PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells polymorphism predicted promote Protein protein level provide R 2 reduction regulate Regulatory reported reporter reporter gene respond resulting risk sequence signaling pathways significantly increased single nucleotide Single nucleotide polymorphism SLE SLE patient SLE patients SNP subject susceptibility systemic systemic lupus erythematosus the strongest These data TLR7 TLR7 gene TLR7 mRNA TLR7-TLR8 region TLR7/8/9 TLRs Toll-like receptor toll-like receptor 7 Toll-like receptors transcript transcript level transcripts transfected cells type I interferon UTR variant Variation while [DOI] 10.1371/journal.pgen.1003336 PMC 바로가기 [Article Type] Research Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article
CD200 Receptor Controls Sex-Specific TLR7 Responses to Viral InfectionResearch Article Published on 2012-05-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence Activation administration anti-viral response Author blocker Cancer CD200 clearance clinical trial Control dependent on determine determined different disease disease symptom ENhance Factor female female patient females Host humans Hypothesis IFN immune immune inhibitory immune response immune system immunological impair implication IMPROVE in vitro in vivo Infection influenza A virus Influenza virus inhibit inhibitory inhibitory signal lack Ligand lung MHV mice microbial infection mouse hepatitis neutrophil observé outcome overactive pathogen pathology pathway predict Prevent provided receptor receptors Release reported response Sex Sex difference Signaling supported suppresse therapeutic targeting therapeutic use threshold TLR7 Treatment Type I IFN type I interferon viral clearance viral infection virus virus infection [DOI] 10.1371/journal.ppat.1002710 PMC 바로가기 [Article Type] Research Article