SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesisSARS-CoV-2는 활성화된 뉴클레오티드 합성에 대한 염증 반응의 회피를 결합합니다Article Published on 2022-06-282022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activate activated acute respiratory syndrome acute respiratory syndrome coronavirus aerobic aerobic glycolysis Antiviral antivirals aspartate CAD cellular coronavirus de novo deamidation deplete dihydroorotase effective enzyme evidenced Genetic changes Glycolysis highlighting host immunity Inflammatory Inflammatory response inhibitor metabolism metabolism. metabolite metabolites NF-κB NF-κB activation Nsp9 nucleotide offer pressure promote provide pyrimidine RELA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subsequent targeting up-regulate Vaccinations variant Waves while [DOI] 10.1073/pnas.2122897119 PMC 바로가기 [Article Type] Article
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
Clinical efficacy of eucaloric ketogenic nutrition in the COVID-19 cytokine storm: A retrospective analysis of mortality and intensive care unit admissionResearch article Published on 2021-09-012022-10-05 Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] SARS, 임상, [키워드] Admission adverse event aerobic glycolysis Analysis clinical Clinical management Concentration confounding effect COVID-19 cytokine Cytokine storm syndrome Effect Efficacy feasibility hospitalized patient hyperglycemia Hypothesis IL-6 inflammatory parameters intensive care interleukin-6 ketogenic Ketogenic diet maintain Mortality non-invasive ventilation null hypothesis Patient patients with COVID-19 positive Preliminary data randomized trial reduce mortality Retrospective analysis Safe SARS-CoV-2 Secondary objective selected statistically significant difference survival therapeutic variables Warburg effect [DOI] 10.1016/j.nut.2021.111236 [Article Type] Research article
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumoniaCOVID-19 폐렴 환자에서 변경된 생체 에너지 및 단핵구의 미토콘드리아 기능 장애Report Published on 2020-11-052022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] aerobic aerobic glycolysis Affect Altered analyzed basal bioenergetics CCL2 cells chemokines classical monocytes COVID‐19 COVID‐19 CXCL10 Cytokines diminished expression Extracellular Glycolysis GM‐CSF high plasma levels IFN‐γ immature immunology Immunopathogenesis in vitro increased expression Inflammation Inflammatory cytokine Inflammatory cytokines inhibitors inhibitory inhibitory checkpoints Innate immunity investigation membrane membrane potential Microbiology, Virology & Host Pathogen Interaction Mitochondria mitochondrial mitochondrial dysfunction monocyte monocyte subsets Monocytes osteopontin oxidative burst OXPHOS Patient PD‐1 Peripheral blood peripheral blood monocytes plasma Pneumonia producing redistribution reduced respiratory capacity SARS‐CoV‐2 SARS‐CoV‐2 infection significantly subset these cell These cells TNF ultrastructure [DOI] 10.15252/emmm.202013001 PMC 바로가기 [Article Type] Report
Induction of ketosis as a potential therapeutic option to limit hyperglycemia and prevent cytokine storm in COVID-19Article Published on 2020-08-102023-06-16 Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] MERS, SARS, [키워드] aerobic glycolysis Alveolar cell type II COVID-19 Cytokine storm syndrome diabetes Disseminated intravascular coagulation hyperglycemia Interferon type I Ketogenic diet Macrophage obesity Warburg effect [DOI] 10.1016/j.nut.2020.110967 PMC 바로가기