Specific CD8 + TCR Repertoire Recognizing Conserved Antigens of SARS-CoV-2 in Unexposed Population: A Prerequisite for Broad-Spectrum CD8 + T Cell ImmunityArticle Published on 2021-09-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome adaptive analyzed antibody immunity Antigen Blood broad-spectrum adaptive immunity CD8 CD8+ T cell CDR3 clone Clustering Cohort complementary conserved coronavirus coronavirus disease COVID-19 cross-reactive effort epitope Epitopes Evidence healthy healthy donor help Immunity implementation implicated IMPROVE in vitro individuals membrane memory T cell MHC-I mononuclear cell Mutation naïve neutralization nucleocapsid PBMCs peptide peptides peripheral populations proportion Protein Proteins provide recognizing recovered patient repertoire SARS-CoV-2 selected Sequencing Specific stimulated T cell T cell receptor T cells TCR TCR repertoire TCR sequencing the healthy therapy translational Vaccine variant virus [DOI] 10.3390/vaccines9101093 PMC 바로가기 [Article Type] Article
Multi-level inhibition of coronavirus replication by chemical ER stressArticle Published on 2021-09-202022-10-04 Journal: Nature Communications [Category] SARS, 치료제, [키워드] Analysis Antiviral antiviral effects autophagic flux block bronchial epithelial cells cell type chaperone complexes component coronavirus Coronavirus replication counteract CoV replication CoVs Degradation derivative downregulation drugs ER stress Evidence Factor HCoV-229E HERPUD1 Host human pathogen IMPROVE inducer infected cell Infection inhibit inhibiting mechanism MERS-CoV modulate pathway Pathways pharmacological Protein proteome Quality control Replication required SARS-CoV-2 selective specific treatment suppress suppresse Systems virology translational UBA6 unfolded protein response viability viral infection Virus-host interactions ZNF622 [DOI] 10.1038/s41467-021-25551-1 PMC 바로가기 [Article Type] Article
Development of a physiological model of human middle ear epitheliumOriginal Research Published on 2021-09-182022-10-30 Journal: The Laryngoscope [Category] COVID-19, [키워드] acute infection Antimicrobial therapy Biological models cells changed children ciliated clinical implication complex conditions Culture develop development disease Diseases epithelial epithelial cell epithelial cell type goblet immunofluorescence immunohistochemistry in vivo lack Level media membrane Microscopy mucosal otitis otitis media otorhinolaryngologic diseases physiological polymerase chain positive reflect Research respiratory mucosa Result Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 shown subtype susceptible the healthy translational transmission electron microscopy Treatment undergo Ventilated [DOI] 10.1002/lio2.661 PMC 바로가기 [Article Type] Original Research
Brain Organoids: Studying Human Brain Development and Diseases in a DishReview Article Published on 2021-09-092022-10-29 Journal: Stem Cells International [Category] COVID-19, [키워드] Brain brain organoid Cell cell type compounds development disease Dish Human limitation Neurological disorders organized Organoid suspension culture translational [DOI] 10.1155/2021/5902824 PMC 바로가기 [Article Type] Review Article
Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm스파이크 단백질의 구조적으로 제한된 영역에 매핑되는 CD8 에피토프 변성: SARS-CoV-2 변이체 폭풍으로부터의 T 세포 기반 탈출구Review Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Analysis analyzed arising B cell responses can not candidate CD8 CD8 T cell CD8 T cell epitopes CD8 T cell responses CD8 T cells CD8 T-cell Cell-mediated immunity compensated conserved COVID-19 vaccines cross-neutralization degenerate Efficacy ENhance epitope Epitopes Evolution expected HLA HLA class I HLA class I molecules immune response immune responses immunization immunodominant impairing inactivation limit maintain mapping mutate mutations Neutralizing antibodies Perspective Population Protective protective immunity Region response S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variants spike region stimulatory storm T cell T cell epitopes T cells the SARS-CoV-2 the Spike translational vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variant variants variants of concern Viral viral escape viral variant Viral variants [DOI] 10.3389/fimmu.2021.730051 PMC 바로가기 [Article Type] Review
Characterization by Quantitative Serum Proteomics of Immune-Related Prognostic Biomarkers for COVID-19 SymptomatologyCOVID-19 증상에 대한 면역 관련 예후 바이오마커의 정량적 혈청 단백질체학에 의한 특성화Immunology Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] affecting Algorithm Analysis Asymptomatic biological processe Biomarker Biomarkers caused characterization Cohort contribute contributed correlated COVID-19 COVID-19 disease COVID-19 pandemic Data analysis diagnostic disease Disease progression disease progression and severity disease symptom disease symptoms disorder disorders dysregulated ELISA Factor FIVE healthy healthy individual healthy individuals hospital discharge Hospitalized immunology increase intensive care intensive care unit molecular interaction pandemic physiological PON1 Predictive Predictive value profile prognostic prognostic biomarker Prognostic biomarkers Protein proteomic proteomics Quantitative representation SARS-CoV-2 selected SELENOP Selenoprotein P Serum protein serum proteins severe cases severity significantly Symptomatology systemic inflammation therapeutic intervention translational with COVID-19 zone [DOI] 10.3389/fimmu.2021.730710 PMC 바로가기 [Article Type] Immunology
COVID-19: protocol for observational studies utilizing near real-time electronic Australian general practice data to promote effective care and best-practice policy—a design thinking approachStudy Protocol Published on 2021-09-072022-10-31 Journal: Health Research Policy and Systems [Category] COVID-19, SARS, [키워드] approach can be used Care carried Community COVID-19 COVID-19 pandemic COVID-19 testing Design thinking Diagnosis disease effective ENhance Evidence feasibility General practice groups Health healthcare hospital identify infection control Level maintain Melbourne MONITOR New observational studies observational study Outbreaks outcomes Pandemics pathology platform professionals promote protocol quality of care Reporting researchers secure South translational Treatment valuable resource [DOI] 10.1186/s12961-021-00772-4 PMC 바로가기 [Article Type] Study Protocol
OGT Protein Interaction Network (OGT-PIN): A Curated Database of Experimentally Identified Interaction Proteins of OGTArticle Published on 2021-09-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Arabidopsis thaliana Cell cells cellular database dataset determine DNA repair Drosophila melanogaster enzyme functional Homo sapien hub protein human protein Identified Interaction its target proteins metabolism molecular network Mus network O-GlcNAc OGT OGT interactome Protein Protein–protein interaction protein–protein interactions Rattus Regulation Repository RNA significant enrichment Transcription translational [DOI] 10.3390/ijms22179620 PMC 바로가기 [Article Type] Article
Role of Heat Shock Proteins (HSP70 and HSP90) in Viral InfectionReview Published on 2021-08-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] antiviral therapy Bacteria biological significance can be used carried Cell cell differentiation chaperone complex conditions Course current death ENhance eukaryote expression facilitate Factor heat heat shock protein homeostasis Host HSP Hsp70 Hsp90 Hsps immune in some Infection Inflammatory maintain mechanism molecular basis polymerase presenting Protein Proteins responsible role SARS-CoV-2 shown stability stressors survival therapeutic potential transcriptional translational viral gene viral infection Viral protein viral replication virus [DOI] 10.3390/ijms22179366 PMC 바로가기 [Article Type] Review
Translational deep phenotyping of deaths related to the COVID-19 pandemic: protocol for a prospective observational autopsy studyObservational Study Published on 2021-08-272022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] adult pathology Algorithm approach approved Autopsy autopsy study biochemical Cardiology changes clinical trials Committee Computed tomography COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19-related death criteria database death deaths Denmark disease ENhance Ethics ethics committee extreme facilitate Factor Follow-up forensic pathology genetics help high mortality immunological immunology International journal offer organ Pandemics pathogenesis of COVID-19 pathophysiological Pathways patients peer-reviewed protection protocol provide recruitment Region Regional registry data Research tissue translational Treatment trials [DOI] 10.1136/bmjopen-2021-049083 PMC 바로가기 [Article Type] Observational Study