Analysis of Covid-19 and non-Covid-19 viruses, including influenza viruses, to determine the influence of intensive preventive measures in JapanArticle Published on 2020-07-072022-11-01 Journal: Journal of Clinical Virology [Category] COVID-19, MERS, [키워드] addition analyzed Causative caused cold-like symptom collected coronavirus coronavirus 229E COVID-19 death detect determine FilmArray incidence infected patient Infection infection control Influenza Influenza virus influenza viruses Intensive Japan métapneumovirus Multiplex PCR Nasopharyngeal swab objective OC43 Other Panel Panel analysis pathogen Patient patients PCR Prevalence prevalent preventive measure preventive measures respiratory Respiratory Coronavirus respiratory viruses Result reverse transcription PCR RT-PCR RT-PCR analysis SARS-CoV-2 SARS-CoV2 Spread Symptom virus viruses [DOI] 10.1016/j.jcv.2020.104543 PMC 바로가기 [Article Type] Article
COVID-19 pandemic lockdown: An emotional health perspective of Indians on TwitterOriginal Articles Published on 2020-07-072022-10-30 Journal: The International Journal of Social Psychiatry [Category] COVID-19, MERS, [키워드] 2019-nCoV analysed Analysis approach article country COVID-19 COVID-19 pandemic e-commerce emotional Express Government Health help Human behaviour human infection India Indian people Infection instance lockdown majority measure media novel opinion mining pandemic performed Perspective platform positive R statistical software rising Spread Tweeter Twitter virus [DOI] 10.1177/0020764020940741 PMC 바로가기 [Article Type] Original Articles
Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assayArticle Published on 2020-07-072022-10-06 Journal: Journal of virological methods [Category] MERS, SARS, 진단, [키워드] 2019-nCoV acute respiratory syndrome addition assays baseline CDC China clinical samples conducted coronavirus coronavirus 2 COVID-19 Critical detect detection rate Detection sensitivity determine develop Diagnosis diagnostic Dilution disease spread DNA IMPROVE Improved Japan N1 and N2 Nasopharyngeal swab nasopharyngeal swabs Outbreaks patients polymerase chain positive positive control primer probe probes provided Quencher required respiratory Result RT-PCR RT-PCR assay SARS-CoV-2 sensitivity sequence specificity Spread tested the SARS-CoV-2 threshold USA virus were used Wuhan [DOI] 10.1016/j.jviromet.2020.113926 PMC 바로가기 [Article Type] Article
Small molecule therapeutics for COVID-19: repurposing of inhaled furosemideCell Biology Published on 2020-07-072022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] “cytokine storm” addition Anti-inflammatory anti-inflammatory activity anti-inflammatory cytokine applicability biologic caused cell line clinical trial clinical utility coronavirus COVID-19 Cytokine storm Cytokines evaluate furosemide Health host inflammatory response hypercytokinemia identify IL-1ra IL-6 IL-8 immuno-inflammatory in silico in vitro Inhaled inhibitor of IL-6 initial Innate immunity involved lethal infection LPS mechanism of action molecular docking morbidity and mortality multiple cytokine novel coronavirus SARS-CoV-2 Pathogenesis pro-inflammatory cytokine pro-inflammatory cytokines promote Safe small molecule stimulated subsequent suppresse therapeutic therapy THP-1 TNF-α Treatment viral infection virus was reduced [DOI] 10.7717/peerj.9533 PMC 바로가기 [Article Type] Cell Biology
Earliest infections predict the age distribution of seasonal influenza A casesArticle Published on 2020-07-072023-06-08 Journal: eLife [Category] 신종인플루엔자, [키워드] Human virus [DOI] 10.7554/eLife.50060 PMC 바로가기
Serological differentiation between COVID-19 and SARS infectionsCOVID-19와 SARS 감염의 혈청학적 구별Research Article Published on 2020-07-072022-08-13 Journal: Emerging Microbes & Infections [Category] MERS, SARS, 임상, [키워드] acute disease anti-N antibodies Anti-RBD antibodies antibody antibody tests asymptomatic infection rate asymptomatic infection rates best Betacoronavirus Blood capture caused choice Contact tracing Coronaviridae coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 antibody test COVID-19 antibody tests cross-reactivity diagnostic diagnostic test diagnostic tests Disease diagnosis ELISA family Coronaviridae genus genus Betacoronavirus herd immunity humans Immunity infect Infection N protein offer other coronavirus outbreak PCR PCR test PCR tests performed protective immunity Protein RBD region required SARS SARS infection SARS patient SARS-CoV SARS-CoV-2 sequence identity sera serological test Serological tests serology significant level species specificity survivor virus waned while [DOI] 10.1080/22221751.2020.1780951 PMC 바로가기 [Article Type] Research Article
Mutation Patterns of Human SARS-CoV-2 and Bat RaTG13 Coronavirus Genomes Are Strongly Biased Towards C>U Transitions, Indicating Rapid Evolution in Their HostsArticle Published on 2020-07-072022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] analyzed bat C>U mutation caused codon coronavirus coronavirus genomes CpG CpG depletion cytosine deamination Deamination evaluated Evolution exhibited Frequency genome structure genomes hosts Human human SARS-CoV-2 hydrophobic amino acid isolate Mutation mutation bias other coronaviruses pandemic pattern Rapid RaTG13 SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV2 single nucleotide variation Spread Substitution substitutions the SARS-CoV-2 transfer variant virus [DOI] 10.3390/genes11070761 PMC 바로가기 [Article Type] Article
Pulse Therapy With Corticosteroids and Intravenous Immunoglobulin in the Management of Severe Tocilizumab-Resistant COVID-19: A Report of Three Clinical CasesEmergency Medicine Published on 2020-07-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] changes clinical clinical manifestation Combination Corticosteroids COVID-19 CRS Cytokine release syndrome Efficacy and safety Evidence high-dose methylprednisolone Immunoglobulin intravenously life-threatening life-threatening coronavirus disease Methylprednisolone Patient patients persistence pulmonary CT pulse pulse therapy Randomized controlled trial report required Respiratory failure Safe SARS-CoV-2 therapy Treatment treatment regimen virus [DOI] 10.7759/cureus.9038 PMC 바로가기 [Article Type] Emergency Medicine
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaquesArticle Published on 2020-07-072022-11-01 Journal: Cell Research [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus candidate vaccine cause characterized demonstrated edema evaluate Genome-wide association studies Infection infiltration interstitial pneumonia lung lung; lymphocyte Mild monocyte mortality rate neutralizing antibody non-human primate model Novel coronavirus observation occurred oropharyngeal swab oropharyngeal swabs outbreak platform Pneumonia post infection Primary infection PROTECT provide public health reflected Replication respiratory tract respiratory tract tissues rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RNA severe cases susceptible viral infection Viral RNA virus Whole genome amplification World Health Organization [DOI] 10.1038/s41422-020-0364-z PMC 바로가기 [Article Type] Article
Exploring the acceptability of controlled human infection with SARSCoV2—a public consultationCorrespondence Published on 2020-07-072022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] accelerate benefit complex conducted Controlled human infection model COVID-19 death dissemination domain effective Efficacy enrolment Final human infection individual individuals Infection information positive Public consultation question raise Rapid required risk SARSCoV2 significant level social isolation supportive care Treatment Vaccine Vaccines virus Volunteer [DOI] 10.1186/s12916-020-01670-2 PMC 바로가기 [Article Type] Correspondence