Efficacy and safety of a proposed omalizumab biosimilar compared to the reference product in the management of uncontrolled moderate-to-severe allergic asthma: a multicenter, phase III, randomized, double-blind, equivalency clinical trialImmunology Clinical Trial Published on 2024-07-292024-09-05 Journal: Frontiers in immunology [Category] update2024, [키워드] allergic Asthma Biosimilar IgE omalizumab [DOI] 10.3389/fimmu.2024.1425906 PMC 바로가기 [Article Type] Immunology Clinical Trial
COMPARATIVE EFFECTIVENESS OF OMALIZUMAB, MEPOLIZUMAB, AND DUPILUMAB IN ASTHMA: A TARGET TRIAL EMULATIONArticle Published on 2023-02-072024-09-05 Journal: The Journal of Allergy and Clinical Immunology [Category] update2024, [키워드] allergic Asthma comparative effectiveness Dupilumab Eosinophilic mepolizumab monoclonal antibodies omalizumab Target trial emulation [DOI] 10.1016/j.jaci.2023.01.020 PMC 바로가기 [Article Type] Article
Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID-19 vaccineArticle Published on 2022-10-012022-11-15 Journal: Internal medicine journal [Category] 진단, [키워드] allergic anaphylaxis BNT162b2 mRNA Community COVID-19 COVID-19 vaccine doses eight Evidence first dose glycol hospital hypersensitivity hypersensitivity reaction Mild molecular weight New offered Patient Pfizer reaction receive receiving Record second dose thought Vaccine Vaccines [DOI] 10.1111/imj.15821 PMC 바로가기
Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 VaccineArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome allergic allergic reaction anaphylaxis antibody antigenic target Control controls coronavirus coronavirus 2 coronavirus disease COVID-19 exhibiting full-length functional humoral Humoral immunity hypersensitivity IgG1 Immunoglobulin individual messenger Messenger RNA Moderna mounted mRNA mRNA COVID-19 vaccine occur Patient Pfizer produced profile reaction receptor recipients reduction in respiratory RNA SARS-CoV-2 significantly lower Symptom systems serology vaccination Vaccine [DOI] 10.1093/infdis/jiac107 PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)Article Published on 2022-09-012022-10-04 Journal: Thorax [Category] SARS, 임상, [키워드] 1.26 95% CI age allergic allergic lung disease Asian association Asthma asthma epidemiology atopic BMI body mass index Care clinical epidemiology. COVID-19 disease Epidemiology Factor Follow-up include Increased independent information logistic regression model lung Male sex Medical conditions obesity Older age participant population-based cohort potential risk questionnaire raised recorded registry SARS-CoV-2 severe COVID-19 Sex susceptibility [DOI] 10.1136/thoraxjnl-2021-217487 PMC 바로가기 [Article Type] Article
Convalescent plasma therapy for patients with severe COVID-19: A case series study중증 COVID-19 환자를 위한 회복기 혈장 요법: 사례 시리즈 연구Case Reports Published on 2022-08-052022-09-11 Journal: Medicine [Category] SARS, 치료제, [키워드] Administered allergic allergic reaction alleviation alleviation of symptoms analyzed antiviral drug antiviral drugs arterial oxygen saturation bilateral lungs C-reactive protein case sery CD3+ CD4 CD8+ cerebral infarction Chest computed tomography Clinical data clinically collected Computed tomography convalescent plasma coronavirus disease Coronavirus disease 2019 cough COVID-19 CP infusion diabetes dysfunction early treatment effective Efficacy and safety elevated exhibited female Fever hospital hypertension IMPROVE Infarction interleukin interleukin-6 investigated lack lesion lesions lymphocyte Lymphocytes male Mild multiple-organ oxygen oxygen saturation Patient patients plasma postoperative respiratory infectious disease Safe severe adverse reaction severe adverse reactions severe COVID-19 severe disease Shortness of breath subset Supportive treatments Symptom T lymphocyte T lymphocytes the patient therapeutic therapy Thyroid Thyroid adenoma treated Treatment underlying disease [DOI] 10.1097/MD.0000000000029912 PMC 바로가기 [Article Type] Case Reports
The roles of extracellular vesicles in the immune system Reviews Published on 2022-08-042022-10-05 Journal: Nature reviews. Immunology [Category] 바이오마커, 유전자 메커니즘, 임상, 치료제, [키워드] Activation adaptive allergic Antigen presentation Autoimmune B cell Biomarker clinical trial criteria EVs Extracellular extracellular vesicle greater highlight immune responses immune system Immunity Immunotherapy Inflammation Research review T cells therapeutic therapeutic potential vaccination Vesicle [DOI] 10.1038/s41577-022-00763-8 [Article Type] Reviews
Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID-19비스테로이드성 소염제 및 기타 에이코사노이드 경로 조절제가 항바이러스 및 알레르기 반응에 미치는 영향: COVID-19 시대의 에이코사노이드 합의 보고서에 대한 EAACI 태스크포스Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료제, [키워드] allergic allergic diseases allergic inflammation allergy analgesic effect antagonist Anti-inflammatory anti-inflammatory drug Antipyretic Antiviral applied Asthma Biologicals biologicals. cannabinoids chronic inflammatory disease Consensus COVID-19 COVID-19 treatment Effect eicosanoid General population Horizon identify Inflammation Inflammatory diseases Interaction knowledge leukotriene leukotriene receptor antagonist leukotriene receptor antagonists LTRA mechanism mechanism of action medication medications NERD non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs NSAID NSAIDS pandemic of COVID-19 pathway Pathways predict prostaglandin prostaglandin D2 Research Respiratory disease respiratory infections response SARS-CoV-2 selectivity Symptom therapy Treatment unmet need viral infection viral infections [DOI] 10.1111/all.15258 PMC 바로가기 [Article Type] Article
Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 PneumoniaClinical Trial Published on 2022-08-012022-10-05 Journal: Stem cell reviews and reports [Category] COVID19(2023년), SARS, 임상, [키워드] allergic allergic reaction Chinese clinical clinical study collected CORD COVID-19 COVID-19 pneumonia demonstrated duration of hospitalization effective Efficacy evaluated Exosome Exosomes Immunity induce Lung injury Mesenchymal stem cells mild case MSC MSCs nebulization outcome Patient patients with COVID-19 Pneumonia promote pulmonary lesion purified reduce reducing registry Safe SARS-CoV-2 scientist secreted Seven STEM stem cell suggested therapeutic strategy therapy treated Treatment Trial was performed [DOI] 10.1007/s12015-022-10398-w PMC 바로가기 [Article Type] Clinical Trial