ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?Article Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accumulated aging atopic atopic dermatitis bat bat coronaviruses cause Cell China conditions coronavirus COVID-19 Diabetes Mellitus disease Diseases enzyme epidemiological data Europe Exacerbation help highest homology Host Human humans hypertension infect Inflammation Inflammatory inflammatory condition mechanism membrane fusion Middle East occurred poor prognosis promote psoriasis pulmonary disease receptor ACE2 SARS-CoV-2 skin skin. TMPRSS viral infection virus [DOI] 10.3390/ijms232012260 PMC 바로가기
Decrease in COVID-19 adverse outcomes in adults during the Delta and Omicron SARS-CoV-2 waves, after vaccination in MexicoArticle Published on 2022-09-132022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] accumulated adverse outcome affected age Analysis analyzed caused children circulation country COVID-19 COVID-19 epidemic COVID-19 epidemic in Mexico COVID-19 hospitalization COVID-19 in children COVID-19 in pregnancy COVID-19 vaccination dataset death decrease Delta driven by dropped effective Effectiveness excess mortality. fatality health authorities hospitalizations individual Infant limit Mortality National omicron Omicron sub-lineages outbreak pediatric pregnant reduced retrospective cohort SARS-CoV-2 SARS-CoV-2 Delta VOC SARS-CoV-2 vaccine severe COVID-19 vaccination Vaccination strategy Vaccine Vaccines variants [DOI] 10.3389/fpubh.2022.1010256 PMC 바로가기
PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during fluArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] accumulated CD4 Cell characterized co-stimulatory receptor COVID Critical Express expressed flu fluorescent FOXP3 GFP heterogenous human population iCoS IL-10 Immune homeostasis immunopathology in vivo Infection infections Influenza influenza infection influenza infections labeling lung tissue memory T cells molecular feature PD-1 proinflammatory promote Regulatory Regulatory T cell repeated reporter respiratory infectious disease response reveal secondary infections shown Signaling signaling pathway suppress T cell T cell response T cells tissue tissue repair tissue resident T cells. transcription factor Treg Treg cell Treg cells Tuberculosis [DOI] 10.3389/fimmu.2022.984476 PMC 바로가기
Most frequently harboured missense variants of hACE2 across different populations exhibit varying patterns of binding interaction with spike glycoproteins of emerging SARS-CoV-2 of different lineagesArticle Published on 2022-09-012022-11-16 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] accumulated African amino acid substitution analysis AY.1 B.1.617.2 B.1.621 binding binding interaction China Combination Complexes COVID-19 Delta docking domain Effect exhibited Factors Genetic hACE2 hACE2. Host human Angiotensin-converting enzyme Interaction investigated Latin Lineage missense variant Missense variants MM/GBSA molecular docking molecular docking analysis molecular dynamics Molecular dynamics simulation MOST Mutation mutations non-Finnish European omicron Population populations predict prevalent protein stability rate of infection RBD Receptor binding risk SARS-CoV-2 SARS-CoV-2 RBD South Asian spike glycoprotein suffered the SARS-CoV-2 Transmissibility variant variants variants of concern viral variant virus was performed Wuhan [DOI] 10.1016/j.compbiomed.2022.105903 PMC 바로가기
Multi-label classification for biomedical literature: an overview of the BioCreative VII LitCovid Track for COVID-19 literature topic annotationsArticle Published on 2022-08-312022-11-15 Journal: Database: The Journal of Biological Databases and [Category] 진단, [키워드] accumulated annotation article automated community effort coronavirus disease COVID COVID-19 database dataset downstream eight growth help highest Interpretation manual curation MOST organized pandemic participated reported significantly submission Topic track Vaccine [DOI] 10.1093/database/baac069 PMC 바로가기
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다Article Published on 2022-08-232022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단, [키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics metabolomics. mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19 [DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article
Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity상승된 Myl9는 SARS-CoV-2 유발 폐삼출성 혈관염에서 Myl9 함유 미세혈전을 반영하고 COVID-19 중증도를 예측합니다Article Published on 2022-08-162022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accompanied accumulated activation of platelets acute respiratory syndrome analysis Autopsy Clinical severity coronavirus coronavirus disease correlated COVID-19 COVID-19 patient COVID-19 severity exudative vasculitis fatal disease histological immune dysregulation immunothrombosis lung marker Microscopy microthrombi monocyte mononuclear cell Mortality nonconventional monocytes Pathogenesis pathology Peripheral blood plasma plasma Myl9. predict provide reflect SARS-CoV-2 severity Single-cell RNA sequencing the disease treatment for COVID-19 Vascular Vasculitis vessels X-ray spectroscopy [DOI] 10.1073/pnas.2203437119 PMC 바로가기 [Article Type] Article
Evaluation of SARS-CoV-2 transmission in COVID-19 isolation wards: On-site sampling and numerical analysisCOVID-19 격리 병동에서 SARS-CoV-2 전파 평가: 현장 샘플링 및 수치 분석Article Published on 2022-08-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulated aerosol aerosol transmission Aerosols Analysis calculated CFD collected Computational fluid dynamics Computational Fluid Dynamics (CFD) correlated COVID-19 deposition dispersion effective evaluated Hong Kong indoor environment Intervention investigated Isolation measure Numerical Analysis Particle Particles positive positive rate Prince reducing RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 transmission SARS-CoV-2. Spread Testing the SARS-CoV-2 Transmission transmission of SARS-CoV-2 Ventilation virus [DOI] 10.1016/j.jhazmat.2022.129152 PMC 바로가기 [Article Type] Article
Determining SARS-CoV-2 non-infectivity state-A brief overviewArticle Published on 2022-08-122022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] accumulated addition addressed applied claimed clinical experience Combination Consequences contagiousness coronavirus 2 COVID-19 COVID-19 pandemic determine Determining detrimental Iceland Immunity infected individual non-infectious non-infectious state pandemic patients with COVID-19 physician question reached respiratory SARS-CoV-2 Transmission transmission of SARS-CoV-2 transmitted variants viral testing. virulent [DOI] 10.3389/fpubh.2022.934242 PMC 바로가기