Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
Clinical update on COVID-19 for the emergency clinician: Airway and resuscitationReview article Published on 2022-08-012022-10-05 Journal: The American journal of emergency medicine [Category] 임상, [키워드] airway management approach ARDS ARDS patient blocking agent clinical clinically clinician Clinicians Coronavirus-2019 COVID-19 disease dose ECMO extracorporeal membrane oxygenation HFNC IMPROVE indicated Inhaled initial initiated intravenous fluids intubation intubation rate Limited management nasal nippv Non-invasive objective Oxygenation pandemic Patient patient population patients patients with COVID-19 physician Plateau pressure positive pressure ventilation predicted progressed prone provide recruitment SARS-CoV-2 Septic shock severe acute respiratory syndrome coronavirus 2 shown steroid Strategy Support Vasopressor Volume with COVID-19 [DOI] 10.1016/j.ajem.2022.05.011 [Article Type] Review article
Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trialClinical Trial Published on 2022-06-282022-10-05 Journal: Stem Cell Research & Therapy [Category] 임상, [키워드] acute respiratory distress syndrome addition adverse effect approach ARDS ARDS patient ARDS patients Cell change clinical clinical trial control group correlated COVID-19 pandemic COVID-19 patient CRP level CT scan Cytokine storm demonstrated disease distress Features follow-up period functions IFN-g IL-10 IL-17 IL-1B IL-6 Inflammatory cytokines injection Intervention intervention group intravenous intravenous infusion Mesenchymal stromal cells Mild-to-moderate MSC MSCs Open-label Patient Registered registry required respiratory Safe Safety Sample size serum CRP serum cytokine serum cytokine level significant decrease significant increase single-center SPO standard care stromal cell study period syndrome therapy TNF-α UC-MSC UC-MSCs umbilical were assessed [DOI] 10.1186/s13287-022-02920-1 PMC 바로가기 [Article Type] Clinical Trial
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation Research Published on 2022-05-272022-10-05 Journal: Nature Immunology [Category] 유전자 메커니즘, 진단, [키워드] acute lung injury acute respiratory distress ARDS ARDS patient Bone marrow circulating monocytes Host Hypoxemia hypoxemic hypoxia hypoxic immune immune response immune responses Inflammation Injury Intervention lung Lung injury mice monocyte-derived macrophage monocytopenia mouse model offer persistence phenotype promote reduced rescued resulting shown Signaling syndrome systemic inflammation therapeutic strategy tissue type I interferon Ventilation [DOI] 10.1038/s41590-022-01216-z [Article Type] Research
COVID-19 infection: an overview on cytokine storm and related interventionsCOVID-19 감염: 사이토카인 폭풍 및 관련 중재에 대한 개요Review Published on 2022-05-262022-09-12 Journal: Virology Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory distress acute respiratory syndrome Affect ARDS ARDS patient cause caused conditions Coronavirus disease 2019 Coronavirus-2 COVID-19 Critically ill patient CRS Cytokine storm death defined Efficacy elevated Health IL-1 IL-17 IL1 IL6 impairment IMPROVE Infection Inflammatory response interleukin-6 Interleukins Intervention lung damage Patient patients with COVID-19 Pneumonia pro-inflammatory pro-inflammatory cytokines respiratory epithelium respiratory tract SARS-CoV-2 specific inhibitor specific treatment survival rate syndrome systemically TNF-α triggered tumor necrosis factor-alpha virus [DOI] 10.1186/s12985-022-01814-1 PMC 바로가기 [Article Type] Review
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate to severe ARDS in a randomized, placebo-controlled, double-blind trial: preliminary evaluation of safety and feasibility in light of the COVID-19 pandemicRandomized Controlled Trial Published on 2022-04-042022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] activity Alter ARDS ARDS patient Ascending baseline causes Clinical characteristics clinical study clinical trial conducted COVID-19 COVID-19 ARDS patient COVID-19 pandemic COVID-19 patient doses double-blind DSMB edema Efficacy enrolled Enrollment Evidence exceptional feasibility groups indication interim analysis investigator less mandatory Multiple multiple ascending dose noradrenaline not differ observation period outcome Oxygenation pandemic parameter Patient patients with moderate permeability phase IIB placebo-controlled pulmonary Pulmonary edema pulmonary permeability Randomized required risk Safety Safety Monitoring Board SARS-CoV-2 Sepsis severe ARDS sick Solnatide Study design survival rate treat Trial Ventilation [DOI] 10.1186/s13063-022-06182-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Focus on renal blood flow in mechanically ventilated patients with SARS-CoV-2: a prospective pilot studyObservational Study Published on 2022-02-012022-10-05 Journal: Journal of clinical monitoring and computing [Category] COVID19(2023년), SARS, 임상, [키워드] Acute kidney injury acute respiratory syndrome AKI ARDS ARDS patient blood flow coronavirus Coronavirus-2 correlation COVID-19 Doppler driving etiologies focus Hypothesis impairment kidney linear lowest Mechanical mechanical ventilation mechanically ventilated patient Patient patients with ARDS PEEP performed pilot study Prospective renal Renal resistivity index SARS-CoV-2 SARS-CoV-2 patient susceptible Ultrasound venous ventilated patient Ventilation Volume [DOI] 10.1007/s10877-020-00633-5 PMC 바로가기 [Article Type] Observational Study
Respiratory and peripheral muscular ultrasound characteristics in ICU COVID 19 ARDS patientsICU COVID 19 ARDS 환자의 호흡기 및 말초 근육 초음파 특성Observational Study Published on 2022-02-012022-09-11 Journal: Journal of critical care [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Admission affected ARDS ARDS patient benefit change Characteristics clinically coronavirus disease Coronavirus disease 2019 correlation COVID 19 COVID19 cross-sectional area cumulative dead patients develop Diaphragm diaphragmatic echogenicity Fluid balance Grayscale Grayscale analysis ICU intubated patient material mechanical ventilation muscle muscles muscular Muscular ultrasound. observational study parasternal Patient performed prospective observational study Protein reduce respiratory severe cases significantly significantly lower survived therapy thickness Ultrasound Urine [DOI] 10.1016/j.jcrc.2021.09.007 PMC 바로가기 [Article Type] Observational Study
Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol급성 호흡 곤란 증후군에서 환기를 평가하기 위한 의사 결정 지원 시스템(DeVENT 연구) - 시험 프로토콜Study Protocol Published on 2022-01-172022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome allocation approach ARDS ARDS patient ARDS patients clinical decision clinical trial complex concealed contribute Course COVID-19 COVID-19 pandemic Critical care Decision support decision support system decision support systems decrease decreases determine determined by driving End-Expiratory Pressure evaluate facilitate help IMPROVE improvement International Local lung Lung injury management mathematical Mathematical models mechanical ventilation Mechanical ventilation; Acute respiratory distress syndrome mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mitigation morbidity morbidity and mortality Mortality occur open outcome pandemic Pandemics Patient patients PEEP personalised physiological state point-of-care Positive end-expiratory pressure Pragmatic pressure protective effect Protective effects protocol randomised reduction in respiratory distress Respiratory distress syndrome routine care severity supplementary material Support Support System syndrome variety ventilated patient ventilated patients Ventilation ventilator Ventilator-induced lung injury ventilatory strategy [DOI] 10.1186/s13063-021-05967-2 PMC 바로가기 [Article Type] Study Protocol