25-Hydroxycholesterol in health and diseasesReview Published on 2023-12-162024-09-05 Journal: Journal of Lipid Research [Category] update2024, [키워드] 25-Hydroxycholesterol 7α,25-dihydroxycholesterol ABCA1 cholesterol LXR Oxysterols reverse cholesterol transfer [DOI] 10.1016/j.jlr.2023.100486 PMC 바로가기 [Article Type] Review
Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Micearticle Published on 2023-08-142024-09-05 Journal: American Journal of Respiratory Cell and Molecular Biology [Category] update2024, [키워드] 25-Hydroxycholesterol cholesterol-25-hydroxylase EBI2 Pneumonia SARS-CoV-2 [DOI] 10.1165/rcmb.2023-0007OC PMC 바로가기 [Article Type] article
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review
25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human CoronavirusesArticle Published on 2021-11-012022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] 25-Hydroxycholesterol activity Anti-SARS-CoV-2 Activity antiviral activity caused CH25H cholesterol Combination concern CoV COVID-19 pandemic effective feasible fusion inhibitor global public health HCoV-229E HCoV-OC43 Human human coronavirus human CoVs IMPROVE Infection inhibitor lipopeptide mice Modification Newborn Other peptide peptide-based potent PROTECT reported SARS-CoV-2 SARS-COV-2 infection synergistic variants of concern VOCs [DOI] 10.3390/ijms222111869 PMC 바로가기 [Article Type] Article
Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During DevelopmentPhysiology Published on 2021-10-082022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] 25-Hydroxycholesterol acting Cell cellular change cholesterol cholesterol dependent cytolysin cholesterol homeostasis development hedgehog signalling pathway HMG-CoA reductase Hypothesis INSIG mechanism microbial paracrine pathogen pathway plasma membrane provide SARS-CoV-2 SREBP pathway [DOI] 10.3389/fphys.2021.723224 PMC 바로가기 [Article Type] Physiology
Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)Article Published on 2020-06-102022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 25-Hydroxycholesterol acute respiratory syndrome addition AM580 animal model anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antigen expression Antiviral antiviral activity antiviral agent Antiviral agents caused Chloroquine clinical trials coronavirus COVID-19 evaluated exhibited expression in viral interferon interferons investigated Lipogenesis option pandemic Plaque reduction assay plaque reduction assays Potential Remdesivir Replication SARS-CoV-2 targeting the SARS-CoV-2 Treatment VeroE6 cell Viral antigen viral load reduction viruses [DOI] 10.3390/v12060628 PMC 바로가기 [Article Type] Article