Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)Research article Published on 2022-08-262022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Administered Adults aerobic age asymptomatic infection base Blood BMI cardiovascular complications cholesterol cohort study Concentration control group COVID-19 COVID-19 group criteria defined Diagnosis diagnostic dyslipidaemia enrolled fatigue Fatigue scale female finding Follow-up force funding Health healthy higher risk individual Intensive IQR Laboratory Laboratory parameters LDL longitudinal cohort study male management median men metabolic disorder negative RT-PCR neurological no symptoms non-hospitalised organ systems outcomes participant Participants persistent physical polymorphism positive positive PCR test presenting Prevalence Psychological public health quantified questionnaire Registered renal reported reproductive RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serologically serologically positive significant difference study groups Switzerland Symptom the median threshold were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00449-2 [Article Type] Research article
Efficacy of an asynchronous telerehabilitation program in post-COVID-19 patients: A protocol for a pilot randomized controlled trial코로나19 이후 환자에 대한 비동기식 원격 재활 프로그램의 효능: 파일럿 무작위 대조 시험을 위한 프로토콜Article Published on 2022-07-192022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] aerobic appear both groups clinical Combination consequence COVID-19 decrease determine discharged Efficacy evaluated Factor fatigue Follow-up functional Functional status greater hospital Identifier in both group Intervention outcome participant Patient physical platform post-COVID-19 patient Post-COVID-19 patients preventive intervention preventive interventions Primary outcome protocol Psychological Randomized controlled trial Randomly Registered rehabilitation Sample size scale severe fatigue severity strength Symptom therapeutic Trial variable [DOI] 10.1371/journal.pone.0270766 PMC 바로가기 [Article Type] Article
Aerobic capacity of professional soccer players before and after COVID-19 infectionObservational Study Published on 2022-07-132022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] addition aerobic age COVID-19 COVID-19 infection demonstrated full recovery highlight improvement indicated Infection medium participated respiratory compensation significantly higher significantly lower statistical analysis threshold ventilatory [DOI] 10.1038/s41598-022-16031-7 PMC 바로가기 [Article Type] Observational Study
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Thorax [Category] 임상, [키워드] 1:1 95% CI aerobic Block randomisation China COVID-19 COVID-19 patient demonstrated Dyspnoea Effect Exercise capacity Follow-up form greater hospital hospitalised increase Jiangsu lower limb muscle Lung function maximum voluntary ventilation outcome physical Pulmonary function pulmonary rehabilitation Quality of life randomised randomised controlled trial rehabilitation secondary survivor Thoracic treatment effect Trial walking distance were assessed [DOI] 10.1136/thoraxjnl-2021-217382 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesisSARS-CoV-2는 활성화된 뉴클레오티드 합성에 대한 염증 반응의 회피를 결합합니다Article Published on 2022-06-282022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus aerobic aerobic glycolysis Antiviral antivirals aspartate CAD cellular coronavirus de novo deamidation deplete dihydroorotase effective enzyme evidenced Genetic changes Glycolysis highlighting host immunity Inflammatory Inflammatory response inhibitor metabolism metabolite metabolites NF-κB NF-κB activation Nsp9 nucleotide offer pressure promote provide pyrimidine RELA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent targeting up-regulate Vaccinations variant Waves while [DOI] 10.1073/pnas.2122897119 PMC 바로가기 [Article Type] Article
Clinical (BMI and MRI) and Biochemical (Adiponectin, Leptin, TNF-α, and IL-6) Effects of High-Intensity Aerobic Training with High-Protein Diet in Children with Obesity Following COVID-19 InfectionRandomized Controlled Trial Published on 2022-06-112022-10-05 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] adipocytokines adiponectin aerobic aerobic training attribute baseline biochemical block randomization BMI children children with obesity clinical COVID-19 COVID-19 infection CsA diet Effect eight eligible participant Follow-up group high protein diet high protein diet. homogenous IL-6 Intervention Leptin measure MRI muscle mass obesity physical activity Randomized the study group TNF-α training Trial two groups variable were measured [DOI] 10.3390/ijerph19127194 PMC 바로가기 [Article Type] Randomized Controlled Trial
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
A multisystem, cardio-renal investigation of post-COVID-19 illnessArticle Published on 2022-06-012022-10-04 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] abnormality Activation aerobic age Anxiety Biomarkers Blood Chest computed tomography Clinical outcome Control COVID-19 Depression died Electrocardiography Electronic health records Evidence Exercise capacity female Follow-up Health healthcare service Hemostasis Hospitalization Hospitalized impairment In-hospital include likelihood magnetic resonance imaging myocarditis outcome measure oxygen utilization pathophysiology pathway Patient patients people with COVID-19 predicted prospective cohort study Quality of life reflected secondary care Seven syndrome total score trajectory unlikely were assessed with COVID-19 [DOI] 10.1038/s41591-022-01837-9 PMC 바로가기 [Article Type] Article
Effects of Two Short-Term Aerobic Exercises on Cognitive Function in Healthy Older Adults during COVID-19 Confinement in Japan: A Pilot Randomized Controlled TrialRandomized Controlled Trial Published on 2022-05-192022-10-05 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] aerobic Aerobic exercise Affect assigned body composition cognitive Cognitive function conducted control group Controlled coronavirus disease COVID-19 dancing Dementia Effect effective intervention executive exercise Exercise intervention function gait speed greater group healthy IMPROVE improvement Intervention muscle mass neurological function Nordic walking Older Older adults pandemic participant physical Physical function Randomized controlled trial Randomly significantly single-blind social isolation [DOI] 10.3390/ijerph19106202 PMC 바로가기 [Article Type] Randomized Controlled Trial