Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment
내열성이 높은 면역원성 SARS-CoV-2 스파이크 단편의 설계
Research Article
[키워드] ACE2
antibodies
AUC, area under the curve
clinic
clinical testing
COVID-19
CPE, cytopathic effect
Culture
DMEM, Dulbecco's Modified Dulbecco's Medium
ectodomain
elicited
Endpoint
exposure to
expressed
extreme
feature
geometric mean
geometric mean titer
glycosylation
guinea pig
HRP, horseradish peroxidase
IAEC, Institutional Animal Ethics committee
IMAC, immobilized metal affinity chromatography
immunogenic
ingredient
mammalian cell
MF59
microbial
monomeric
mRNA
Neutralizing antibodies
neutralizing antibody
NTD, N-terminal domain
PBS, phosphate buffered saline
PEI, polyethylenimine
Pichia
Protein subunit vaccines
purified
RBD
RBD protein
RBD, receptor-binding domain
RBM, receptor binding motif
Receptor-binding domain
replicative
SARS-CoV-2
SARS-CoV-2 spike
SARS-CoV-2 vaccine
SEC, size-exclusion chromatography
solution
Spike protein
subunit
Subunit vaccine
temperature
the RBD
the receptor-binding domain
thermostable
thermotolerance
Vaccine
viral spike protein
Viral vector
viral vectors
virus
[DOI] 10.1074/jbc.RA120.016284 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1074/jbc.RA120.016284 PMC 바로가기 [Article Type] Research Article