A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5)Article Published on 2014-05-232022-10-06 Journal: Vaccine [Category] 진단, [키워드] antigen-specific antibody BALB/c mice cause children Efficacy evaluate exacerbate expressing glycoprotein Histopathology Hospitalization Human immune individuals Infant Infection lung lung lesion mice morbidity and mortality parainfluenza virus Parainfluenza virus 5 platform protective immunity Protein respiratory respiratory syncytial virus responses RSV severe respiratory disease the vaccine vaccination Vaccine Vaccine development vaccine strain virus were used wild-type [DOI] 10.1016/j.vaccine.2014.03.049 PMC 바로가기 [Article Type] Article
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence AttenuationCryptococcus neoformans var.의 게놈 및 전사체 분석 grubii, 복잡한 RNA 발현 및 독성 약화로 이어지는 소진화를 밝혀냄Research Article Published on 2014-04-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition alternative polyadenylation Analysis analyzed annotation attenuation automated C. neoforman CDS chromosomal coding coding DNA sequence coding DNA sequences Comparative analysis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans death Efficiency examination expressed gene expressed genes feature fungi Gene Expression Genes Genetic genetics Genome genome sequence genomic studies genomic study human pathogen identify Immunocompromised Immunocompromised patients in vitro culturing indicate intron introns involved isolate isolates Laboratory leading manual curation meningoencephalitis microevolution microevolutionary miscRNA miscRNAs molecular motif Mutation Non-coding RNAs occur opportunistic pathogen pathogen pathogenic performed phenotypic phenotypic and genome re-sequencing analysis polyadenylation site polyadenylation sites provide Region Regulation Replication representing responses responsible resulting RNA RNA-Seq-based analysis sequence sequenced sequences Sequencing serotype Spectrum strain Stress stress responses Transcription Transcriptome untranslated regions UTRs VAR variant variety virulence yeast [DOI] 10.1371/journal.pgen.1004261 PMC 바로가기 [Article Type] Research Article
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS VirusResearch Article Published on 2012-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute respiratory syndrome antibody C57BL/6 candidate vaccine caution challenge change changes in China component control group country dosage eosinophil evaluated exhibited ferret Histopathology Human hypersensitivity immunopathology inactivated indicated Infection infiltration Influenza initiated led to Live virus lung Lung disease mice NHP occurred Occurrence pathologic PBS pulmonary responses Result S protein SARS Coronavirus SARS-CoV SARS-CoV vaccine serum antibody Serum neutralizing antibody severe Significant reduction significantly spread to Th2-type the vaccine Vaccine Vaccine development virus VLP [DOI] 10.1371/journal.pone.0035421 PMC 바로가기 [Article Type] Research Article
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article
Long-Term Persistence of Robust Antibody and Cytotoxic T Cell Responses in Recovered Patients Infected with SARS CoronavirusResearch Article Published on 2006-12-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] against SARS-CoV Analysis antibody change changes in characterized clinical recovery CTL CTL epitope cytotoxic effective found humoral immune response immunological implication individual individuals Infected Infection Intervention moderate MOST N protein onset of symptoms outcome Patient peptides peripheral lymphocyte persistence recovered recovered patient response responses restored robust SARS Coronavirus SARS-CoV SARS-CoV-specific antibody study period subject Support T cell the disease therapeutic agent Vaccine [DOI] 10.1371/journal.pone.0000024 PMC 바로가기 [Article Type] Research Article